A machine learning based approach to identify carotid subclinical atherosclerosis endotypes [0.03%]
基于机器学习的识别颈动脉亚临床动脉粥样硬化表型的方法
Qiao Sen Chen,Otto Bergman,Louise Ziegler et al.
Qiao Sen Chen et al.
Aims: To define endotypes of carotid subclinical atherosclerosis. Methods and results: We integrated demographic, clinical, and molecul...
Positron emission tomography imaging of inflammation in diabetes mellitus [0.03%]
糖尿病患者的炎症正电子发射断层扫描图像学研究
Neil J Craig,Marc R Dweck
Neil J Craig
Pathophysiology of the right ventricle in health and disease: an update [0.03%]
健康与疾病状态下的右心室病理生理学研究进展
Khodr Tello,Robert Naeije,Frances de Man et al.
Khodr Tello et al.
The contribution of the right ventricle (RV) to cardiac output is negligible in normal resting conditions when pressures in the pulmonary circulation are low. However, the RV becomes relevant in healthy subjects during exercise and definite...
Ribonucleicacid interference or small molecule inhibition of Runx1 in the border zone prevents cardiac contractile dysfunction following myocardial infarction [0.03%]
干扰素或小分子抑制梗死心肌邻近区Runx1可防止心脏收缩功能障碍
Tamara P Martin,Eilidh A MacDonald,Ashley Bradley et al.
Tamara P Martin et al.
Aims: Myocardial infarction (MI) is a major cause of death worldwide. Effective treatments are required to improve recovery of cardiac function following MI, with the aim of improving patient outcomes and preventing progr...
Has genetic disposition implications for treatment decisions in atrial fibrillation? [0.03%]
遗传易感性对房颤治疗决策有影响吗？
Felix Bourier,Heribert Schunkert
Felix Bourier
Chronic SIRT1 supplementation in diabetic mice improves endothelial function by suppressing oxidative stress [0.03%]
SIRT1慢性补充通过抑制氧化应激改善糖尿病小鼠内皮功能
Kangmin Yang,Srividya Velagapudi,Alexander Akhmedov et al.
Kangmin Yang et al.
Aims: Enhancing SIRT1 activity exerts beneficial cardiovascular effects. In diabetes, plasma SIRT1 levels are reduced. We aimed to investigate the therapeutic potential of chronic recombinant murine SIRT1 (rmSIRT1) supple...
Integrin beta-like 1 mediates fibroblast-cardiomyocyte crosstalk to promote cardiac fibrosis and hypertrophy [0.03%]
整合素β_like_1介导成纤维细胞和心肌细胞的相互作用促进心脏纤维化和肥大
XiaoQiang Chen,XinTao Li,XiaoYu Wu et al.
XiaoQiang Chen et al.
Aims: Crosstalk between fibroblasts and cardiomyocytes (CMs) plays a critical role in cardiac remodelling during heart failure (HF); however, the underlying molecular mechanisms remain obscure. Recently, a secretory prote...
Tissue-specific differences in the assembly of mitochondrial Complex I are revealed by a novel ENU mutation in ECSIT [0.03%]
一种新型ENU突变体ECSIT揭示线粒体Complex I组装的组织特异性差异
Thomas Nicol,Sara Falcone,Andrew Blease et al.
Thomas Nicol et al.
Aims: Mitochondrial Complex I assembly (MCIA) is a multi-step process that necessitates the involvement of a variety of assembly factors and chaperones to ensure that the final active enzyme is correctly assembled. The ro...
Lipocalin 10 is essential for protection against inflammation-triggered vascular leakage by activating LDL receptor-related protein 2-slingshot homologue 1 signalling pathway [0.03%]
脂川蛋白10通过激活低密度脂蛋白受体相关蛋白2-Slc信号通路对抗炎症触发的血管渗漏起关键作用
Hongyan Zhao,Peng Wang,Xiaohong Wang et al.
Hongyan Zhao et al.
Aims: Systemic inflammation occurs commonly during many human disease settings and increases vascular permeability, leading to organ failure, and lethal outcomes. Lipocalin 10 (Lcn10), a poorly characterized member of the...