Spike 1 protein of SARS-CoV-2 induces endothelial inflammation and vascular dysfunction through interferon ISG15-dependent mechanisms [0.03%]
SARS-CoV-2 Spike 1蛋白通过干扰素ISG15依赖性机制诱导内皮炎症和血管功能障碍
Francisco J Rios,Augusto C Montezano,Livia L Camargo et al.
Francisco J Rios et al.
Aims: Interferon (IFN) alpha (IFNα) and lambda3 (IFNλ3) constitute first line responses of immunity against SARS-CoV-2 infection by increasing interferon-stimulated genes (ISGs). Prolonged IFN production may exacerbate ...
Long-term outcomes of obstructive hypertrophic cardiomyopathy undergoing surgical myectomy: Impact of symptom severity at presentation [0.03%]
手术治疗梗阻性肥厚型心肌病长期疗效与初始症状严重程度的影响关系
Shada Jadam,Mohammed Abusafia,Sana Sultana et al.
Shada Jadam et al.
Surgical myectomy (SM), performed to relieve dynamic left ventricular outflow tract obstruction (LVOTO) in symptomatic obstructive hypertrophic cardiomyopathy (oHCM) patients provides improved quality of life and symptoms and excellent long...
The aorta in Marfan syndrome - from molecular mechanisms to mechanobiological dysfunction [0.03%]
马方综合征中的主动脉病变-从分子机制到力学生物学功能障碍
Jay D Humphrey,Dianna M Milewicz
Jay D Humphrey
Marfan syndrome (MFS) is an autosomal dominant connective tissue disorder that affects cardiovascular, musculoskeletal, and ocular tissues, with premature death often resulting from dissection of the thoracic aorta. MFS results from pathoge...
Trained immunity in monocytes and macrophages in atherosclerotic cardiovascular disease [0.03%]
单核细胞和巨噬细胞经训练免疫在动脉粥样硬化性心血管疾病中的作用
Xiaoyi Zhang,Mo Wang,Yunshan Wang et al.
Xiaoyi Zhang et al.
Monocytes and macrophages are critically involved in the pathogenesis of atherosclerotic cardiovascular disease (ASCVD). Accumulating evidence indicates that monocytes and macrophages can develop innate immune memory and exhibit sustained p...
Nidaa Mikail,Isabelle Glarner,Pimrapat Gebert et al.
Nidaa Mikail et al.
Machine learning-guided risk stratification for Long QT Syndrome genetic variants with hiPSC-derived cardiomyocytes [0.03%]
基于hiPSC来源的心肌细胞的机器学习指导的LQT遗传变异风险分类
Aleksandr Khudiakov,Manuela Mura,Federica Giannetti et al.
Aleksandr Khudiakov et al.
Aims: Long QT syndrome (LQTS) is a life-threatening genetic disorder characterized by prolonged QT intervals on electrocardiograms. Congenital forms are mostly associated with variants in the KCNQ1 and KCNH2 genes. Among ...
Shared proteomic landscape between arteriosclerosis and cardiovascular endpoints: a Mendelian randomization and observational study integrating AlphaFold3 for structural prediction [0.03%]
动脉粥样硬化与心血管事件的共有蛋白质组学特征：整合AlphaFold3结构预测的孟德尔随机化和观察性研究
Jingxian Huang,Devendra Meena,Margaux Achtari et al.
Jingxian Huang et al.
Aims: Atherosclerosis and arteriosclerosis are major contributors to cardiovascular disease (CVD), yet their shared and distinct molecular underpinnings remain incompletely understood. This study integrates proteomics, Ba...
Histone H3 lysine 18 lactylation-mediated SULF1 transcription promotes atherosclerosis by regulating endothelial-to-mesenchymal transition [0.03%]
组蛋白H3第18位赖氨酸乳酸化介导SULF1转录促进动脉粥样硬化发生发展及其机制研究
Zhenyu Guo,Wan Zhang,Xiaolong Shu et al.
Zhenyu Guo et al.
Aims: Endothelial-to-mesenchymal transition (EndMT) has emerged as a pathophysiological process responsible for various chronic vascular diseases, particularly atherosclerosis. However, the molecular pathways that govern ...
Disturbed flow induced targeting of nanomedicine to endothelial cells for effective atherosclerosis therapy [0.03%]
紊乱流体诱导的纳米药物靶向内皮细胞有效治疗动脉粥样硬化
Lin Fu,Meixi Quan,Ziyan Zhao et al.
Lin Fu et al.
Aims: Atherosclerotic plaques preferentially form at the vascular bifurcations and inner curvature of the aortic arch, where oscillatory shear stress (OSS) induces endothelial cell (EC) inflammation, which is a key driver...
Proteomic insights into bi-atrial remodelling in persistent atrial fibrillation [0.03%]
蛋白质组学视角下持续性房颤双心房重构的机制研究
Javier Barallobre-Barreiro,Manuel Mayr
Javier Barallobre-Barreiro