Marek Rajzer,Wiktoria Wojciechowska
Marek Rajzer
KMT2B drives inflammation in endothelial cells and promotes atherosclerosis via histone H3 lysine 4 trimethylation-mediated autophagy [0.03%]
KMT2B通过组蛋白H3赖氨酸4三甲基化介导的自噬在内皮细胞中驱动炎症并促进动脉粥样硬化发生发展
Fuyuan Zhang,Rong Fu,Zhongxiao Lin et al.
Fuyuan Zhang et al.
Aims: Atherosclerosis is a chronic condition characterized by persistent inflammation and vascular remodeling. Oxidized low-density lipoprotein (ox-LDL) plays a central role in this process by promoting inflammation and i...
LMNA p.H222P mutation causes contractile dysfunction via impaired mitochondrial calcium uptake in human cardiac laminopathy [0.03%]
LMNA p.H222P突变通过干扰人体心脏黏液病线粒体钙摄取导致收缩功能障碍
Magali Seguret,Charlène Jouve,Andrea Ruiz-Velasco et al.
Magali Seguret et al.
Aims: Mutations in the LMNA gene, which encodes lamin A/C, cause a variety of diseases known as laminopathies. Some mutations are particularly associated with the occurrence of dilated cardiomyopathy and heart failure, bu...
Klytaimnistra Kiouptsi,Olga Dremova,Christoph Reinhardt
Klytaimnistra Kiouptsi
Julia E Visch,Ali Nassar,George Burchell et al.
Julia E Visch et al.
Aims: Hypertrophic cardiomyopathy (HCM) is characterized by left ventricular hypertrophy along with (micro)vascular abnormalities. These include cardiac and peripheral vascular dysfunction, as well as structural vascular ...
Long-term mavacamten exposure reduces force and sarcomere density in a hiPSC model of hypertrophic cardiomyopathy [0.03%]
长期使用mavacamten可减少心肌病hiPSC模型中的力量和横纹肌丝密度
Marianna Langione,Lucrezia Giammarino,Roberto Semeraro et al.
Marianna Langione et al.
Cardiomyocyte T-tubule loss in heart failure - NFκB as a central signalling hub [0.03%]
心力衰竭中心肌细胞T小管丢失与NF-κB作为关键信号转接中心的作用关系研究
Viacheslav O Nikolaev,Julia Gorelik
Viacheslav O Nikolaev
Age-associated B-cells predict coronary events in humans and aggravate murine atherosclerosis [0.03%]
年龄相关B细胞可预测人类冠状动脉事件并加重动脉粥样硬化小鼠病情
Jill de Mol,Pernilla Katra,Virginia Smit et al.
Jill de Mol et al.
Aims: Aging is a major risk factor for cardiovascular disease (CVD) and is also linked to a functional decline of the immune system. B-cells contribute to atherosclerosis progression by antibody secretion, antigen present...
Atrial fibrillation in patients with left ventricular non-compaction: incidence and associations with stroke, heart failure, and mortality [0.03%]
左心室非补偿性患者的房颤发病率及其与中风、心力衰竭和死亡率的关系
Amir Askarinejad,Thomas F Lüscher,Gregory Y H Lip
Amir Askarinejad
Aims: Left ventricular non-compaction (LVNC) is a genetic cardiomyopathy with presentations ranging from asymptomatic disease to heart failure, stroke, and sudden cardiac death. LVNC-related structural and functional abno...
Interleukin-17A mediates cardiorenal injury in oxalate nephropathy [0.03%]
interleukin-17A介导草酸肾病的心肾损伤
Moritz I Wimmer,Martin Reichel,Arne Thiele et al.
Moritz I Wimmer et al.
Aims: Cardiovascular disease (CVD) is the leading cause of mortality in chronic kidney disease (CKD). While CKD is known to give rise to systemic inflammation, its inciting factors remain poorly defined. Oxalate, long imp...