Intercellular transport of miR-146a from macrophages to vascular smooth muscle cells: a novel mechanism and therapeutic target for atherosclerosis [0.03%]
巨噬细胞向血管平滑肌细胞间传递miR-146a：动脉粥样硬化的一种新机制和治疗靶点
Phoebe Philpott,Nicholas Verity,Andrea Caporali
Phoebe Philpott
Proteins targeting ischaemic-reperfusion injury and repair after myocardial infarction: a systematic literature review [0.03%]
心肌梗死后针对缺血-再灌注损伤和修复的蛋白质作用机制的系统文献回顾
Asparuh Gardev,Derek J Hausenloy,Anton Pekcec
Asparuh Gardev
Following myocardial infarction (MI), reperfusion strategies ensure that blood flow is promptly restored to salvage the ischaemic myocardium. However, the sudden restoration of blood flow can inflict further damage to the ischaemic tissue, ...
Camystat: a high-throughput open-source software tool analysis of contractile cardiomyocytes recordings [0.03%]
一种新型高通量开源软件工具——CamYSta：用于分析心肌细胞收缩的记录数据
Marcin A Rojek,Piotr Lewandowski,Artur Morys-Magiera et al.
Marcin A Rojek et al.
AI-enabled motion artifact correction to replace emission- and excitation-ratiometry in cardiac optical mapping: A proof-of-concept study [0.03%]
基于人工智能的心脏光学描记图运动伪影校正技术：概念验证研究
Zhen Hua,Konstantinos Patlatzoglou,Vineesh Kappadan et al.
Zhen Hua et al.
β-adrenergic stimulation recruits additional contracting sarcomeres in cardiomyocytes [0.03%]
β肾上腺素能刺激使心肌细胞募集更多的收缩带节段sarcomeres）
Jia Li,Joakim Sundnes,Magnhild Sekse Erdal et al.
Jia Li et al.
Differential metabolomic prediction of outcomes in HFpEF and HFrEF: a prospective international multi-ethnic cohort study [0.03%]
HFpEF和HFrEF预后差异的代谢组学预测：前瞻性国际多民族队列研究
Lik Hang Wu,Leroy Sivappiragasam Pakkiri,Jasper Tromp et al.
Lik Hang Wu et al.
Aims: Metabolic dysregulation accompanies HF, yet coordinated biochemical shifts are rarely quantified for prognostication. We investigated whether early metabolic profiles predict morbidity and mortality in HF with prese...
Guillermo Luxán
Guillermo Luxán
Targeting the ALCAT1 enzyme for the treatment of pressure- overload hypertrophy [0.03%]
靶向ALCAT1酶以治疗压力超负荷心肌肥厚
Youhua Wang,Dandan Jia,Yuguang Shi
Youhua Wang
Aims: Pressure overload-induced heart failure is a major cause of fatality in patients with heart diseases. At present, there exists no highly effective treatment for this incapacitating condition. Cardiolipin (CL) is a m...
Plasma proteomics stratification identifies phospholamban R14del carriers at risk for disease progression [0.03%]
血浆蛋白质组学分层确定磷脂酰肌醇R14del携带者疾病进展风险
Frederik E Deiman,Taner Arslan,Remco de Brouwer et al.
Frederik E Deiman et al.
Aims: Incomplete penetrance is common in genetic cardiomyopathy, but poorly understood. Here, we investigate the circulating molecular signature in a cohort of patients with one specific phospholamban (PLN) p.Arg14del (R1...
Age-dependent dysregulation of collagen metabolism in primary cardiac fibroblasts in vitro [0.03%]
体外原代心脏成纤维细胞中与年龄相关的胶原代谢失调
Kalyani Pandya,Carlos J Alcaide-Corral,Timaeus E F Morgan et al.
Kalyani Pandya et al.
Introduction: Fibroblast-driven collagen remodelling is a key process in cardiac aging and fibrosis, yet how age and sex alter fibroblast collagen handling remains poorly characterized. This proof-of-concept study aimed t...