SARS-CoV-2 induced vascular endothelial dysfunction: direct or indirect effects? [0.03%]
SARS-CoV-2诱导的血管内皮功能障碍：直接或间接效应？
Kathy O Lui,Zhangjing Ma,Stefanie Dimmeler
Kathy O Lui
Clinical evidence reveals that manifestations of endothelial dysfunction are widely observed in COVID-19 and long-COVID patients. However, whether these detrimental effects are caused by direct infection of the endothelium or are indirectly...
Sphingosine-1-phosphate receptor 3 regulates the transendothelial transport of high-density lipoproteins and low-density lipoproteins in opposite ways [0.03%]
鞘氨醇-1-磷酸受体3以相反的方式调节高密度和低密度脂蛋白的内皮细胞转运功能
Srividya Velagapudi,Dongdong Wang,Francesco Poti et al.
Srividya Velagapudi et al.
Aims: The entry of lipoproteins from blood into the arterial wall is a rate-limiting step in atherosclerosis. It is controversial whether this happens by filtration or regulated transendothelial transport.Because sphingos...
Remodelling of cAMP dynamics within the SERCA2a microdomain in heart failure with preserved ejection fraction caused by obesity and type 2 diabetes [0.03%]
肥胖和2型糖尿病所致射血分数保留心力衰竭中SERCA2a微域内cAMP动力学的重塑
Ping Lai,Susanne S Hille,Hariharan Subramanian et al.
Ping Lai et al.
Aims: Despite massive efforts, we remain far behind in our attempts to identify effective therapies to treat heart failure with preserved ejection fraction (HFpEF). Diastolic function is critically regulated by sarcoplasm...
An inflammation resolution-promoting intervention prevents atrial fibrillation caused by left ventricular dysfunction [0.03%]
促进炎症消退的干预可预防左心室功能障碍引起的房颤
Roddy Hiram,Feng Xiong,Patrice Naud et al.
Roddy Hiram et al.
Aims: Recent studies suggest that bioactive mediators called resolvins promote an active resolution of inflammation. Inflammatory signalling is involved in the development of the substrate for atrial fibrillation (AF). Th...
Xiaojun Liu,Haobo Li,Margaret H Hastings et al.
Xiaojun Liu et al.
Aims: Physiological cardiac hypertrophy occurs in response to exercise and can protect against pathological stress. In contrast, pathological hypertrophy occurs in disease and often precedes heart failure. The cardiac pat...
Dysregulated iron homeostasis in dystrophin-deficient cardiomyocytes: correction by gene editing and pharmacological treatment [0.03%]
杜氏肌营养不良心肌细胞中铁稳态失调：由基因编辑和药物治疗进行纠正
Kalina Andrysiak,Gabriela Machaj,Dominik Priesmann et al.
Kalina Andrysiak et al.
Aims: Duchenne muscular dystrophy (DMD)-associated cardiomyopathy is a serious life-threatening complication, the mechanisms of which have not been fully established, and therefore no effective treatment is currently avai...
Daniel Harding,Silvia Fanti,Federica Marelli-Berg
Daniel Harding
Tim De Coster,Alexander S Teplenin,Iolanda Feola et al.
Tim De Coster et al.
Aims: Diseased atria are characterized by functional and structural heterogeneities, adding to abnormal impulse generation and propagation. These heterogeneities are thought to lie at the origin of fractionated electrogra...