Smoke on the blood stream: novel insights in cigarette smoke-induced atherosclerosis and plaque erosion [0.03%]
烟草烟雾导致动脉粥样硬化和斑块侵蚀的新见解
Henning Morawietz
Henning Morawietz
BMAL1 regulates cell cycle progression and angiogenesis of endothelial cells [0.03%]
BMAL1调节内皮细胞的细胞周期进程和血管生成
Inna Rabinovich-Nikitin,Lorrie A Kirshenbaum
Inna Rabinovich-Nikitin
Lorenzo Da Dalt,Ainara G Cabodevilla,Ira J Goldberg et al.
Lorenzo Da Dalt et al.
A fine balance between uptake, storage, and the use of high energy fuels, like lipids, is crucial in the homeostasis of different metabolic tissues. Nowhere is this balance more important and more precarious than in the heart. This highly e...
Single-cell profiling reveals age-associated immunity in atherosclerosis [0.03%]
单细胞测序揭示动脉粥样硬化相关的年龄免疫特征
Virginia Smit,Jill de Mol,Frank H Schaftenaar et al.
Virginia Smit et al.
Aims: Aging is a dominant driver of atherosclerosis and induces a series of immunological alterations, called immunosenescence. Given the demographic shift towards elderly, elucidating the unknown impact of aging on the i...
Cardiorenal interactions in heart failure - insights from recent therapeutic advances [0.03%]
心力衰竭中心肾相互作用的见解——来自最近治疗进展的启示
Kevin Damman,Jeffrey Testani
Kevin Damman
Heart failure is a syndrome that may develop when cardiovascular disease progresses or is insufficiently treated and associated with a poor quality of life, high mortality rates and increased health care expenditures. Prevention and treatme...
Non-alcoholic fatty liver disease: pathophysiological concepts and treatment options [0.03%]
非酒精性脂肪肝病：病理生理概念及治疗选择
Christoph Grander,Felix Grabherr,Herbert Tilg
Christoph Grander
The prevalence of non-alcoholic fatty liver disease (NAFLD) is continually increasing due to the global obesity epidemic. NAFLD comprises a systemic metabolic disease accompanied frequently by insulin resistance and hepatic and systemic inf...
Pre-emptive iron supplementation prevents myocardial iron deficiency and attenuates adverse remodelling after myocardial infarction [0.03%]
术前补铁可预防心肌梗死后的心肌铁缺乏并改善不良重构
Bomee Chung,Yong Wang,Marleen Thiel et al.
Bomee Chung et al.
Aims: Heart failure (HF) after myocardial infarction (MI) is a major cause of morbidity and mortality. We sought to investigate the functional importance of cardiac iron status after MI and the potential of pre-emptive ir...
Immune profiling of murine cardiac leukocytes identifies triggering receptor expressed on myeloid cells 2 as a novel mediator of hypertensive heart failure [0.03%]
小鼠心脏白细胞免疫特征鉴定髓系细胞表达的触发受体2是高血压心力衰竭的新介导因素
Charles Duncan Smart,Daniel J Fehrenbach,Jean W Wassenaar et al.
Charles Duncan Smart et al.
Aims: Heart failure with preserved ejection fraction (HFpEF) is characterized by diastolic dysfunction, microvascular dysfunction, and myocardial fibrosis with recent evidence implicating the immune system in orchestratin...
Thrombin-activated interleukin-1α drives atherogenesis, but also promotes vascular smooth muscle cell proliferation and collagen production [0.03%]
凝血酶活化的白细胞介素-1α驱动动脉粥样硬化生成，但也促进血管平滑肌细胞增殖和胶原蛋白产生
Laura C Burzynski,Alejandra Morales-Maldonado,Amanda Rodgers et al.
Laura C Burzynski et al.
Aims: Atherosclerosis is driven by multiple processes across multiple body systems. For example, the innate immune system drives both atherogenesis and plaque rupture via inflammation, while coronary artery-occluding thro...