C-C motif chemokine receptor 2 and phosphodiesterase type 5 inhibition in immune subphenotypes: a step toward personalized treatment for pulmonary arterial hypertension? [0.03%]
趋化因子C-C动机受体2和磷酸二酯酶5抑制在免疫亚表型中的作用：朝向肺动脉高压的个体化治疗？
Christian J Goossen,Patrick J Pagano
Christian J Goossen
Platelet-leukocyte aggregates in cardiovascular disease: prognostic significance and therapeutic potential [0.03%]
血小板-白细胞聚集在心血管疾病中的预后意义和治疗潜力
Jiaying Han,Conor J Bloxham,Kilian Kirmes et al.
Jiaying Han et al.
Initially recognised for their role in vascular haemostasis, platelets are now understood to be critical regulators of inflammation and immune responses through complex interactions with immune cells. Key to this role is the formation of pl...
Xiaopeng Wang,Haoxun Yang,Yueyang Cheng et al.
Xiaopeng Wang et al.
Aims: The interplay between the heart and brain has been a subject of interest for centuries, as dysfunction in this interaction is implicated in various cardiovascular diseases and neurological disorders. Despite this ad...
Platelets and inflammation - insights from platelet non-coding RNA content and release in the Bruneck Study and the PACMAN-AMI trial [0.03%]
血小板与炎症——来自Bruneck研究和PACMAN-AMI试验的血小板非编码RNA含量及释放的见解
Clemens Gutmann,Temo Barwari,Christian Schulte et al.
Clemens Gutmann et al.
Aims: Platelets contain non-coding RNAs (ncRNAs), and their measurement may complement platelet aggregometry. Methods and results: In t...
Single-cell epigenomic and transcriptomic analysis unveils the pivotal role of GATA5/ISL1+ fibroblasts in cardiac repair post-myocardial infarction [0.03%]
单细胞表观基因组和转录组分析揭示GATA5/ISL1+成纤维细胞在心梗后心脏修复中的关键作用
Shuchen Zhang,Boyang Xiang,Yiheng Zhao et al.
Shuchen Zhang et al.
Aims: A comprehensive understanding of the genome-wide regulatory landscape of the cardiac tissues post-myocardial infarction (MI) is still lacking. We therefore integrated single-cell RNA sequencing (scRNA-seq) and singl...
Ceramides in cardiovascular disease - emerging role as independent risk predictors and novel therapeutic targets [0.03%]
心血管疾病中的鞘氨醇脂肪酸酯-作为独立的危险因素和新颖的治疗靶点的作用不容忽视
Roland Klingenberg,Andreas Leiherer,Dobromir Dobrev et al.
Roland Klingenberg et al.
Ceramides are bioactive lipid mediators involved in apoptosis, inflammation, and fibrosis. This narrative review provides a concise overview of the emerging role of ceramides in cardiovascular disease with emphasis on atherosclerotic vascul...
A rare gain of function variant of hepatic lipase attenuates hypercholesterolemia and atherosclerosis in mice via an LDL receptor-independent mechanism [0.03%]
一种罕见的肝脂酶功能获得性变异体通过LDL受体非依赖机制削弱小鼠高胆固醇血症和动脉粥样硬化
Thibaud Sotin,Xiaoke Ge,Milena Schönke et al.
Thibaud Sotin et al.
Aims: LIPC encodes hepatic lipase (HL), a liver-bound protein with both phospholipase and triglyceride lipase activity, and involved in the catabolism of circulating lipoproteins. We recently identified the gain-of-functi...
Jennifer J Rayner,Ines Abdesselam,Jiliu Pan et al.
Jennifer J Rayner et al.
Obesity is one of the biggest risks to public health in both developed and developing countries, and yet incidence continues to skyrocket. Being the main risk factor for a large number of life-limiting conditions, obesity has the potential ...
Adverse cardiac events associated with antibody drug conjugates in cancer patients: a retrospective analysis on the FAERS database and randomized controlled trials [0.03%]
基于FAERS数据库和随机对照试验的癌症患者心脏不良事件与抗体药物偶联物的相关性研究
Shaowei Zhuang,Bitao Wang,Enmin Wu et al.
Shaowei Zhuang et al.
Aims: Antibody Drug Conjugates(ADCs) are approved for use in cancers. Cardiovascular adverse reaction is a fatal adverse reactions associated with ADCs. The incidence of adverse cardiac events about ADCs have not been ful...