Activated factor X stimulates atrial endothelial cells and tissues to promote remodeling responses through AT1R/NADPH oxidases/SGLT1/2 [0.03%]
活化因子X通过AT1R/NADPH氧化酶/SGLT1/2刺激心房内皮细胞和组织以促进重塑反应
Walaa Fakih,Ali Mroueh,Dal-Seong Gong et al.
Walaa Fakih et al.
Aims: Atrial fibrillation (AF), the most common cardiac arrhythmia favoring ischemic stroke and heart failure involves left atrial remodeling, fibrosis and a complex interplay between cardiovascular risk factors. This stu...
Harnessing the potential of monocytes/macrophages to regenerate tissue-engineered vascular grafts [0.03%]
利用单核细胞/巨噬细胞的潜能再生组织工程血管移植物
Arundhati Das,Randall J Smith,Stelios T Andreadis
Arundhati Das
Cell-free tissue-engineered vascular grafts provide a promising alternative to treat cardiovascular disease, but timely endothelialization is essential for ensuring patency and proper functioning post-implantation. Recent studies from our l...
Inhibition of de novo ceramide synthesis by Sirtuin-1 improves beta-cell function and glucose metabolism in type 2 diabetes [0.03%]
Sirtuin-1抑制从头合成鞘氨醇脂类能改善2型糖尿病患者的胰岛素β细胞功能和糖代谢状况
Srividya Velagapudi,Gergely Karsai,Maria Karsai et al.
Srividya Velagapudi et al.
Background: Obesity and type 2 diabetes (T2D) are major risk factors for cardiovascular diseases (CVD). Dysregulated pro-apoptotic ceramide synthesis reduces β-cell insulin secretion, thereby promoting hyperglycemic stat...
Empagliflozin inhibits increased Na influx in atrial cardiomyocytes of patients with HFpEF [0.03%]
恩格列净可抑制射血分数保留型心力衰竭患者心房肌细胞内钠离子增多
M Trum,J Riechel,E Schollmeier et al.
M Trum et al.
Aims: Heart failure with preserved ejection fraction (HFpEF) causes substantial morbidity and mortality. Importantly, atrial remodeling and atrial fibrillation is frequently observed in HFpEF. Sodium-glucose cotransporter...
Role of endothelial Raptor in abnormal arteriogenesis after lower limb ischemia in type-2 diabetes [0.03%]
糖尿病患者下肢缺血后的异常动脉生成与内皮细胞Raptor的关系研究
Ting Liu,Jiachen Zhang,Fangyuan Chang et al.
Ting Liu et al.
Aims: Proper arteriogenesis after tissue ischemia is necessary to rebuild stable blood circulation; nevertheless, this process is impaired in type-2 diabetes mellitus (T2DM). Raptor, is a scaffold protein and a component ...
Virginie Montiel,Jean-Luc Balligand
Virginie Montiel
Adenosine kinase inhibition protects mice from abdominal aortic aneurysm via epigenetic modulation of VSMC inflammation [0.03%]
腺苷激酶抑制通过表观遗传调控血管平滑肌细胞炎症保护小鼠免受腹主动脉瘤的侵害
Jiean Xu,Zhiping Liu,Qiuhua Yang et al.
Jiean Xu et al.
Aim: Abdominal aortic aneurysm (AAA) is a common, serious vascular disease with no effective pharmacological treatment. The nucleoside adenosine plays an important role in modulating vascular homeostasis, which prompted u...
Inhibition of TBL1 cleavage alleviates doxorubicin-induced cardiomyocytes death by regulating the Wnt/β-catenin signal pathway [0.03%]
TBL1切割的抑制通过调节Wnt/β-连环蛋白信号通路缓解多柔比星诱导的心肌细胞死亡
Sun-Ho Lee,Jangho Lee,Jaewon Oh et al.
Sun-Ho Lee et al.
Aims: Doxorubicin (DOX) is a widely used anthracycline anticancer agent; however, its irreversible effects on the heart can result in DOX-induced cardiotoxicity (DICT) after cancer treatment. Unfortunately, the pathophysi...
Cardiac magnetic resonance or computed tomography: are we ready for a change of gold standard before transcatheter aortic valve replacement? [0.03%]
心脏磁共振还是心脏CT：经导管主动脉瓣置换术前会接受黄金标准的更改吗？
Danuta Sorysz,Marc Dweck
Danuta Sorysz
Oxidative DNA damage promotes vascular aging associated with changes in extracellular matrix-regulating proteins [0.03%]
氧化性DNA损伤通过改变细胞外基质调节蛋白促进血管衰老
Kirsty Foote,Marieke Rienks,Lukas Schmidt et al.
Kirsty Foote et al.
Aims: Vascular aging is characterized by vessel stiffening, with increased deposition of extracellular matrix (ECM) proteins including collagens. Oxidative DNA damage occurs in vascular aging, but how it regulates ECM pro...