Vascular smooth muscle cells specific deletion of angiopoietin-like protein 8 prevents angiotensin II-promoted hypertension and cardiovascular hypertrophy [0.03%]
血管平滑肌细胞特异性删除类血管生成素蛋白8预防血管紧张素II促进的高血压和心血管肥大
Xiaolu Jiao,Huahui Yu,Zhiyong Du et al.
Xiaolu Jiao et al.
Aims: Angiopoietin-like protein 8 (ANGPTL8) plays important roles in lipid metabolism, glucose metabolism, inflammation, and cell proliferation and migration. Clinical studies have indicated that circulating ANGPTL8 conce...
Endothelial CCRL2 induced by disturbed flow promotes atherosclerosis via chemerin-dependent β2 integrin activation in monocytes [0.03%]
血管内皮细胞CCRL2受紊乱流体剪切力诱导并通过化学吸引蛋白依赖的单核细胞β2整合素活化促进动脉粥样硬化形成
Chaojun Tang,Guona Chen,Fan Wu et al.
Chaojun Tang et al.
Aims: Chemoattractants and their cognate receptors are essential for leucocyte recruitment during atherogenesis, and atherosclerotic plaques preferentially occur at predilection sites of the arterial wall with disturbed f...
Cardiac-specific BACH1 ablation attenuates pathological cardiac hypertrophy by inhibiting the Ang II type 1 receptor expression and the Ca2+/CaMKII pathway [0.03%]
心脏特异性BACH1敲除通过抑制血管紧张素Ⅱ受体和钙信号通路减轻心肌肥厚
Xiangxiang Wei,Jiayu Jin,Jian Wu et al.
Xiangxiang Wei et al.
Aims: BACH1 is up-regulated in hypertrophic hearts, but its function in cardiac hypertrophy remains largely unknown. This research investigates the function and mechanisms of BACH1 in the regulation of cardiac hypertrophy...
Modulation of lncRNA links endothelial glycocalyx to vascular dysfunction of tyrosine kinase inhibitor [0.03%]
长链非编码RNA调节糖萼与酪氨酸激酶抑制剂血管功能障碍之间的联系
Sarath Babu Nukala,Jordan Jousma,Gege Yan et al.
Sarath Babu Nukala et al.
Aims: Novel cancer therapies leading to increased survivorship of cancer patients have been negated by a concomitant rise in cancer therapies-related cardiovascular toxicities. Sunitinib, a first line multi-receptor tyros...
Association of genetic risk and outcomes in patients with atrial fibrillation: interactions with early rhythm control in the EAST-AFNET4 trial [0.03%]
遗传风险与心房颤动患者的临床结局之间的关联：EAST-AFNET 4 研究中的早期节律控制的调节作用
Shinwan Kany,Christoph Al-Taie,Carolina Roselli et al.
Shinwan Kany et al.
Aims: The randomized Early Treatment of Atrial Fibrillation for Stroke Prevention Trial found that early rhythm control reduces cardiovascular events in patients with recently diagnosed atrial fibrillation (AF) compared w...
Randomized Controlled Trial
Cardiovascular research. 2023 Aug 7;119(9):1799-1810. DOI:10.1093/cvr/cvad027 2023
NLRP3 inflammasome and interleukin-1 contributions to COVID-19-associated coagulopathy and immunothrombosis [0.03%]
NLRP3炎性小体和白细胞介素-1在新冠肺炎相关凝血病与免疫性血栓形成中的作用
Nicola Potere,Evan Garrad,Yogendra Kanthi et al.
Nicola Potere et al.
Immunothrombosis-immune-mediated activation of coagulation-is protective against pathogens, but excessive immunothrombosis can result in pathological thrombosis and multiorgan damage, as in severe coronavirus disease 2019 (COVID-19). The NA...
Cardiovascular complications in chronic kidney disease: a review from the European Renal and Cardiovascular Medicine Working Group of the European Renal Association [0.03%]
慢性肾脏病的心血管并发症：欧洲肾病和心血管医学工作组的综述文章
Carmine Zoccali,Francesca Mallamaci,Marcin Adamczak et al.
Carmine Zoccali et al.
Chronic kidney disease (CKD) is classified into five stages with kidney failure being the most severe stage (stage G5). CKD conveys a high risk for coronary artery disease, heart failure, arrhythmias, and sudden cardiac death. Cardiovascula...
Claudia Monaco,Lea Dib
Claudia Monaco
Macrophage angiotensin-converting enzyme reduces atherosclerosis by increasing peroxisome proliferator-activated receptor α and fundamentally changing lipid metabolism [0.03%]
巨噬细胞血管紧张素转化酶通过增加过氧化物酶体增殖激活受体α和根本改变脂质代谢来减少动脉粥样硬化
DuoYao Cao,Zakir Khan,Xiaomo Li et al.
DuoYao Cao et al.
Aims: The metabolic failure of macrophages to adequately process lipid is central to the aetiology of atherosclerosis. Here, we examine the role of macrophage angiotensin-converting enzyme (ACE) in a mouse model of PCSK9-...
Professor Ryszard Jerzy Gryglewski: pioneer of pharmacology of vascular endothelium [0.03%]
血管内皮药理学先驱Ryszard Jerzy Gryglewski教授
Stefan Chlopicki,Rafal Olszanecki,Rod J Flower
Stefan Chlopicki