Mechanisms and consequences of myeloid adhesome dysfunction in atherogenesis [0.03%]
髓系细胞粘附复合体功能障碍在动脉粥样硬化发生发展中的作用及机制研究
Irina Zhevlakova,Huan Liu,Tejasvi Dudiki et al.
Irina Zhevlakova et al.
Aims: In the context of atherosclerosis, macrophages exposed to oxidized low-density lipoprotein (oxLDL) exhibit cellular abnormalities, specifically in adhesome functions, yet the mechanisms and implications of these adh...
Mark Sweeney,Katie O&#x;Fee,Chelsie Villanueva-Hayes et al.
Mark Sweeney et al.
Aims: Interleukin 11 (IL11) was initially thought important for platelet production, which led to recombinant IL11 being developed as a drug to treat thrombocytopenia. IL11 was later found to be redundant for haematopoies...
Xiang Li,Yangyang Bao,Ning Zhang et al.
Xiang Li et al.
Aims: Immune cell alterations may play a role in the development of atrial fibrillation (AF). Our objective was to comprehensively characterize immune cells in AF, and investigate the potential mechanisms. ...
The cardiologist in the age of artificial intelligence: what is left for us? [0.03%]
人工智能时代的 cardiologist：我们还剩下什么？
Thomas F Lüscher,Florian A Wenzl
Thomas F Lüscher
The double-edged impact of obesity on cancer risk and treatment response: implications for atherosclerosis? [0.03%]
肥胖对癌症风险和治疗反应的双重影响：对动脉粥样硬化的影响？
Emiel P C van der Vorst,Mikael Rydén
Emiel P C van der Vorst
Coming around again [0.03%]
重头再来
Clarissa Savko,Mark A Sussman
Clarissa Savko
Fibroblast-specific TGF-β signaling mediates cardiac dysfunction, fibrosis, and hypertrophy in obese diabetic mice [0.03%]
成纤维细胞特异性TGF-β信号转导介导肥胖糖尿病小鼠心功能障碍、纤维化和肥大
Izabela Tuleta,Anis Hanna,Claudio Humeres et al.
Izabela Tuleta et al.
Aims: Transforming growth factor (TGF)-β is up-regulated in the diabetic myocardium and may mediate fibroblast activation. We aimed at examining the role of TGF-β-induced fibroblast activation in the pathogenesis of dia...
Cardiac tumour necrosis factor receptor-associated factor 7 mediates the ubiquitination of apoptosis signal-regulating kinase 1 and aggravates cardiac hypertrophy [0.03%]
肿瘤坏死因子受体相关因子7介导心肌细胞中凋亡信号调节激酶1的泛素化和心脏肥大的恶化
Yan Che,Yu-Ting Liu,Zhao-Peng Wang et al.
Yan Che et al.
Aims: Cardiac remodelling is a common pathophysiological process in the development of various cardiovascular diseases, but there is still a lack of effective interventions. Tumour necrosis receptor-associated factor 7 (T...
Cellular communication network factor 2 regulates smooth muscle cell transdifferentiation and lipid accumulation in atherosclerosis [0.03%]
细胞通讯网络因子2调节动脉粥样硬化平滑肌细胞转分化和脂质积累
Qian Xu,Jisheng Sun,Claire M Holden et al.
Qian Xu et al.
Aims: Accruing evidence illustrates an emerging paradigm of dynamic vascular smooth muscle cell (SMC) transdifferentiation during atherosclerosis progression. However, the molecular regulators that govern SMC phenotype di...
Yann Huey Ng,Yen Chin Koay,Francine Z Marques et al.
Yann Huey Ng et al.
Whilst metabolic inflexibility and substrate constraint have been observed in heart failure for many years, their exact causal role remains controversial. In parallel, many of our fundamental assumptions about cardiac fuel use are now being...