Doxorubicin-induced cardiovascular toxicity: a longitudinal evaluation of functional and molecular markers [0.03%]
多柔比星诱导的心血管毒性：功能性分子标志物的纵向评估
Matthias Bosman,Dustin Krüger,Charles Van Assche et al.
Matthias Bosman et al.
Aims: Apart from cardiotoxicity, the chemotherapeutic doxorubicin (DOX) induces vascular toxicity, represented by arterial stiffness and endothelial dysfunction. Both parameters are of interest for cardiovascular risk str...
Erratum to: Thrombin-activated interleukin-1α drives atherogenesis, but also promotes vascular smooth muscle cell proliferation and collagen production [0.03%]
订正：凝血酶活化的白细胞介素-1α驱动动脉粥样硬化，但也促进血管平滑肌细胞增殖和胶原生成
Published Erratum
Cardiovascular research. 2024 Feb 27;120(1):121. DOI:10.1093/cvr/cvad128 2024
C5a-C5aR1 induces endoplasmic reticulum stress to accelerate vascular calcification via PERK-eIF2α-ATF4-CREB3L1 pathway [0.03%]
补体C5a-C5aR1通过PERK-eIF2α-ATF4-CREB3L1通路诱导内质网应激促进血管钙化
Aiting Liu,Zhenwei Chen,Xiaoxue Li et al.
Aiting Liu et al.
Aims: Vascular calcification (VC) predicts the morbidity and mortality in cardiovascular diseases. Vascular smooth muscle cells (VSMCs) osteogenic transdifferentiation is the crucial pathological basis for VC. To date, th...
Triggering receptor expressed on myeloid cells 2 restricts cardiac inflammation and hypertrophy in hypertensive mice [0.03%]
触发性表达于髓系细胞2限制高血压小鼠心脏炎症和肥大
Murilo Delgobo,Stefan Frantz
Murilo Delgobo
Inhibition of galectin-3 post-infarction impedes progressive fibrosis by regulating inflammatory profibrotic cascades [0.03%]
缺血后抑制半乳糖凝集素-3通过调节促纤维化炎性级联反应来阻碍心肌病理性重构进展
Xiaoyin Wang,Meenakshi Gaur,Khalid Mounzih et al.
Xiaoyin Wang et al.
Aims: Acute myocardial infarction (MI) causes inflammation, collagen deposition, and reparative fibrosis in response to myocyte death and, subsequently, a pathological myocardial remodelling process characterized by exces...
Activation of endothelial TRPM2 exacerbates blood-brain barrier degradation in ischemic stroke [0.03%]
缺血性卒中时内皮细胞TRPM2通道激活加重血脑屏障破坏
Pengyu Zong,Jianlin Feng,Cindy X Li et al.
Pengyu Zong et al.
Aims: Damage of the blood-brain barrier (BBB) is a hallmark of brain injury during the early stages of ischemic stroke. The subsequent endothelial hyperpermeability drives the initial pathological changes and aggravates n...
Targeting endothelial vascular cell adhesion molecule-1 in atherosclerosis: drug discovery and development of vascular cell adhesion molecule-1-directed novel therapeutics [0.03%]
针对动脉粥样硬化血管内皮细胞黏附分子-1的药物发现与血管细胞黏附分子-1导向新药研发
Jessica R Pickett,Yuao Wu,Lucia F Zacchi et al.
Jessica R Pickett et al.
Vascular cell adhesion molecule-1 (VCAM-1) has been well established as a critical contributor to atherosclerosis and consequently as an attractive therapeutic target for anti-atherosclerotic drug candidates. Many publications have demonstr...
Marius Wits,Clarissa Becher,Frances de Man et al.
Marius Wits et al.
Pulmonary arterial hypertension (PAH) is a rare cardiovascular disorder leading to pulmonary hypertension and, often fatal, right heart failure. Sex differences in PAH are evident, which primarily presents with a female predominance and inc...
Gerd Heusch
Gerd Heusch