Anniek Frederike Lubberding,Simon Veedfald,Jonathan Samuel Achter et al.
Anniek Frederike Lubberding et al.
Aims: Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are increasingly used to treat type 2 diabetes and obesity. Albeit cardiovascular outcomes generally improve, treatment with GLP-1 RAs is associated with increas...
Cardiomyocyte βII spectrin plays a critical role in maintaining cardiac function by regulating mitochondrial respiratory function [0.03%]
心肌细胞βII谱系蛋白通过调节线粒体呼吸功能维持心脏功能
Rongjin Yang,Banjun Ruan,Rutao Wang et al.
Rongjin Yang et al.
Aims: βII spectrin is a cytoskeletal protein known to be tightly linked to heart development and cardiovascular electrophysiology. However, the roles of βII spectrin in cardiac contractile function and pathological post...
Bhakti I Zakarauskas-Seth,Suphansa Sawamiphak
Bhakti I Zakarauskas-Seth
Association between cumulative uric acid exposure and the risk of incident cardiac conduction block [0.03%]
尿酸暴露与新发心脏传导阻滞风险的相关性研究
Na Li,Liufu Cui,Panagiotis Korantzopoulos et al.
Na Li et al.
Ryosuke Sato,Mirela Vatic,Guilherme Wesley Peixoto da Fonseca et al.
Ryosuke Sato et al.
In an ageing society, the importance of maintaining healthy life expectancy has been emphasized. As a result of age-related decline in functional reserve, frailty is a state of increased vulnerability and susceptibility to adverse health ou...
β1 integrins regulate cellular behavior and cardiomyocyte organization during ventricular wall formation [0.03%]
β1整合素在心室壁形成过程中调控细胞行为和心肌细胞组织化作用
Lianjie Miao,Yangyang Lu,Anika Nusrat et al.
Lianjie Miao et al.
Aims: The mechanisms regulating the cellular behavior and cardiomyocyte organization during ventricular wall morphogenesis are poorly understood. Cardiomyocytes are surrounded by extracellular matrix (ECM) and interact wi...
Phosphodiesterase-mediated modulation of subcellular cAMP levels to reduce heart failure [0.03%]
磷二酯酶介导的亚细胞cAMP水平调节可减少心力衰竭发生率
Maurizio Forte,Giacomo Frati,Sebastiano Sciarretta
Maurizio Forte
Gene therapy with phosphodiesterases 2A and 4B ameliorates heart failure and arrhythmias by improving subcellular cAMP compartmentation [0.03%]
磷二酯酶2A和4B的基因治疗通过改善细胞内环磷酸腺苷隔室化来缓解心力衰竭和心律失常
Nikoleta Pavlaki,Alexander Froese,Wener Li et al.
Nikoleta Pavlaki et al.
Aims: Gene therapy with cardiac phosphodiesterases (PDEs) such as PDE4B has recently been described to effectively prevent heart failure in mice. However, exact molecular mechanisms of its beneficial effects, apart from g...
Rahul S Gandhi,Betty Raman
Rahul S Gandhi
Inclisiran administration potently and durably lowers LDL-C over an extended-term follow-up: the ORION-8 trial [0.03%]
Inclisiran给药显著而持久地降低LDL-C：ORION-8延长随访研究
R Scott Wright,Frederick J Raal,Wolfgang Koenig et al.
R Scott Wright et al.
Background and aims: Data describing the long-term efficacy, safety, and tolerability of inclisiran are limited. This was explored in ORION-8, an open-label extension study of preceding Phase 2 and Phase 3 placebo-control...