Coronavirus disease 2019-related myocardial injury is associated with immune dysregulation in symptomatic patients with cardiac magnetic resonance imaging abnormalities [0.03%]
冠状病毒病2019相关的心肌损伤与有心脏磁共振成像异常的患者的免疫失调有关
Andrej Ćorović,Xiaohui Zhao,Yuan Huang et al.
Andrej Ćorović et al.
Aims: While acute cardiovascular complications of coronavirus disease 2019 (COVID-19) are well described, less is known about longer-term cardiac sequelae. For many individuals with cardiac signs or symptoms arising after...
Observational Study
Cardiovascular research. 2024 Nov 25;120(14):1752-1767. DOI:10.1093/cvr/cvae159 2024
GWAS breakthroughs: mapping the journey from one locus to 393 significant coronary artery disease associations [0.03%]
基因组关联研究新突破：从一个位点到393个冠状动脉疾病显著相关位点的探索之旅
Rédouane Aherrahrou,Tobias Reinberger,Satwat Hashmi et al.
Rédouane Aherrahrou et al.
Coronary artery disease (CAD) poses a substantial threat to global health, leading to significant morbidity and mortality worldwide. It has a significant genetic component that has been studied through genome-wide association studies (GWAS)...
Inhibition of endothelial-to-mesenchymal transition in a large animal preclinical arteriovenous fistula model leads to improved remodelling and reduced stenosis [0.03%]
在大型动物前临床动静脉内瘘模型中抑制血管内皮细胞向间充质细胞转化可改善重塑并减少狭窄发生率
Yang Xu,Adam Korayem,Ana S Cruz-Solbes et al.
Yang Xu et al.
Aims: Vein grafts are used for many indications, including bypass graft surgery and arteriovenous fistula (AVF) formation. However, patency following vein grafting or AVF formation is suboptimal for various reasons, inclu...
Crucial role for sensory nerves and Na/H exchanger inhibition in dapagliflozin- and empagliflozin-induced arterial relaxation [0.03%]
感觉神经和Na / H交换子抑制在达格列净和恩格列净诱导的动脉松弛中的重要作用
Elizabeth A Forrester,Miguel Benítez-Angeles,Kaitlyn E Redford et al.
Elizabeth A Forrester et al.
Aims: Sodium/glucose transporter 2 (SGLT2 or SLC5A2) inhibitors lower blood glucose and are also approved treatments for heart failure independent of raised glucose. Various studies have showed that SGLT2 inhibitors relax...
Cross-species single-cell RNA sequencing reveals divergent phenotypes and activation states of adaptive immunity in human carotid and experimental murine atherosclerosis [0.03%]
跨物种单细胞RNA测序揭示人类颈动脉和实验性小鼠动脉粥样硬化适应性免疫的表型和激活状态的区别
Hauke Horstmann,Nathaly Anto Michel,Xia Sheng et al.
Hauke Horstmann et al.
Aims: The distinct functions of immune cells in atherosclerosis have been mostly defined by pre-clinical mouse studies. Contrastingly, the immune cell composition of human atherosclerotic plaques and their contribution to...
Comparative Study
Cardiovascular research. 2024 Nov 25;120(14):1713-1726. DOI:10.1093/cvr/cvae154 2024
New insights into the effects of glucagon-like peptide-1 on heart rate and sinoatrial node function [0.03%]
GLP-1对心率及窦房结功能作用的新认识
Simrandeep Kaur,Robert A Rose
Simrandeep Kaur
CircARCN1 aggravates atherosclerosis by regulating HuR-mediated USP31 mRNA in macrophages [0.03%]
Circular RNA CircARCN1 通过调节巨噬细胞中HuR介导的USP31 mRNA表达来加重动脉粥样硬化
Zhicheng Pan,Jialan Lv,Liding Zhao et al.
Zhicheng Pan et al.
Aims: Circular RNAs (circRNAs) are considered important regulators of biological processes, but their impact on atherosclerosis development, a key factor in coronary artery disease (CAD), has not been fully elucidated. We...
The European Society of Cardiology Working Group on Coronary Pathophysiology and Microcirculation [0.03%]
欧洲心脏病学会冠状动脉病理生理和微循环工作组
Edina Cenko,Marija Zdravkovic,Dimitris Tousoulis et al.
Edina Cenko et al.
Emerging opportunities to target inflammation: myocardial infarction and type 2 diabetes [0.03%]
针对炎症的治疗新机遇：心肌梗死和2型糖尿病
Tafadzwa T J Kufazvinei,Jason Chai,Katherine A Boden et al.
Tafadzwa T J Kufazvinei et al.
After myocardial infarction (MI), patients with type 2 diabetes have an increased rate of adverse outcomes, compared to patients without. Diabetes confers a 1.5-2-fold increase in early mortality and, importantly, this discrepancy has been ...