Christos P Kotanidis,Brittany Weber
Christos P Kotanidis
Inflammaging, a targetable pathway for preventing cardiovascular diseases [0.03%]
炎症性衰老：防治心血管疾病的潜在靶点
Juan Francisco Aranda,Cristina M Ramírez,María Mittelbrunn
Juan Francisco Aranda
Inflammaging, characterized by persistent chronic inflammation in older adults, has emerged as a critical factor linked to age-related diseases such as cardiovascular diseases (CVDs), metabolic disorders, and cognitive decline, which collec...
Regulation of blood pressure by METTL3 via RUNX1b-eNOS pathway in endothelial cells in mice [0.03%]
METTL3通过RUNX1b-eNOS通路在小鼠内皮细胞中调节血压
Yanhong Zhang,Xiaoxiao Yang,Mei Lan et al.
Yanhong Zhang et al.
Aims: Endothelial cells regulate vascular tone to control the blood pressure (BP) by producing both relaxing and contracting factors. Previously, we identified methyltransferase-like 3 (METTL3), a primary N6-methyladenosi...
miR-24-3p secreted as extracellular vesicle cargo by cardiomyocytes inhibits fibrosis in human cardiac microtissues [0.03%]
心肌细胞分泌的微小RNA-24-3p抑制人类心脏微型组织纤维化
Giorgia Senesi,Alessandra M Lodrini,Shafeeq Mohammed et al.
Giorgia Senesi et al.
Background and aims: Cardiac fibrosis in response to injury leads to myocardial stiffness and heart failure. At the cellular level, fibrosis is triggered by the conversion of cardiac fibroblasts (CF) into extracellular ma...
Temporal changes in mediation effects on cardiovascular and microvascular outcomes with glucagon-like peptide-1 receptor agonist therapy: a post-hoc analysis of the LEADER trial [0.03%]
利拉鲁肽对心血管和微血管影响的中介效应随时间的变化：LEADER研究的事后分析
Zi-Yang Peng,Yu-Hsuan Lee,Huang-Tz Ou et al.
Zi-Yang Peng et al.
Causal cardiovascular risk factors for dementia - insights from observational and genetic studies [0.03%]
来自观察性研究和基因研究的痴呆症因果心血管风险因素的新见解
Emilie Westerlin Kjeldsen,Ruth Frikke-Schmidt
Emilie Westerlin Kjeldsen
The escalating prevalence of dementia worldwide necessitates preventive strategies to mitigate its extensive health, psychological, and social impacts. As the prevalence of dementia continues to rise, gaining insights into its risk factors ...
PINK1-mediated mitophagy attenuates pathological cardiac hypertrophy by suppressing the mtDNA release-activated cGAS-STING pathway [0.03%]
线粒体DNA释放活化的cGAS-STING信号通路介导的Pink1突变引起的病理性心室肥大及其机制研究
Haobin Zhou,Xiao Wang,Tianyu Xu et al.
Haobin Zhou et al.
Aims: Sterile inflammation is implicated in the development of heart failure (HF). Mitochondria plays important roles in triggering and maintaining inflammation. Mitophagy is important for regulation of mitochondrial qual...
Epitranscriptomic regulation of cardiac fibrosis via YTHDF1-dependent PIEZO2 mRNA m6A modification [0.03%]
YTHDF1依赖的PIEZO2 mRNA m6A修饰介导的心脏纤维化表观转录组调控
Ji-Fei Ding,Bin Tu,Kai Song et al.
Ji-Fei Ding et al.
Aims: Mechanosensitive (MS) ion channels play a key role in heart development, physiology, and disease. However, little is known about the molecular mechanisms of the MS non-selective cationic channel Piezo family in card...
Sabrina Montuoro,Francesco Gentile,Alberto Giannoni
Sabrina Montuoro
Heart failure (HF) is characterized by autonomic nervous system (ANS) imbalance and low-grade chronic inflammation. The bidirectional relationship between the ANS and immune system (IS) is named "neuroimmune cross-talk" (NICT), and is based...