Air quality and health implications of exposure to ultrafine particle pollution [0.03%]
暴露于超细颗粒物污染下的空气质量及健康影响
Jos Lelieveld,Pantelis Georgiades,Matthias Kohl et al.
Jos Lelieveld et al.
Aims: Ultrafine particles (UFPs) smaller than 100 nm are ubiquitous in polluted air. Although they carry little mass, UFPs have a large exposure surface area, can bypass respiratory defences, translocate into the brain an...
Long noncoding RNA CARDINAL cis-activates MYOCD expression by recruiting histone reader ZZZ3 in vascular smooth muscle cell phenotype alteration [0.03%]
长非编码RNA CARDINAL通过招募组蛋白阅读蛋白ZZZ3调节成肌细胞表型转化中MYOCD的转录激活功能
Huimin Zhou,Shaozhao Zhang,Xingfeng Xu et al.
Huimin Zhou et al.
Aims: The phenotype alteration of vascular smooth muscle cells (VSMCs) is critical for vascular physiology and pathology. Transcription factors (TFs) and long non-coding RNAs (lncRNAs) play pivotal roles in the gene regul...
YAP plays a critical role in myocardial recovery from myocarditis by suppressing IFN-γ signaling pathway [0.03%]
YAP通过抑制IFN-γ信号途径在心肌炎诱导的心肌损伤修复中的关键作用
Yusuke Kametani,Masanori Obana,Ayaka Umeda et al.
Yusuke Kametani et al.
Aims: Despite the limited resilience of adult mammalian hearts, the heart damaged by inflammation naturally heals in a majority of patients with myocarditis. Therefore, therapeutic activation of intrinsic healing capacity...
Metabolic crisis and TRPM4 activation cause QT prolongation in TANGO2 deficiency disorder [0.03%]
TANGO2缺陷症中代谢危象和TRPM4激活导致QT间期延长
Lili Wang,Kyungsoo Kim,Prince J Kannankeril et al.
Lili Wang et al.
Aims: TANGO2 deficiency disorder (TDD), caused by homozygous large deletions in TANGO2, is associated with impaired fatty acid oxidation and metabolic crises that frequently trigger QT prolongation and arrhythmias. The ob...
Personalizing Atrial Fibrillation Therapy: Moving from Genetic Association to Mechanistic Translation [0.03%]
从遗传关联到机制转化的个性化房颤治疗
Matthew J Read,Camila Roman,Xander H T Wehrens
Matthew J Read
Placental Growth Factor Promotes Endothelial Activation and Inflammatory Remodelling in Pulmonary Hypertension [0.03%]
胎盘生长因子通过促进肺动脉内皮激活和炎症重塑来加重肺高血压病情
My Ngoc Ha,Raphaël Thuillet,Mina Ottaviani et al.
My Ngoc Ha et al.
Aims: Pulmonary arterial hypertension (PAH) is a progressive cardiopulmonary disorder marked by pulmonary vascular remodelling and vessel loss, paradoxically occurring despite high VEGF signaling. While VEGF/VEGFR pathway...
Endothelial-to-mesenchymal transition (EndMT) in atherosclerosis: mechanisms, models and therapies [0.03%]
动脉粥样硬化中的内皮细胞向间充质细胞转化（EndMT）：机制、模型和治疗方法
Iqra Ilyas,Paul C Evans,Bradford C Berk et al.
Iqra Ilyas et al.
Endothelial-to-mesenchymal transition (EndMT) has emerged as a key contributor to the development and progression of atherosclerotic cardiovascular disease. Driven by biomechanical, inflammatory, and metabolic cues within the vascular micro...
Nicole S L Chan,Courtney Cross,Joanne Bowen et al.
Nicole S L Chan et al.
As cancer survival rates improve, the long-term burden of treatment has become increasingly evident. Cancer survivors face a markedly higher risk of cardiovascular-related complications and premature, non-cancer-related mortality. In partic...
Lanyue Zhang,Murad Omarov,LingLing Xu et al.
Lanyue Zhang et al.
Aims: Atherosclerosis is currently evaluated by imaging, but scalable circulating biomarkers to detect its presence and quantify overall burden are lacking. We sought to define plasma proteomic signatures that reflect the...