Heart brain axis in health and disease: role of innate and adaptive immunity [0.03%]
健康与疾病状态下的心脑轴:先天免疫和适应性免疫的作用
Alba Simats,Hendrik Sager,Arthur Liesz
Alba Simats
The importance of the brain-heart interaction has been increasingly recognized as a critical physiological axis that is altered in disease. In this review, we explore the intricate relationship between the central nervous system and cardiov...
Trajectories of cardiovascular ageing - from molecular mechanisms to clinical implementation [0.03%]
心血管老化的轨迹-从分子机制到临床应用
Stefano Ministrini,Florian A Wenzl,Thomas F Lüscher et al.
Stefano Ministrini et al.
Due to its peculiar structure and function, the cardiovascular system is particularly vulnerable to the detrimental effects of ageing. Current knowledge about the molecular mechanisms of ageing revealed the processes actively promoting agei...
A reporter system for live cell tracking of human cardiomyocyte proliferation [0.03%]
人心脏细胞增殖的活体细胞追踪报道系统
Alessia Costa,Hannah Jill Hunkler,Shambhabi Chatterjee et al.
Alessia Costa et al.
Graphical Abstract
Mahmoud Abdellatif,Sophie T Schmid,Alexander Fuerlinger et al.
Mahmoud Abdellatif et al.
As the global demographic landscape continues to shift towards an aged population, so does the medical and socioeconomic burden of cardiovascular diseases. Indeed, ageing is one of, if not the, key risk factor for the development of cardiov...
Smooth muscle-specific deletion of cellular communication network factor 2 causes severe aorta malformation and atherosclerosis [0.03%]
平滑肌特异性删除细胞通讯网络因子2导致严重的主动脉畸形和动脉粥样硬化
Jannik H Larsen,Julie S Hegelund,Matilde K Pedersen et al.
Jannik H Larsen et al.
Aims: Cellular communication network factor 2 (CCN2) is a matricellular protein implicated in fibrotic diseases, with ongoing clinical trials evaluating anti-CCN2-based therapies. By uncovering CCN2 as abundantly expresse...
Corrigendum to: Transient stabilization of human cardiovascular progenitor cells from human pluripotent stem cells in vitro reflects stage-specific heart development in vivo [0.03%]
人多能干细胞体外分化心血管祖细胞的过渡稳定性反映了体内心脏发育不同阶段的特征的勘误函
Published Erratum
Cardiovascular research. 2024 Dec 4;120(15):1985. DOI:10.1093/cvr/cvae172 2024
Intravenous infusions of mesenchymal stromal cells have cumulative beneficial effects in a porcine model of chronic ischaemic cardiomyopathy [0.03%]
间充质基质细胞的静脉输注在慢性缺血性心肌病猪模型中产生累积的有益作用
Xian-Liang Tang,Marcin Wysoczynski,Anna M Gumpert et al.
Xian-Liang Tang et al.
Aims: The development of cell therapy as a widely available clinical option for ischaemic cardiomyopathy is hindered by the invasive nature of current cell delivery methods. Furthermore, the rapid disappearance of cells a...
Jasmeet S Reyat,Laura C Sommerfeld,Molly OReilly et al.
Jasmeet S Reyat et al.
Aims: Reduced left atrial PITX2 is associated with atrial cardiomyopathy and atrial fibrillation (AF). PITX2 is restricted to left atrial cardiomyocytes (aCMs) in the adult heart. The links between PITX2 deficiency, atria...
Sudden Unexpected Death in Epilepsy: Respiratory vs. Cardiac Contributions [0.03%]
癫痫猝死的呼吸因素和心脏因素贡献:突然意外死亡
Susan Lin,Theodore H Schwartz,Geoffrey S Pitt
Susan Lin
Sudden Unexpected Death in Epilepsy (SUDEP) poses a significant risk to life expectancy for individuals with epilepsy. Mechanistic insight, while incomplete, has advanced through clinical observational studies and animal models. Yet we lack...
Nuclear factor of activated T-cells 5 is indispensable for a balanced adaptive transcriptional response of lung endothelial cells to hypoxia [0.03%]
活化T细胞核因子5对肺内皮细胞缺氧适应性转录反应平衡至关重要
Hebatullah Laban,Sophia Siegmund,Katharina Schlereth et al.
Hebatullah Laban et al.
Aims: Chronic hypoxia causes detrimental structural alterations in the lung, which may cause pulmonary hypertension and are partially mediated by the endothelium. While its relevance for the development of hypoxia-associa...