Margaret H Hastings,Qiulian Zhou,Chao Wu et al.
Margaret H Hastings et al.
Cardiac aging is an intricate and multifaceted process with considerable impact on public health, especially given the global demographic shift towards aged populations. This review discusses structural, cellular and functional changes asso...
Forward programming of hiPSCs via the transcription factor ETV2: rapid, reproducible, and cost-effective generation of highly enriched, functional endothelial cells [0.03%]
利用转录因子ETV2向前编程hiPSCs：高效生成丰富且功能齐全的内皮细胞
Sarah Rieck,Kritika Sharma,Carlotta Altringer et al.
Sarah Rieck et al.
Aims: Endothelial cell (EC) dysfunction plays a key role in the initiation and progression of cardiovascular disease. However, studying these disorders in ECs from patients is challenging, hence the use of human induced p...
Intraplatelet miRNA-126 regulates thrombosis and its reduction contributes to platelet inhibition [0.03%]
血小板内miRNA-126调控血栓形成及其降低有助于抑制血小板功能
Lu-Jun Zhang,Yang-Xi Hu,Rong-Zhong Huang et al.
Lu-Jun Zhang et al.
Aims: MicroRNA-126 (miR-126), one of the most abundant microRNAs in platelets, is involved in the regulation of platelet activity and the circulating miR-126 is reduced during antiplatelet therapy. However, whether intrap...
Embryonic alcohol exposure in zebrafish predisposes adults to cardiomyopathy and diastolic dysfunction [0.03%]
胚胎酒精暴露使斑马鱼成年后易患心肌病和舒张功能障碍
Olivia Weeks,Xinlei Gao,Sandeep Basu et al.
Olivia Weeks et al.
Aims: Fetal alcohol spectrum disorders (FASDs) impact up to 0.8% of the global population. However, cardiovascular health outcomes in adult patients, along with predictive biomarkers for cardiac risk stratification, remai...
James W S Jahng,Joseph C Wu
James W S Jahng
Novel formylpeptide receptor 1/2 agonist limits hypertension-induced cardiovascular damage [0.03%]
新型甲酰肽受体1/2激动剂限制高血压引起的血管损伤
Jaideep Singh,Kristy L Jackson,Haoyun Fang et al.
Jaideep Singh et al.
Aims: Formylpeptide receptors (FPRs) play a critical role in the regulation of inflammation, an important driver of hypertension-induced end-organ damage. We have previously reported that the biased FPR small-molecule ago...
SCUBE2 regulates adherens junction dynamics and vascular barrier function during inflammation [0.03%]
SCUBE2在炎症过程中调节粘附连接动力学和血管屏障功能
Yuh-Charn Lin,Ya-Jen Chang,Shiang-Shin Gau et al.
Yuh-Charn Lin et al.
Aims: SCUBE2 (Signal peptide-CUB-epidermal growth factor-like domain-containing protein 2) is a secreted or membrane-bound protein originally identified from endothelial cells (ECs). Our previous work showed that SCUBE2 f...
How far are we from accurate sex-specific risk prediction of cardiovascular disease? One size may not fit all [0.03%]
心血管疾病精确的性别特异风险预测还有多远？或许男女有别
Bi Huang,Mayank Dalakoti,Gregory Y H Lip
Bi Huang
Loss of Cavin-2 destabilizes PTEN and enhances Akt signaling pathway in cardiomyocytes [0.03%]
Cavin-2丢失使PTEN不稳定并增强心肌细胞中的Akt信号通路
Naoki Maruyama,Takehiro Ogata,Takeru Kasahara et al.
Naoki Maruyama et al.
Aims: Specific cavins and caveolins, known as caveolae-related proteins, have been implicated in cardiac hypertrophy and myocardial injury. Cavin-2 forms complexes with other caveolae-related proteins, but the role of Cav...