Associations of the inflammasome-dependent cytokine IL-18 with risk of coronary heart disease [0.03%]
炎症小体依赖性细胞因子IL-18与冠心病发病风险的关系
Harry Björkbacka,Isabel Gonçalves,Gunnar Engström et al.
Harry Björkbacka et al.
Aims: Inflammasome activation has emerged as a promising therapeutic target to reduce residual cardiovascular risk in patients on guideline lipid-lowering therapy. IL-1β and IL-6 have been intensively studied, whereas th...
Targeting endothelial to mesenchymal transition in atherosclerosis [0.03%]
动脉粥样硬化中内皮细胞向间充质细胞转分化的作用及机制研究进展
Giorgia Ciliberti,Marco Sachse,Konstantinos Stellos
Giorgia Ciliberti
Association of HDL cholesterol, apolipoprotein AI, and E concentrations with foetal growth and placental insufficiency [0.03%]
高密度脂蛋白胆固醇、载脂蛋白AI和E浓度与胎儿生长及胎盘功能不全的关系
Rikke Mohr Lytsen,Sofie Taageby Nielsen,Nina Strandkjær et al.
Rikke Mohr Lytsen et al.
Aims: Foetal cholesterol is primarily carried by high-density lipoprotein (HDL) enriched with apolipoprotein E (apoE) and the fetus depends on a maternal-placental supply in early gestation until foetal de novo synthesis ...
Plasma proteomics maps molecular bridges from depression to incident CHD: 15-year proteomic trajectories and enhanced prediction [0.03%]
血浆蛋白质组学绘制了从抑郁到首次发生冠心病的分子桥梁：15年的蛋白质组学轨迹和增强预测
Chunying Fu,Bo Xie,Juan Li et al.
Chunying Fu et al.
Human induced pluripotent stem cell cardiomyocytes for risk stratification of patients with LQT syndrome - ready for practice? [0.03%]
用由诱导多能干细胞分化而来的原条心肌细胞对LQT综合征患者进行风险分层-可以用于临床实践吗？
Thomas Eschenhagen
Thomas Eschenhagen
Hypoxia differentially affects coronary vessel formation during heart development [0.03%]
缺氧对心脏发育过程中冠状血管形成的影响不同
Sophie Payne,Susann Bruche,Dorota Szumska et al.
Sophie Payne et al.
Aims: The coronary vessel system is a dense and diverse network of arteries, veins and capillaries formed by endothelial cells from a variety of sources. While hypoxia is a known stimulus for angiogenic sprouting generall...
STING promotes CD8 T-cell cardiotropism and fibrosis from distinct cellular compartments in doxorubicin cardiomyopathy [0.03%]
STING通过不同细胞区室促进多柔比星心肌病小鼠模型中CD8+t细胞向心脏浸润及纤维化发生
Abraham L Bayer,Maria Antonia Zambrano,Ramona Emig et al.
Abraham L Bayer et al.
Aims: Doxorubicin (DR), a widely prescribed chemotherapy, has an unfortunate side effect of cardiotoxicity resulting from DNA damage and cardiac cell death. Cardiac atrophy, fibrosis and a cytotoxic CD8+ T-cell response, ...
Hypoxia suppresses platelet activity through GPVI downregulation but paradoxically enhances arterial thrombosis via elevated vWF [0.03%]
缺氧通过下调GPVI抑制血小板活化但通过上调vWF增强动脉血栓形成
Vishwanath Jha,Jae-Sung Kim,Muteen Ahmed et al.
Vishwanath Jha et al.
Aims: Hypoxia is associated with thrombosis, yet its effects on platelet function remain controversial due to variable experimental conditions. In this study, we systematically examined the effects of graded normobaric hy...
Mahmoud H Elbatreek,David J Lefer
Mahmoud H Elbatreek
Gene expression profiles of carotid plaques differ between patients with amaurosis fugax and those with cerebral transient ischemic attack or stroke [0.03%]
颈动脉斑块基因表达谱在一过性黑蒙患者中与其他脑部短暂性缺血发作或卒中的患者不同
Tian Lan,Floor B H van der Zalm,Kaylin C A Palm et al.
Tian Lan et al.
Aims: In patients with atherosclerotic internal carotid artery stenosis, the risk of subsequent ischemic stroke is higher in those presenting with a cerebral transient ischemic attack (TIA) than in those with amaurosis fu...