Slack K+ channels confer protection against myocardial ischemia/reperfusion injury [0.03%]
SK+通道在心肌缺血/再灌注损伤中的保护作用
Anna Roslan,Katharina Paulus,Jiaqi Yang et al.
Anna Roslan et al.
Aims: Na+-activated Slack potassium (K+) channels are increasingly recognized as regulators of neuronal activity, yet little is known about their role in the cardiovascular system. Slack activity increases when intracellu...
Calciprotein particle counts associate with vascular remodelling in chronic kidney disease [0.03%]
钙蛋白颗粒计数与慢性肾脏疾病血管重塑相关性研究
Lian Feenstra,Melanie Reijrink,Andreas Pasch et al.
Lian Feenstra et al.
Aims: Calciprotein particles (CPPs) are circulating calcium and phosphate nanoparticles associated with the development of vascular calcification (VC) in chronic kidney disease (CKD). Although recent studies have been foc...
Neuroimmune circuits in the plaque and bone marrow regulate atherosclerosis [0.03%]
斑块和骨髓中的神经免疫回路调节动脉粥样硬化的发展
Teresa Gerhardt,Pacific Huynh,Cameron S McAlpine
Teresa Gerhardt
Atherosclerosis remains the leading cause of death globally. Although its focal pathology is atheroma that develops in arterial walls, atherosclerosis is a systemic disease involving contributions by many organs and tissues. It is now estab...
Zonation and ligand and dose dependence of sphingosine 1-phosphate receptor-1 signalling in blood and lymphatic vasculature [0.03%]
鞘氨醇-1-磷酸受体1在血液和淋巴管中的区室化及配体和剂量依赖性信号转导
Ilaria Del Gaudio,Anja Nitzsche,Kevin Boyé et al.
Ilaria Del Gaudio et al.
Aims: Circulating levels of sphingosine 1-phosphate (S1P), an HDL-associated ligand for the endothelial cell (EC) protective S1P receptor-1 (S1PR1), are reduced in disease states associated with endothelial dysfunction. Y...
Imaging the cerebral vasculature at different scales: translational tools to investigate the neurovascular interfaces [0.03%]
多尺度脑血管成像：探究神经血管界面的转化工具
L Carnevale,G Lembo
L Carnevale
The improvements in imaging technology opened up the possibility to investigate the structure and function of cerebral vasculature and the neurovascular unit with unprecedented precision and gaining deep insights not only on the morphology ...
ORION-8: one step closer to understanding the safety and efficacy of inclisiran [0.03%]
ORION-8：了解inclisiran安全性和有效性的一步
Lale Tokgözoğlu,Giuseppe Danilo Norata
Lale Tokgözoğlu
CircCHSY1 protects hearts against ischaemia/reperfusion injury by enhancing heme oxygenase 1 expression via miR-24-3p [0.03%]
环状RNA CircCHSY1通过增强miR-24-3p介导的血红素氧合酶1表达保护心脏免受缺血/再灌注损伤的影响
Jiliang Tan,Jie Min,Yun Jiang et al.
Jiliang Tan et al.
Aims: Circular RNAs (circRNAs) are important players involved in a variety of physiological and pathological processes. However, their functions and mechanisms during myocardial ischaemic injury and protection remain larg...
Histone deacetylase 6 suppression protects from myocardial ischaemia-reperfusion injury in diabetes: insights from genetic deletion and pharmacological inhibition [0.03%]
组蛋白去乙酰化酶6抑制保护糖尿病心肌缺血再灌注损伤：基因缺失和药理学抑制的启示
Yu-Jen Wang,Christian M Matter
Yu-Jen Wang
Can β-blockers prevent intracranial aneurysm rupture? - insights from Computational Fluid Dynamics analysis [0.03%]
计算流体动力学分析：β受体阻滞剂能预防颅内动脉瘤破裂吗？
Kornelia M Kliś,Roger M Krzyżewski,Borys M Kwinta et al.
Kornelia M Kliś et al.
Aim: Hypertension is a risk factor for intracranial aneurysm rupture. We analyzed whether the intake of drugs from specific classes of anti-hypertensive medications affects hemodynamic parameters of intracranial aneurysm ...
Pericytes in the brain and heart: functional roles and response to ischemia and reperfusion [0.03%]
脑和心肌周细胞的功能作用及缺血再灌注反应
Turgay Dalkara,Leif Østergaard,Gerd Heusch et al.
Turgay Dalkara et al.
In the last 20 years there has been a revolution in our understanding of how blood flow is regulated in many tissues. Whereas it used to be thought that essentially all blood flow control occurred at the arteriole level, it is now recognise...