Local arterial administration of acidified malonate as an adjunct therapy to mechanical thrombectomy in ischaemic stroke [0.03%]
局部动脉给药丙酮酸单酯辅助治疗缺血性卒中机械取栓术
Jordan J Lee,Hiran A Prag,Karthik Chary et al.
Jordan J Lee et al.
Aims: Ischaemic stroke is increasingly treated by mechanical thrombectomy (MT) with the more rapid and complete reperfusion of the ischaemic tissue enhancing patient outcome, compared to recombinant tissue plasminogen act...
Delineation of a thrombin receptor-stimulated vascular smooth muscle cell transition generating cells in the plaque-stabilising fibrous cap [0.03%]
血栓素受体刺激的血管平滑肌细胞转换生成稳定纤维帽中的细胞
James C K Taylor,Matthew D Worssam,Sebnem Oc et al.
James C K Taylor et al.
Aims: Vascular smooth muscle cells (VSMCs) accumulate in atherosclerotic plaques and exhibit remarkable phenotypic plasticity, contributing to both plaque growth and stability. The plaque-stabilising fibrous cap is rich i...
The role of uremic toxin indoxyl sulfate in the pathophysiology of aortic valve stenosis [0.03%]
尿毒症毒素吲哚硫酸盐在主动脉瓣狭窄病理生理中的作用
Philip Düsing,Isabel Göbel,Ansgar Ackerschott et al.
Philip Düsing et al.
Aims: Chronic kidney disease (CKD) is closely associated with cardiovascular disease (CVD). This includes aortic valve stenosis (AS), one of the most common valve diseases among adults. CKD leads to the retention of uremi...
Systematic review and meta-analysis of respiratory viral triggers for acute myocardial infarction and stroke [0.03%]
系统评价和荟萃分析：呼吸道病毒触发急性心肌梗死和卒中的作用
Tu Q Nguyen,Diana Vlasenko,Aishwarya N Shetty et al.
Tu Q Nguyen et al.
Respiratory viral infections may trigger acute cardiovascular events. However, relative pathogen-specific associations are poorly understood, limiting optimal preventive recommendations. The aim of this study was to systematically review th...
Ingrid Larsson,Jiangming Sun,Shafqat Ahmad et al.
Ingrid Larsson et al.
Aims: Diet is a determinant of cardiovascular diseases (CVD) with coronary disease as predominant cause of pre-mature death. To analyse how diet was associated with coronary atherosclerosis, including plaque features. ...
An activator of PI3Kα restores cardioprotection from ischaemia/reperfusion injury in mice with coronary atherosclerosis or insulin resistance [0.03%]
PI3Kα活化剂可恢复小鼠缺血/再灌注损伤的保护作用：针对冠状动脉粥样硬化或胰岛素抵抗小鼠
Pelin Golforoush,Elias Sulaiman,David He et al.
Pelin Golforoush et al.
Background: In patients with coronary artery disease (CAD), morbidity and mortality from myocardial infarction remain high. Cardioprotective strategies such as Remote Ischaemic Conditioning (RIC) are highly effective in a...
CTRP7 as a molecular biomarker associating with responsiveness to pulmonary vasodilators: insights from human and animal studies in pulmonary arterial hypertension [0.03%]
CTRP7作为与肺动脉高压血管反应性相关的分子标志物：来自人类和动物研究的启示
Kaito Yamada,Taijyu Satoh,Nobuhiro Yaoita et al.
Kaito Yamada et al.
Aims: Pulmonary arterial hypertension (PAH) is a life-threatening condition. Although pulmonary vasodilators have shown promise in managing PAH, the improvement in prognosis is modest, partly because of a lack of biomarke...
Remodelling of supernumerary leaflet primordia leads to bicuspid aortic valve (BAV) caused by loss of primary cilia [0.03%]
由于原生纤毛丢失导致的多余瓣叶芽改建形成主动脉双叶瓣（BAV）
Ahlam Alqahtani,Lorraine Eley,Jake Newton et al.
Ahlam Alqahtani et al.
Aims: Bicuspid aortic valve (BAV), where two valve leaflets are found instead of the usual three, affects 1-2% of the general population and is associated with significant morbidity and mortality. Despite its frequency, t...
Premature cell senescence promotes vascular smooth muscle cell phenotypic modulation and resistance to re-differentiation [0.03%]
细胞衰老促进血管平滑肌表型转变并产生再分化的抵抗性
Anuradha Kaistha,Sebnem Oc,Abel Martin Garrido et al.
Anuradha Kaistha et al.
Aims: Human atherosclerotic plaque cells display DNA damage that if left unrepaired can promote premature cell senescence. Vascular smooth muscle cells (VSMCs) predisposed to senescence promote atherogenesis and features ...