Marginal zone B cells produce 'natural' atheroprotective IgM antibodies in a T cell-dependent manner [0.03%]
边缘区B细胞以T细胞依赖性方式产生“天然”的抗动脉粥样硬化IgM抗体
James Harrison,Stephen A Newland,Wei Jiang et al.
James Harrison et al.
Aims: The adaptive immune response plays an important role in atherosclerosis. In response to a high-fat/high-cholesterol (HF/HC) diet, marginal zone B (MZB) cells activate an atheroprotective programme by regulating the ...
LNK/SH2B3 loss of function increases susceptibility to murine and human atrial fibrillation [0.03%]
LNK/SH2B3缺失功能增加小鼠和人房颤的易感性
Matthew B Murphy,Zhenjiang Yang,Tuerdi Subati et al.
Matthew B Murphy et al.
Aims: The lymphocyte adaptor protein (LNK) is a negative regulator of cytokine and growth factor signalling. The rs3184504 variant in SH2B3 reduces LNK function and is linked to cardiovascular, inflammatory, and haematolo...
Latent drivers for atrial fibrillation and specific patterns of localized fibrosis [0.03%]
房颤及局部纤维化特定模式的潜在驱动因素
Albert J Rogers,Sanjiv M Narayan
Albert J Rogers
Effect of lipid-lowering therapies on C-reactive protein levels: a comprehensive meta-analysis of randomized controlled trials [0.03%]
调脂治疗对C反应蛋白水平的影响：随机临床试验的全面meta分析
Sining Xie,Federica Galimberti,Elena Olmastroni et al.
Sining Xie et al.
Chronic low-degree inflammation is a hallmark of atherosclerotic cardiovascular (CV) disease. To assess the effect of lipid-lowering therapies on C-reactive protein (CRP), a biomarker of inflammation, we conducted a meta-analysis according ...
Meta-Analysis
Cardiovascular research. 2024 Mar 30;120(4):333-344. DOI:10.1093/cvr/cvae034 2024
Restoration of blood vessel regeneration in the era of combination SGLT2i and GLP-1RA therapy for diabetes and obesity [0.03%]
糖尿病和肥胖组合使用SGLT2i和GLP-1RA治疗时代血管再生的恢复
Daniella C Terenzi,Ehab Bakbak,Hwee Teoh et al.
Daniella C Terenzi et al.
Ischaemic cardiovascular diseases, including peripheral and coronary artery disease, myocardial infarction, and stroke, remain major comorbidities for individuals with type 2 diabetes (T2D) and obesity. During cardiometabolic chronic diseas...
The role of endoplasmic reticulum-mitochondria-associated membranes in diabetic kidney disease [0.03%]
内质网-线粒体关联膜在糖尿病肾病中的作用
Ahmed Elwakiel,Akash Mathew,Berend Isermann
Ahmed Elwakiel
Diabetic kidney disease (DKD) is the leading cause of end-stage renal disease worldwide. The pathomechanisms of DKD are multifactorial, yet haemodynamic and metabolic changes in the early stages of the disease appear to predispose towards i...
Therapeutic targeting of cell transition: ready for clinical prime-time? [0.03%]
治疗性靶向细胞转变：临床应用时机成熟？
Emiel P C van der Vorst,Jason C Kovacic
Emiel P C van der Vorst
SERCA2a microdomain cAMP changes in heart failure with preserved ejection fraction [0.03%]
射血分数保留的心力衰竭中SERCA2a微域cAMP变化
Michael Gotthardt,Stephan E Lehnart
Michael Gotthardt
Sequestosome 1 (p62) mitigates hypoxia-induced cardiac dysfunction by stabilizing hypoxia-inducible factor 1α and nuclear factor erythroid 2-related factor 2 [0.03%]
封闭体1（p62）通过稳定缺氧诱导因子1α和核因子红系2相关因子2减轻缺氧引起的心脏功能障碍
Rajeshwary Ghosh,Amir Nima Fatahian,Omid M T Rouzbehani et al.
Rajeshwary Ghosh et al.
Aims: Heart failure due to ischaemic heart disease (IHD) is a leading cause of mortality worldwide. A major contributing factor to IHD-induced cardiac damage is hypoxia. Sequestosome 1 (p62) is a multi-functional adaptor ...
ISG15 blocks cardiac glycolysis and ensures sufficient mitochondrial energy production during Coxsackievirus B3 infection [0.03%]
ISG15在Coxsackievirus B3感染期间阻断心脏糖酵解并确保线粒体能量产生充足
Clara Bredow,Fabien Thery,Eva Katrin Wirth et al.
Clara Bredow et al.
Aims: Virus infection triggers inflammation and, may impose nutrient shortage to the heart. Supported by type I interferon (IFN) signalling, cardiomyocytes counteract infection by various effector processes, with the IFN-...