Transition to innovative, human-relevant pre-clinical cardiovascular research: a perspective [0.03%]
心血管研究向创新型、符合伦理的临床前研究转变：一种观点
Evangelos P Daskalopoulos,Pierre Deceuninck,Maurice Whelan et al.
Evangelos P Daskalopoulos et al.
Joshua A Keefe,Shuai Zhao,Xander H T Wehrens
Joshua A Keefe
FLT4 causes developmental disorders of the cardiovascular and lymphovascular systems via pleiotropic molecular mechanisms [0.03%]
FLT4通过多效性分子机制引起心血管系统和淋巴血管系统的发育障碍
Richard M Monaghan,Richard W Naylor,Daisy Flatman et al.
Richard M Monaghan et al.
Aims: Rare, deleterious genetic variants in FLT4 are associated with Tetralogy of Fallot (TOF), the most common cyanotic congenital heart disease (CHD). Distinct genetic variants in FLT4 are also an established cause of M...
Is cutting-edge imaging technology superior to conventional angiography in improving outcomes of coronary artery stenting? [0.03%]
高端影像技术在冠状动脉支架植入术中的应用是否优于常规血管造影？
Tomoyo Sugiyama,Ik-Kyung Jang
Tomoyo Sugiyama
miR-369-3p ameliorates diabetes-associated atherosclerosis by regulating macrophage succinate-GPR91 signaling [0.03%]
微小核糖核酸-369-3p通过调节巨噬细胞琥珀酸-GPR91信号通路改善糖尿病相关动脉粥样硬化
Shruti Rawal,Vinay Randhawa,Syed Husain Mustafa Rizvi et al.
Shruti Rawal et al.
Aims: Diabetes leads to dysregulated macrophage immunometabolism, contributing to accelerated atherosclerosis progression. Identifying critical factors to restore metabolic alterations and promote resolution of inflammati...
Low-intensity pulsed ultrasound protects from inflammatory dilated cardiomyopathy through inciting extracellular vesicles [0.03%]
低强度脉冲超声通过诱发外泌体抵抗心肌炎性损伤导致的心室扩大和心功能障碍
Ping Sun,Yi Li,Yifei Li et al.
Ping Sun et al.
Aims: CD4+ T cells are activated during inflammatory dilated cardiomyopathy (iDCM) development to induce immunogenic responses that damage the myocardium. Low-intensity pulsed ultrasound (LIPUS), a novel physiotherapy for...
Targeting macrophages with multifunctional nanoparticles to detect and prevent atherosclerotic cardiovascular disease [0.03%]
多功能纳米颗粒靶向巨噬细胞检测和预防动脉粥样硬化心血管病
Victoria Nankivell,Achini K Vidanapathirana,Ayla Hoogendoorn et al.
Victoria Nankivell et al.
Despite the emergence of novel diagnostic, pharmacological, interventional, and prevention strategies, atherosclerotic cardiovascular disease remains a significant cause of morbidity and mortality. Nanoparticle (NP)-based platforms encompas...
The ketogenic diet does not improve cardiac function and blunts glucose oxidation in ischemic heart failure [0.03%]
酮体饮食不能改善缺血性心力衰竭患者的心功能并抑制缺血心肌的糖酵解能力
Kim L Ho,Qutuba Karwi,Faqi Wang et al.
Kim L Ho et al.
Aims: Cardiac energy metabolism is perturbed in ischemic heart failure and is characterized by a shift from mitochondrial oxidative metabolism to glycolysis. Notably, the failing heart relies more on ketones for energy th...
Serine protease inhibitor, SerpinA3n, regulates cardiac remodelling after myocardial infarction [0.03%]
serpinA3n(丝氨酸蛋白酶抑制剂)调节心肌梗死后的心脏重塑作用
Qihao Sun,Wei Chen,Rimao Wu et al.
Qihao Sun et al.
Aims: Following myocardial infarction (MI), the heart repairs itself via a fibrotic repair response. The degree of fibrosis is determined by the balance between deposition of extracellular matrix (ECM) by activated fibrob...
Differential sex-dependent susceptibility to diastolic dysfunction and arrhythmia in cardiomyocytes from obese diabetic HFpEF model [0.03%]
肥胖糖尿病心脏重塑模型中性别差异依赖性心肌细胞舒张功能和心律失常的易感性研究
Juliana Mira Hernandez,Erin Y Shen,Christopher Y Ko et al.
Juliana Mira Hernandez et al.
Aim: Sex-differences in heart failure with preserved ejection fraction (HFpEF) are important, but key mechanisms involved are incompletely understood. While animal models can inform about sex-dependent cellular and molecu...