Daily oral administration of probiotics engineered to constantly secrete short-chain fatty acids effectively prevents myocardial injury from subsequent ischemic heart disease [0.03%]
口服递送工程益生菌恒定分泌短链脂肪酸有效预防后续心脏缺血诱导的心肌损伤
Quynh Hoa Pham,Thi Van Anh Bui,Woo-Sup Sim et al.
Quynh Hoa Pham et al.
Aim: Given the extremely limited regeneration potential of the heart, one of the most effective strategies to reduce the prevalence and mortality of coronary artery disease is prevention. Short-chain fatty acids (SCFAs), ...
Central memory CD4+ T cells play a protective role against immune checkpoint inhibitor-associated myocarditis [0.03%]
中央记忆CD4+t细胞在免疫检查点抑制剂相关心肌炎中发挥保护作用
Jiajun Yu,Bo Long,Ziyong Li et al.
Jiajun Yu et al.
Aims: The widespread use of immune checkpoint inhibitors (ICIs) has demonstrated significant survival benefits for cancer patients and also carry the risk of immune-related adverse events (irAEs). ICIs-associated myocardi...
Novel thrombolytic treatments of acute ischemic stroke, choosing the right safety belt to drive this car [0.03%]
急性缺血性卒中的新型溶栓疗法——选择正确的安全带驾驶这辆车
Heleen van Beusekom,Meiqi Wang,Diederik Dippel
Heleen van Beusekom
Macrophage-derived FGFR1 drives atherosclerosis through PLCγ-mediated activation of NF-κB inflammatory signaling pathway [0.03%]
巨噬细胞来源的FGFR1通过PLCγ介导的NF-κB炎症信号通路促进动脉粥样硬化形成
Lintao Wang,Wu Luo,Suya Zhang et al.
Lintao Wang et al.
Background: Atherosclerosis is a leading cause of cardiovascular morbidity and mortality. Atherosclerotic lesions show increased levels of proteins associated with the fibroblast growth factor receptor (FGFR) pathway. How...
The ketogenic diet is unable to improve cardiac function in ischemic heart failure: an unexpected result? [0.03%]
生酮饮食无法改善缺血性心力衰竭患者的心脏功能：一个意外的结果？
Carolina Magdalen Greco,Enzo Nisoli
Carolina Magdalen Greco
Myeloid cannabinoid CB1 receptor deletion confers atheroprotection in male mice by reducing macrophage proliferation in a sex-dependent manner [0.03%]
雄性小鼠髓系大麻素CB1受体缺失通过减少巨噬细胞增殖而依赖性别地赋予抗动脉粥样硬化作用
Yong Wang,Guo Li,Bingni Chen et al.
Yong Wang et al.
Aims: Although the cannabinoid CB1 receptor has been implicated in atherosclerosis, its cell-specific effects in this disease are not well understood. To address this, we generated a transgenic mouse model to study the ro...
Transient stabilization of human cardiovascular progenitor cells from hPSCs in vitro reflects stage-specific heart development in vivo [0.03%]
人多能干细胞体外分化心血管祖细胞的过渡稳定状态反映体内心脏发育不同阶段的特征
Bolesani Emiliano,Bornhorst Dorothee,Lavanya M Iyer et al.
Bolesani Emiliano et al.
Aim: Understanding the molecular identity of human pluripotent stem cell (hPSC)-derived cardiac progenitors and mechanisms controlling their proliferation and differentiation, is valuable for developmental biology and reg...
Single-cell RNA sequencing identifies IFNICs as a cellular target for mitigating the progression of abdominal aortic aneurysm and rupture risk [0.03%]
单细胞RNA测序鉴定出IFNIC细胞是防治腹主动脉瘤进展和破裂风险的靶细胞
Sheng Le,Jia Wu,Hao Liu et al.
Sheng Le et al.
Aims: Abdominal aortic aneurysm (AAA) represents a life-threatening condition characterized by medial layer degeneration of the abdominal aorta. Nevertheless, knowledge regarding changes in regulators associated with aort...
Joshua Elliott,Barbara Bodinier,Matthew Whitaker et al.
Joshua Elliott et al.
Aims: Evaluate sex differences in cardiovascular disease (CVD) risk prediction, including use of i) optimal sex-specific risk predictors and ii) sex-specific risk thresholds. ...
A suite of genome-engineered hepatic cells provide novel insights into the spatiotemporal metabolism of APOB and APOB-containing lipoprotein secretion [0.03%]
一套基因工程肝细胞工具揭示了APOB及其含APOB脂蛋白的时空代谢规律
Amber Meurs,Klevis Ndoj,Marlene van den Berg et al.
Amber Meurs et al.
Aims: APOB-containing very-low-density lipoprotein (VLDL) production, secretion, and clearance by hepatocytes is a central determinant of hepatic and circulating lipid levels. Impairment of any of the aforementioned proce...