The pioneer factor, ETV2, regulates networks to specify the embryonic endothelial lineage [0.03%]
先锋因子ETV2调控网络确定胚胎内皮谱系Specification of the embryonic endothelial lineage by the pioneer factor ETV2
Satyabrata Das,Xiao Ma,Kidus Hailemariam et al.
Satyabrata Das et al.
Aims: Mechanisms that govern the emergence of multiple cell lineages from common mesodermal progenitors remain incompletely understood due to their limited number and accessibility. The pioneer transcription factor ETV2 s...
From sex hormone decrease to hormonal treatment: impacts on cardiovascular risk with ageing [0.03%]
从性激素下降到荷尔蒙治疗：老龄化对心血管风险的影响
Coralie Fontaine,Anna Gosset,Morgane Davezac et al.
Coralie Fontaine et al.
Ageing plays a critical role in the deterioration of artery function and structure, and clearly represents the first cardiovascular (CV) risk factor in men but also in women. Coronary and cerebral arteries are particularly prone to atheroma...
Aging in the vascular system: lessons from mechanobiology, computational approaches and oxidative stress [0.03%]
血管系统的衰老：来自力学生物学、计算方法和氧化应激的启示
Patrick Lacolley,Stéphane Avril,Tamás Gáll et al.
Patrick Lacolley et al.
Vascular aging is considered now to be the first factor of multiorgan aging in what is called "the vascular theory of aging". Clinical understanding of vascular aging has long been limited to arterial hypertension and arterial stiffness. Th...
Patrick Lacolley,María Mittelbrunn,Stefanie Dimmeler
Patrick Lacolley
A comprehensive review/expert statement on environmental risk factors of cardiovascular disease [0.03%]
心血管疾病环境风险因素的全面回顾/专家声明
Thomas Münzel,Mette Sørensen,Jos Lelieveld et al.
Thomas Münzel et al.
Cardiovascular disease (CVD) is the leading cause of mortality globally, with over 20 million deaths each year. While traditional risk factors-such as hypertension, diabetes, smoking, and poor diet-are well-established, emerging evidence un...
Novel flow cytometry-based method for isolating and characterizing human coronary artery endothelial cells from catheter wires in coronary disease and microvascular dysfunction [0.03%]
一种新型流式细胞仪方法用于冠状动脉疾病和微血管功能障碍中从导丝中分离和表征人冠状动脉内皮细胞
Philip Stapmanns,Youssef S Abdelwahed,Christopher Wolfram et al.
Philip Stapmanns et al.
Prabhash Kumar Jha,Masanori Aikawa,Elena Aikawa
Prabhash Kumar Jha
YY1 regulates vascular resistance and blood pressure dynamics through epigenetic control of m6A RNA modifications in VSMCs [0.03%]
YY1通过表观遗传调控VSMC中mRNA的m6A修饰来调节血管张力和血压动态变化
Wenchu Ye,Wentao Gao,Cheng Kiu Ho et al.
Wenchu Ye et al.
Aims: Recent GWAS analysis has identified YY1 as a novel locus associated with blood pressure traits; however, whether YY1 directly controls vasoreactivity remains unknown. The principal function of vascular smooth muscle...
Phenotypic spectrum of cardiac conduction disturbance and cardiomyopathy linked to titin canonical splice-site variants [0.03%]
经titin标准拼接位点变异的传导和心肌病的表型谱系
Taisuke Ishikawa,Hiroki Kimoto,Akiko Seki et al.
Taisuke Ishikawa et al.
Aims: Truncating variations in the titin gene (TTNtv) are the most common genetic cause of dilated cardiomyopathy (DCM) and have been implicated in various arrhythmic and heart failure phenotypes. Nonetheless, predicting ...
ULK1 phosphorylation and cardiomyocyte senescence: unveiling a molecular nexus in cardiac aging [0.03%]
ULK1磷酸化与心肌细胞衰老：揭示心脏老化中的分子纽带
Maria Cristina Vinci
Maria Cristina Vinci