Cardioprotective effect of 19,20-epoxydocosapentaenoic acid (19,20-EDP) in ischemic injury involves direct activation of mitochondrial sirtuin 3 [0.03%]
19,20-环氧二十碳五烯酸(19,20-EDP)通过直接激活线粒体SIRT3发挥缺血损伤心脏保护作用
Ahmed M Darwesh,Liye Fang,Tariq R Altamimi et al.
Ahmed M Darwesh et al.
Aims: Although current clinical therapies following myocardial infarction have improved patient outcomes, morbidity, and mortality rates secondary to ischemic and ischemia reperfusion (IR) injury remains high. Maintaining...
CXCR4-targeted sensitive magnetic particle imaging for abdominal aortic aneurysm early detection and prognosis evaluation by recognizing total inflammatory cells [0.03%]
CXCR4靶向敏感性磁粒子成像通过识别全部炎性细胞用于腹主动脉瘤的早期检测和预后评估
Genmao Cao,Ruijing Zhang,Xiaohua Jia et al.
Genmao Cao et al.
Background: The maximum aortic diameter remains the diagnostic criteria and the indicator for prognosis prediction of abdominal aortic aneurysms (AAA). An additional imaging modality is currently needed to help evaluate t...
The m6A demethylase ALKBH5 is a novel epigenetic regulator of aortic valve calcification [0.03%]
ALKBH5去甲基化酶是一种新的主动脉瓣钙化的表观遗传调控因子
Yueheng Wang,Shengping He,Lan Lan et al.
Yueheng Wang et al.
Aims: Calcific aortic valve disease (CAVD) is a common heart valve disease with significant clinical consequences. The mechanisms that drive the pathogenesis of CAVD remain to be fully elucidated. N6-methyladenosine (m6A)...
NRF2 activation in the heart induces glucose metabolic reprogramming and reduces cardiac dysfunction via upregulation of the pentose phosphate pathway [0.03%]
NRF2激活诱导心脏葡萄糖代谢重组并通过上调戊糖磷酸途径减少心功能障碍
Anna Zoccarato,Ioannis Smyrnias,Christina M Reumiller et al.
Anna Zoccarato et al.
Aims: The transcription factor NRF2 is well recognized as a master regulator of antioxidant responses and cytoprotective genes. Previous studies showed that NRF2 enhances resistance of mouse hearts to chronic hemodynamic ...
When cell mechanics meets epitranscriptomics: reduction of m6A in Piezo2 RNA ameliorates cardiac fibrosis [0.03%]
当细胞力学遇到表转录组学：Piezo2 RNA 中 m6A 的减少可减轻心脏纤维化
Gloria Garoffolo,Maurizio Pesce
Gloria Garoffolo
Anaplerotic filling in heart failure: a review of mechanism and potential therapeutics [0.03%]
心力衰竭中补救性充填的机制及潜在治疗手段综述
Karm A Alhasan,Melissa A King,Badal S B Pattar et al.
Karm A Alhasan et al.
Heart failure (HF) is a complex syndrome and a leading cause of mortality worldwide. While current medical treatment is based on known pathophysiology and is effective for many patients, the underlying cellular mechanisms are poorly underst...
On the cusps of the second heart field: insights from zebrafish into arterial valve origins and disease [0.03%]
心场第二部分的尖端：斑马鱼动脉瓣起源与疾病的研究启示
Robert G Kelly
Robert G Kelly
TGF-β signalling: the Dr Jekyll and Mr Hyde of the aortic aneurysms [0.03%]
TGF-β信号通路：主动脉瘤中的Jekyll和Hyde效应
Sara Perrotta,Daniela Carnevale,Giuseppe Lembo
Sara Perrotta
C-C motif chemokine receptor-2 blockade ameliorates pulmonary hypertension in rats and synergizes with a pulmonary vasodilator [0.03%]
C-C基序趋化因子受体2阻断剂改善大鼠肺动脉高压并协同肺血管扩张剂的作用
Naoki Tsuboya,Hirofumi Sawada,Yoshihide Mitani et al.
Naoki Tsuboya et al.
Aims: We investigated whether the disruption of C-C motif chemokine receptor (CCR) 2 may attenuate the development of pulmonary arterial hypertension (PAH) in any rat models with the reversal of the associated pro-inflamm...
Inflammation and heart failure: are we facing a 'hedgehog's dilemma'? [0.03%]
炎症和心力衰竭：我们面临着“豪猪的困境”吗？
Stefano Ministrini,Giovanni G Camici
Stefano Ministrini