Abnormal circadian rhythms exacerbate dilated cardiomyopathy by reducing the ventricular mechanical strength [0.03%]
异常的昼夜节律通过降低心室机械强度加重扩张型心肌病
Hao Jia,Hao Cui,Zijie Zhao et al.
Hao Jia et al.
Aims: Dilated cardiomyopathy (DCM) has etiological and pathophysiological heterogeneity. Abnormal circadian rhythm (ACR) is related to the development of DCM in animal models, but exploration based on clinical samples is ...
Olfr2+ macrophages: monocyte-derived, pro-inflammatory foamy-like cells in atherosclerosis [0.03%]
嗅觉受体Olfr2阳性巨噬细胞:动脉粥样硬化中的单核细胞来源的促炎泡沫状细胞
Clément Cochain,Alma Zernecke
Clément Cochain
Cardiac automaticity is modulated by IKACh in sinoatrial node during pregnancy [0.03%]
ICAH通道在窦房结中的作用:妊娠对心脏起搏细胞自律性的影响
Valérie Long,Gracia El Gebeily,Élisabeth Leblanc et al.
Valérie Long et al.
Aims: Pregnant women have a significantly elevated resting heart rate (HR), which makes cardiac arrhythmias more likely to occur. Although electrical remodeling of the sinoatrial node (SAN) has been documented, the underl...
Liver-targeted Angptl4 silencing by antisense oligonucleotide treatment attenuates hyperlipidemia and atherosclerosis development in APOE*3-Leiden.CETP mice [0.03%]
反义寡核苷酸介导的肝脏靶向Angptl4基因沉默对APOE*3-Leiden.CETP小鼠高脂血症和动脉粥样硬化的影响
Melanie Modder,Wietse In Het Panhuis,Mohan Li et al.
Melanie Modder et al.
Background and aims: Angiopoietin-like 3 (ANGPTL3) and 4 (ANGPTL4) inhibit lipoprotein lipase to regulate tissue fatty acid uptake from triglyceride-rich lipoproteins such as VLDL. While pharmacological inhibition of ANGP...
Endothelial oestrogen-myocardial cyclic guanosine monophosphate axis critically determines angiogenesis and cardiac performance during pressure overload [0.03%]
雌激素-心肌环磷酸鸟苷轴在压力超负荷下调控血管生成和心脏功能中发挥关键作用
Nobuaki Fukuma,Hiroyuki Tokiwa,Genri Numata et al.
Nobuaki Fukuma et al.
Aims: Oestrogen exerts beneficial cardiovascular effects by binding to specific receptors on various cells to activate nuclear and non-nuclear actions. Oestrogen receptor α (ERα) non-nuclear signalling confers protectio...
When bigger is better: utilizing large animal models in vein graft surgery to gain insights into endothelial-to-mesenchymal transition [0.03%]
更大更好:利用大型动物模型在静脉移植手术中获得内皮细胞向间充质细胞转化的见解
Clarissa Becher,Marie-José Goumans,Gonzalo Sanchez-Duffhues
Clarissa Becher
Uncovering vascular signature of sphingosine-1-phosphate receptor 1 activation [0.03%]
鞘氨醇-1-磷酸受体1活化的血管特征分析
Ewelina Józefczuk,Mateusz Siedlinski
Ewelina Józefczuk
Zinc-alpha2-glycoprotein modulates blood pressure by regulating renal lipid metabolism reprogramming-mediated urinary Na+ excretion in hypertension [0.03%]
锌-α₂-甘露糖蛋白通过调节肾脂质代谢重构介导的尿钠排泄调控高血压患者的血压
Xiaoxin Zhou,Chunyan Deng,Lin Chen et al.
Xiaoxin Zhou et al.
Aims: Organs modulating blood pressure are associated with a common cytokine known as adipokines. We chose Zinc-alpha2-glycoprotein (ZAG) due to its prioritized transcriptional level in the database. Previous studies show...
Maternal folic acid over-supplementation impairs cardiac function in mice offspring by inhibiting SOD1 expression [0.03%]
叶酸过补通过抑制SOD1表达损害小鼠后代心脏功能
Ke Cai,Feng Wang,Hai-Qun Shi et al.
Ke Cai et al.
Aims: Folic acid (FA) supplementation during pregnancy aims to protect foetal development. However, maternal over-supplementation of FA has been demonstrated to cause metabolic dysfunction and increase the risk of autism,...
Smad1/5 is acetylated in the dorsal aortae of the mouse embryo before the onset of blood flow, driving early arterial gene expression [0.03%]
胎盘中SMAD1/5在血流出现之前就在胚胎主动脉中发生乙酰化,从而驱动早期动脉基因的表达
Margo Daems,Ljuba C Ponomarev,Rita Simoes-Faria et al.
Margo Daems et al.
Aims: During embryonic development, arteriovenous (AV) differentiation ensures proper blood vessel formation and maturation. Defects in arterial or venous identity cause inappropriate fusion of vessels, resulting in atypi...