Contractility measurements for cardiotoxicity screening with ventricular myocardial slices of pigs [0.03%]
用于心脏毒理学筛选的猪心室肌片收缩性测量
Runzhu Shi,Marius Reichardt,Dominik J Fiegle et al.
Runzhu Shi et al.
Aims: Cardiotoxicity is one major reason why drugs do not enter or are withdrawn from the market. Thus, approaches are required to predict cardiotoxicity with high specificity and sensitivity. Ideally, such methods should...
The inhibition of inner mitochondrial fusion in hepatocytes reduces non-alcoholic fatty liver and improves metabolic profile during obesity by modulating bile acid conjugation [0.03%]
肝细胞内线粒体融合抑制通过调节胆汁酸结合减少非酒精性脂肪肝并改善肥胖期间的代谢谱
Lorenzo Da Dalt,Annalisa Moregola,Monika Svecla et al.
Lorenzo Da Dalt et al.
Aims: Mitochondria are plastic organelles that continuously undergo biogenesis, fusion, fission, and mitophagy to control cellular energy metabolism, calcium homeostasis, hormones, sterols, and bile acids (BAs) synthesis....
Plasma adiponectin levels and risk of heart failure, atrial fibrillation, aortic valve stenosis, and myocardial infarction: large-scale observational and Mendelian randomization evidence [0.03%]
有关心力衰竭、房颤、主动脉瓣狭窄和心肌梗死的血浆脂联素水平与风险：大规模观察研究及孟德尔随机化证据
Maria Booth Nielsen,Yunus Çolak,Marianne Benn et al.
Maria Booth Nielsen et al.
Aims: Adiponectin may play an important protective role in heart failure and associated cardiovascular diseases. We hypothesized that plasma adiponectin is associated observationally and causally, genetically with risk of...
Exercise-induced circular RNA circUtrn is required for cardiac physiological hypertrophy and prevents myocardial ischaemia-reperfusion injury [0.03%]
运动诱导的环状RNA circUtrn 通过促进心脏生理肥大来预防心肌缺血再灌注损伤
Lijun Wang,Jingyi Feng,Xing Feng et al.
Lijun Wang et al.
Aims: Regular exercise training benefits cardiovascular health and effectively reduces the risk for cardiovascular disease. Circular RNAs (circRNAs) play important roles in cardiac pathophysiology. However, the role of ci...
Deletion of adipocyte NOS3 potentiates high-fat diet-induced hypertension and vascular remodelling via chemerin [0.03%]
删除脂肪细胞NOS3通过Chemerin促进高脂饮食诱导的高血压和血管重塑
Andy W C Man,Yawen Zhou,Gisela Reifenberg et al.
Andy W C Man et al.
Aims: Obesity is an epidemic that is a critical contributor to hypertension and other cardiovascular diseases. Current paradigms suggest that endothelial nitric oxide synthase (eNOS/NOS3) in the vessel wall is the primary...
Point mutations in RyR2 Ca2+-binding residues of human cardiomyocytes cause cellular remodelling of cardiac excitation contraction-coupling [0.03%]
人心脏细胞中RYR2钙结合残基点突变导致心肌兴奋收缩偶联的细胞重塑
Yanli Xia,Xiao-Hua Zhang,Naohiro Yamaguchi et al.
Yanli Xia et al.
Aims: CRISPR/Cas9 gene edits of cardiac ryanodine receptor (RyR2) in human-induced pluripotent stem cell derived cardiomyocytes (hiPSC-CMs) provide a novel platform for introducing mutations in RyR2 Ca2+-binding residues ...
RBPMS regulates cardiomyocyte contraction and cardiac function through RNA alternative splicing [0.03%]
RNA选择性剪接调节因子RBPMS通过调控心肌细胞收缩维持心脏功能
Peiheng Gan,Zhaoning Wang,Svetlana Bezprozvannaya et al.
Peiheng Gan et al.
Aims: RNA binding proteins play essential roles in mediating RNA splicing and are key post-transcriptional regulators in the heart. Our recent study demonstrated that RBPMS (RNA binding protein with multiple splicing) is ...
Efficacy of pharmacological and interventional treatment for resistant hypertension: a network meta-analysis [0.03%]
顽固性高血压的药物与介入治疗疗效的网状meta分析研究
Zhejia Tian,Clara Vollmer Barbosa,Hannah Lang et al.
Zhejia Tian et al.
Aims: Resistant hypertension is associated with a high risk of cardiovascular disease, chronic kidney disease, and mortality. Yet, its management is challenging. This study aims to establish the comparative effectiveness ...
Meta-Analysis
Cardiovascular research. 2024 Feb 27;120(1):108-119. DOI:10.1093/cvr/cvad165 2024
Daniel Harding,Federica Marelli-Berg
Daniel Harding
Canonical Wnt pathway and the LDL receptor superfamily in neuronal cholesterol homeostasis and function [0.03%]
canonical Wnt信号通路和LDL受体超家族在神经元胆固醇稳态及功能中的作用
Maria Borrell-Pages,Aureli Luquero,Gemma Vilahur et al.
Maria Borrell-Pages et al.
Aims: There is little information on the regulation of cholesterol homeostasis in the brain. Whether cholesterol crosses the blood-brain barrier is under investigation, but the present understanding is that cholesterol me...