Depleting inositol pyrophosphate 5-InsP7 protected the heart against ischaemia-reperfusion injury by elevating plasma adiponectin [0.03%]
消耗肌醇焦磷酸酯 5-InsP7通过提高血浆脂联素水平保护心脏免受缺血/再灌注损伤
Lin Fu,Jimin Du,David Furkert et al.
Lin Fu et al.
Aims: Adiponectin is an adipocyte-derived circulating protein that exerts cardiovascular and metabolic protection. Due to the futile degradation of endogenous adiponectin and the challenges of exogenous administration, re...
Cardiometabolic disease: linking pathogenic mechanisms to therapeutic opportunities [0.03%]
心脏代谢性疾病：从致病机制到治疗机会的链接
Triantafyllos Chavakis,Francesco Cosentino,Ann Marie Schmidt
Triantafyllos Chavakis
Vasostatins: new molecular targets for atherosclerosis, post-ischaemic angiogenesis, and arteriogenesis [0.03%]
血管静止因子：动脉粥样硬化、缺血后血管生成和动脉新生的新的分子靶点
Rosalinda Madonna,Serena Barachini,Sandra Ghelardoni et al.
Rosalinda Madonna et al.
The chromogranin-secretogranin secretory proteins-granins-are acidic proteins localized in granules of endocrine cells and neurons. The chromogranin family includes chromogranins A (CgA) and B, as well as secretogranin II (once called chrom...
Hypertrophic cardiomyopathy dysfunction mimicked in human engineered heart tissue and improved by sodium-glucose cotransporter 2 inhibitors [0.03%]
钠-葡萄糖共转运蛋白2抑制剂改善的人造心肌组织对肥厚型心肌病的仿效功能障碍
Paul J M Wijnker,Rafeeh Dinani,Nico C van der Laan et al.
Paul J M Wijnker et al.
Aims: Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiomyopathy, often caused by pathogenic sarcomere mutations. Early characteristics of HCM are diastolic dysfunction and hypercontractility. Treatment...
Histone demethylase KDM5 regulates cardiomyocyte maturation by promoting fatty acid oxidation, oxidative phosphorylation, and myofibrillar organization [0.03%]
组蛋白去甲基化酶KDM5通过促进脂肪酸氧化、氧化磷酸化和肌原纤维组织来调节心肌细胞成熟
Manisha Deogharia,Leslye Venegas-Zamora,Akanksha Agrawal et al.
Manisha Deogharia et al.
Aims: Human pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) provide a platform to identify and characterize factors that regulate the maturation of CMs. The transition from an immature foetal to an adult CM state ...
Perilipin 1: a systematic review on its functions on lipid metabolism and atherosclerosis in mice and humans [0.03%]
perilipin 1：系统回顾其在小鼠和人体内脂质代谢及动脉粥样硬化中的功能
Camille Desgrouas,Tabea Thalheim,Mathieu Cerino et al.
Camille Desgrouas et al.
The function of perilipin 1 in human metabolism was recently highlighted by the description of PLIN1 variants associated with various pathologies. These include severe familial partial lipodystrophy and early onset acute coronary syndrome. ...
Cardiac monoamine oxidase-A inhibition protects against catecholamine-induced ventricular arrhythmias via enhanced diastolic calcium control [0.03%]
心脏单胺氧化酶A的抑制通过增强舒张期钙控制来防止儿茶酚胺诱导的室性心律失常
Qian Shi,Hamza Malik,Rachel M Crawford et al.
Qian Shi et al.
Aims: A mechanistic link between depression and risk of arrhythmias could be attributed to altered catecholamine metabolism in the heart. Monoamine oxidase-A (MAO-A), a key enzyme involved in catecholamine metabolism and ...
Endothelium-specific SIRT7 targeting ameliorates pulmonary hypertension through Krüpple-like factor 4 deacetylation [0.03%]
通过Krüpple样因子4去乙酰化作用，特异性靶向内皮细胞SIRT7以改善肺动脉高压
Jin Zhang,Chenzhong Xu,Xiaolong Tang et al.
Jin Zhang et al.
Aims: Pulmonary hypertension (PH) is a pulmonary vascular disease characterized by a high mortality rate. Pulmonary arterial endothelium cells (PAECs) serve as a primary sensor of various environmental cues, such as shear...
Can cardiomyocytes bypass the 'Ca2+-induced Ca2+-release' mechanism? [0.03%]
心肌细胞能绕过“Ca2+-诱导的Ca2+释放”机制吗？
Shuai Luo,Jean-Pierre Benitah,Ana María Gómez
Shuai Luo
The proarrhythmogenic role of autonomics and emerging neuromodulation approaches to prevent sudden death in cardiac ion channelopathies [0.03%]
自主神经在致心律失常中的作用及预防心脏离子通道病突发死亡的新兴神经调节方法
Johanna B Tonko,Pier D Lambiase
Johanna B Tonko
Ventricular arrhythmias in cardiac channelopathies are linked to autonomic triggers, which are sub-optimally targeted in current management strategies. Improved molecular understanding of cardiac channelopathies and cellular autonomic signa...