TNF-α protects from exacerbated myocarditis and cardiac death by suppressing expansion of activated heart-reactive CD4+ T cells [0.03%]
肿瘤坏死因子α通过抑制活化的心脏反应性CD4+T细胞的扩增来抵抗心肌炎和心脏死亡
Filip Rolski,Karolina Tkacz,Kazimierz Węglarczyk et al.
Filip Rolski et al.
Aims: Tumour necrosis factor α (TNF-α) represents a classical pro-inflammatory cytokine, and its increased levels positively correlate with the severity of many cardiovascular diseases. Surprisingly, some heart failure ...
Updating the paradigm: inflammation as a targetable modulator of medial vascular calcification [0.03%]
更新范式：以炎症作为可调节的内膜血管钙化因素
Mandy E Turner,Elena Aikawa
Mandy E Turner
Should we resurrect acetazolamide as a diuretic for congestion due to heart failure? [0.03%]
阿米洛利能否重新作为心衰所致淤血的利尿剂？
Joe J Cuthbert,John G F Cleland
Joe J Cuthbert
Prdm16 mutation determines sex-specific cardiac metabolism and identifies two novel cardiac metabolic regulators [0.03%]
PRDM16突变决定性别特异性心脏代谢并鉴定两种新的心脏代谢调节因子
Jirko Kühnisch,Simon Theisen,Josephine Dartsch et al.
Jirko Kühnisch et al.
Aims: Mutation of the PRDM16 gene causes human dilated and non-compaction cardiomyopathy. The PRDM16 protein is a transcriptional regulator that affects cardiac development via Tbx5 and Hand1, thus regulating myocardial s...
Empagliflozin improves cardiac energetics during ischaemia/reperfusion by directly increasing cardiac ketone utilization [0.03%]
恩格列净通过直接增加酮体利用改善缺血/再灌注时的心肌能量代谢
Dylan Chase,Thomas R Eykyn,Michael J Shattock et al.
Dylan Chase et al.
Aims: Empagliflozin (EMPA), a potent inhibitor of the renal sodium-glucose cotransporter 2 and an effective treatment for Type 2 diabetes, has been shown to have cardioprotective effects, independent of improved glycaemic...
Targeting galectin-3 in myocardial infarction: a unique opportunity for biomarker-guided therapy [0.03%]
靶向心肌梗死中的半乳糖凝集素-3：生物标志物引导治疗的独特机会
Nikolaos G Frangogiannis
Nikolaos G Frangogiannis
Soumaya Ben-Aicha,Borja Ibañez
Soumaya Ben-Aicha
Circulating GDF11 exacerbates myocardial injury in mice and associates with increased infarct size in humans [0.03%]
循环中的GDF11可加重小鼠的心肌损伤，并与人类的增加的梗死面积相关
Simon Kraler,Carolina Balbi,Daria Vdovenko et al.
Simon Kraler et al.
Aims: The heart rejuvenating effects of circulating growth differentiation factor 11 (GDF11), a transforming growth factor-β superfamily member that shares 90% homology with myostatin (MSTN), remains controversial. Here,...
Targeted activation of human ether-à-go-go-related gene channels rescues electrical instability induced by the R56Q+/- long QT syndrome variant [0.03%]
人以太飘渺相关基因通道的靶向激活可缓解R56Q+/−长QT综合征变异引起的电不稳定性
Ravichandra Venkateshappa,Diana V Hunter,Priya Muralidharan et al.
Ravichandra Venkateshappa et al.
Aims: Long QT syndrome type 2 (LQTS2) is associated with inherited variants in the cardiac human ether-à-go-go-related gene (hERG) K+ channel. However, the pathogenicity of hERG channel gene variants is often uncertain. ...