Renal denervation achieves its antiarrhythmic effect through attenuating macrophage activation and neuroinflammation in stellate ganglia in chronic heart failure [0.03%]
肾去神经通过减轻慢性心力衰竭星状神经节中巨噬细胞活化和神经炎症来发挥其抗心律失常作用
Wenfeng Hu,Huiyin Tu,Michael C Wadman et al.
Wenfeng Hu et al.
Aims: Renal denervation (RDN) is widely investigated in multiple studies of sympathetically driven cardiovascular diseases. While the therapeutic potential of RDN for ventricular arrhythmia has been reported, the mechanis...
GDF15 antagonism limits severe heart failure and prevents cardiac cachexia [0.03%]
GDF15抗性限制重度心力衰竭并预防心脏病恶病质现象
Minoru Takaoka,John A Tadross,Ali B A K Al-Hadithi et al.
Minoru Takaoka et al.
Aims: Heart failure and associated cachexia is an unresolved and important problem. This study aimed to determine the factors that contribute to cardiac cachexia in a new model of heart failure in mice that lack the integ...
A non-genetic model of vascular shunts informs on the cellular mechanisms of formation and resolution of arteriovenous malformations [0.03%]
一个非遗传性的血管吻合模型阐释动静脉畸形的形成和消退的细胞机制
Marie Ouarné,Andreia Pena,Daniela Ramalho et al.
Marie Ouarné et al.
Aims: Arteriovenous malformations (AVMs), a disorder characterized by direct shunts between arteries and veins, are associated with genetic mutations. However, the mechanisms leading to AV shunt formation and how shunts c...
Hypoxia-responsive zinc finger E-box-binding homeobox 2 (ZEB2) regulates a network of calcium-handling genes in the injured heart [0.03%]
缺氧响应锌指E盒结合同源框2(ZEB2)调节损伤心脏钙处理基因网络
Monika M Gladka,Arwa Kohela,Anne E de Leeuw et al.
Monika M Gladka et al.
Aims: Intracellular calcium (Ca2+) overload is known to play a critical role in the development of cardiac dysfunction. Despite the remarkable improvement in managing the progression of heart disease, developing effective...
Spatiotemporal EP4-fibulin-1 expression is associated with vascular intimal hyperplasia [0.03%]
EP4-fibulin-1时空表达与血管内膜增生的关系研究
Shigekuni Okumura,Sayuki Oka,Takako Sasaki et al.
Shigekuni Okumura et al.
Aims: Cyclooxygenase-2-derived prostaglandin E2 (PGE2) is thought to promote vascular intimal hyperplasia (IH). It has been reported that the PGE2 receptor EP4 is upregulated in injured vessels, and that EP4 signaling in ...
Double-stranded DNA enhances platelet activation, thrombosis, and myocardial injury via cyclic GMP-AMP synthase [0.03%]
双链DNA通过环状GMP-AMP合酶促进血小板活化、血栓形成和心肌损伤
Wei Zhang,Yan Zhang,Liping Han et al.
Wei Zhang et al.
Aims: Elevated dsDNA levels in STEMI patients are associated with increased infarct size and worse clinical outcomes. However, the direct effect of dsDNA on platelet activation remains unclear. This study aims to investig...
Gene therapy for cardiac diseases: methods, challenges, and future directions [0.03%]
心血管疾病的基因治疗：方法、挑战和未来方向
Luca Grisorio,Rossana Bongianino,Matteo Gianeselli et al.
Luca Grisorio et al.
Gene therapy is advancing at an unprecedented pace, and the recent success of clinical trials reinforces optimism and trust among the scientific community. Recently, the cardiac gene therapy pipeline, which had progressed more slowly than i...
Interleukin-12p40 deficiency attenuates myocardial ferroptosis in doxorubicin-induced chronic cardiomyopathy by inhibiting Th17 differentiation and interleukin-17A production [0.03%]
白介素-12p40缺陷通过抑制Th17分化和白介素-17A产生而削弱多柔比星致慢性心肌病小鼠心肌铁死亡
Jishou Zhang,Wen Ding,Zheng Yin et al.
Jishou Zhang et al.
Aims: Interleukin (IL)-12p40 is a common subunit of the bioactive cytokines IL-12 and IL-23, and it also has its own intrinsic functional activity. However, its role in doxorubicin-induced chronic cardiomyopathy (DICCM) a...
Activation of β3-AR by mirabegron prevents aortic dissection/aneurysm by promoting lymphangiogenesis in perivascular adipose tissue [0.03%]
通过促进血管外周脂肪组织淋巴管生成，β3肾上腺素受体激动剂Mirabegron预防主动脉夹层/动脉瘤形成
Ze-Bei Zhang,Yu-Wen Cheng,Lian Xu et al.
Ze-Bei Zhang et al.
Aims: β3-AR (β3-adrenergic receptor) is essential for cardiovascular homeostasis through regulating adipose tissue function. Perivascular adipose tissue (PVAT) has been implicated in the pathogenesis of aortic dissectio...
Circulating ECM proteins decorin and alpha-L-iduronidase differentiate ATTRwt-CM from ATTRwt-negative HFpEF/HFmrEF [0.03%]
循环ECM蛋白装饰素和α-L-艾杜糖醛酸酶区分ATTRwt-CM与ATTRwt阴性HFpEF/HFmrEF
Alwin Tubben,George Markousis-Mavrogenis,Laura M G Meems et al.
Alwin Tubben et al.
Aims: Wild-type transthyretin cardiac amyloidosis (ATTRwt-CM) is an under-recognized aetiology of heart failure (HF), necessitating early detection for timely treatment. Our study aimed to differentiate patients with ATTR...
Observational Study
Cardiovascular research. 2024 Nov 25;120(14):1727-1736. DOI:10.1093/cvr/cvae189 2024