Mitochondrial pannexin1 controls cardiac sensitivity to ischaemia/reperfusion injury [0.03%]
线粒体连接蛋白1控制心脏对缺血/再灌注损伤的敏感性
Olga M Rusiecka,Filippo Molica,Morten S Nielsen et al.
Olga M Rusiecka et al.
Aims: No effective therapy is available in clinics to protect the heart from ischaemia/reperfusion (I/R) injury. Endothelial cells are activated after I/R, which may drive the inflammatory response by releasing ATP throug...
p55γ degrades RIP3 via MG53 to suppress ischaemia-induced myocardial necroptosis and mediates cardioprotection of preconditioning [0.03%]
p55γ通过MG53降解RIP3来抑制缺血诱导的心肌坏死并介导预处理的心脏保护作用
Zhenyan Li,Rilei Dai,Min Chen et al.
Zhenyan Li et al.
Aims: Regulated necrosis (necroptosis) and apoptosis are important biological features of myocardial infarction, ischaemia-reperfusion (I/R) injury, and heart failure. However, the molecular mechanisms underlying myocardi...
Sodium-glucose cotransporter 2 inhibitor canagliflozin alleviates vascular calcification through suppression of nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3 inflammasome [0.03%]
钠葡萄糖共转运蛋白2抑制剂卡格列净通过抑制核苷酸结合寡聚化结构AINLRICHLEUCINE-RICHREPEAT含有吡啶结构域3型炎性小体缓解血管钙化
An Chen,Zirong Lan,Li Li et al.
An Chen et al.
Aims: Vascular calcification (VC) is prevalent in pathological processes such as diabetes, chronic kidney disease (CKD), and atherosclerosis, but effective therapies are still lacking by far. Canagliflozin (CANA), a sodiu...
Integrative human atrial modelling unravels interactive protein kinase A and Ca2+/calmodulin-dependent protein kinase II signalling as key determinants of atrial arrhythmogenesis [0.03%]
整合型人房室建模揭示了蛋白激酶A和Ca2+/钙调素依赖性蛋白激酶II信号作为房颤的关键决定因素交互作用蛋白质 kinases A 和 Ca2+/calmodulin-dependent protein kinases II 信号作为房颤的关键决定因素交互作用
Haibo Ni,Stefano Morotti,Xianwei Zhang et al.
Haibo Ni et al.
Aims: Atrial fibrillation (AF), the most prevalent clinical arrhythmia, is associated with atrial remodelling manifesting as acute and chronic alterations in expression, function, and regulation of atrial electrophysiolog...
FAM210A regulates mitochondrial translation and maintains cardiac mitochondrial homeostasis [0.03%]
FAM210A调节线粒体翻译并维持心肌线粒体稳态
Jiangbin Wu,Kadiam C Venkata Subbaiah,Omar Hedaya et al.
Jiangbin Wu et al.
Aims: Mitochondria play a vital role in cellular metabolism and energetics and support normal cardiac function. Disrupted mitochondrial function and homeostasis cause a variety of heart diseases. Fam210a (family with sequ...
Aortic valve calcification is promoted by interleukin-8 and restricted through antagonizing CXC motif chemokine receptor 2 [0.03%]
白细胞介素8促进主动脉瓣钙化通过拮抗C-X-C基序趋化因子受体2限制其进展
Kawthar Dhayni,Yuthiline Chabry,Lucie Hénaut et al.
Kawthar Dhayni et al.
Aims: Inflammatory cytokines play a critical role in the progression of calcific aortic valve disease (CAVD), for which there is currently no pharmacological treatment. The aim of this study was to test the hypothesis tha...
E-cigarettes and arrhythmogenesis: a comprehensive review of pre-clinical studies and their clinical implications [0.03%]
电子烟与心律失常：前期临床研究及其临床意义的全面回顾
Carson A Jones,Michael J Wallace,Priya Bandaru et al.
Carson A Jones et al.
Electronic cigarette use has grown exponentially in recent years, and while their popularity has increased, the long-term effects on the heart are yet to be fully studied and understood. Originally designed as devices to assist with those t...
LncRNA-encoded peptides: unveiling their significance in cardiovascular physiology and pathology-current research insights [0.03%]
长链非编码RNA编码肽在心血管生理和病理中的意义及当前研究进展
Li Zhang,Mi Tang,Haoyang Diao et al.
Li Zhang et al.
Long non-coding RNAs (lncRNAs), which are RNA transcripts exceeding 200 nucleotides were believed to lack any protein-coding capacity. But advancements in -omics technology have revealed that some lncRNAs have small open reading frames (sOR...
Donor circadian clock influences the long-term survival of heart transplantation by immunoregulation [0.03%]
供体昼夜钟通过免疫调节影响心脏移植的长期存活率
Wai Yen Yim,Tixiusi Xiong,Bingchuan Geng et al.
Wai Yen Yim et al.
Aims: Circadian clocks play important role in immunoregulation. We aimed to investigate cardiac circadian clock specific pathways and compare cardiac grafts procured at different timing on survival after transplantation t...
Genetic variation in solute carrier family 5 member 2 mimicking sodium-glucose co-transporter 2-inhibition and risk of cardiovascular disease and all-cause mortality: reduced risk not explained by lower plasma glucose [0.03%]
类似钠-葡萄糖同向转运蛋白2抑制的溶质载体家族成员5成员2基因变异与心血管疾病和全因死亡率风险降低：并非由血糖水平下降所致
Louise E Bechmann,Frida Emanuelsson,Børge G Nordestgaard et al.
Louise E Bechmann et al.
Aims: Treatment with sodium-glucose co-transporter 2 (SGLT2)-inhibitors reduces the risk of cardiovascular disease and mortality, but the mechanism is unclear. We hypothesized that a functional genetic variant in solute c...