Inhibition of the extracellular enzyme A disintegrin and metalloprotease with thrombospondin motif 4 prevents cardiac fibrosis and dysfunction [0.03%]
组织金属蛋白酶TIMP-4抑制外源性酶A Disintegrin和金属蛋白酶，防止心脏纤维化和功能障碍
Maria Vistnes,Pugazendhi Murugan Erusappan,Athiramol Sasi et al.
Maria Vistnes et al.
Aims: Heart failure is a condition with high mortality rates, and there is a lack of therapies that directly target maladaptive changes in the extracellular matrix (ECM), such as fibrosis. We investigated whether the ECM ...
Salty secrets of the brain: the link between stress, salt, and hypertension [0.03%]
大脑的咸秘辛：压力、食盐和高血压的关系
Agnieszka H Ludwig-Słomczyńska,Tomasz J Guzik
Agnieszka H Ludwig-Słomczyńska
Protein arginine methyltransferase 5-mediated arginine methylation stabilizes Kruppel-like factor 4 to accelerate neointimal formation [0.03%]
精氨酸甲基转移酶5介导的精氨酸甲基化稳定Krüppel样因子4以促进新生内膜形成
He Liu,Xiaoliang Dong,Kunpeng Jia et al.
He Liu et al.
Aims: Accumulating evidence supports the indispensable role of protein arginine methyltransferase 5 (PRMT5) in the pathological progression of several human cancers. As an important enzyme-regulating protein methylation, ...
Transforming growth factor-β2 is associated with atherosclerotic plaque stability and lower risk for cardiovascular events [0.03%]
转化生长因子-β2与动脉粥样硬化斑块稳定性及较低的心血管事件风险相关
Andreas Edsfeldt,Pratibha Singh,Frank Matthes et al.
Andreas Edsfeldt et al.
Aims: Transforming growth factor-beta (TGF-β) exists in three isoforms TGF-β1, -β2, and -β3. TGF-β1 has been suggested to be important for maintaining plaque stability, yet the role of TGF-β2 and -β3 in atheroscler...
Are endothelial cell proliferation and mesenchymal transition as distinguishing characteristics of 3-week Sugen5416/hypoxia mice model? [0.03%]
内皮细胞增殖和间质转化是否是Sugen5416/低氧诱导小鼠模型21天时的特征表现？
Ruixuan Zheng,Tingting Xu,Ya Lin et al.
Ruixuan Zheng et al.
Human antigen R regulates autophagic flux by stabilizing autophagy-associated mRNA in calcific aortic valve disease [0.03%]
人类抗原R通过稳定钙化主动脉瓣疾病中自噬相关型mRNA来调节自噬通量
Juan Fang,Yi Qian,Jinyong Chen et al.
Juan Fang et al.
Aims: The incidence of calcific aortic valve disease (CAVD) has risen over the last decade and is expected to continue rising; however, pharmacological approaches have proven ineffective. In this study, we evaluated the r...
Mohammed Majid Akhtar,Victoria L Cammann,Christian Templin et al.
Mohammed Majid Akhtar et al.
Takotsubo syndrome (TTS) accounts for between 1 and 4% of cases presenting clinically as an acute coronary syndrome. It typically presents as a transient cardiac phenotype of left ventricular dysfunction with spontaneous recovery. More dram...
Response to: Are endothelial cell proliferation and mesenchymal transition as distinguishing characteristics of 3-week Sugen5416/hypoxia mice model? [0.03%]
对内皮细胞增殖和间质转化是否为Sugen5416/缺氧诱导小鼠模型特征的再探讨
Julie Rodor,Shiau-Haln Chen,Andrew H Baker
Julie Rodor
Xiaoli Wang,Yang Shen,Min Shang et al.
Xiaoli Wang et al.
Cardiovascular disease (CVD) is a serious health challenge, causing more deaths worldwide than cancer. The vascular endothelium, which forms the inner lining of blood vessels, plays a central role in maintaining vascular integrity and homeo...