Yamen Adrah,Niklas Hegemann,David Faidel et al.
Yamen Adrah et al.
Aims: Heart failure (HF) with preserved ejection fraction (HFpEF) has become the most diagnosed HF subtype representing a major public health burden with poor clinical outcome. Available treatment options for HFpEF are li...
Decoding ETV2 networks driving endothelial specification and cardiac repression [0.03%]
解析ETV2网络在促进内皮细胞分化和心脏抑制中的作用
Yena Oh,Sean M Wu
Yena Oh
Iron regulatory proteins secure iron availability in skeletal muscle to preserve exercise tolerance in heart failure [0.03%]
铁调节蛋白通过向心力衰竭骨骼肌中提供铁来维持运动耐受性
Bomee Chung,Wenke Jonas,Fatemeh Rostami et al.
Bomee Chung et al.
Aims: Iron deficiency (ID) is a frequent comorbidity in heart failure (HF) and contributes to exercise intolerance. Tissue iron levels are maintained by cellular iron uptake, sequestration, and release, processes that are...
Beyond triglycerides lowering: rethinking the role of eicosapentaenoic acid in lipoprotein biology [0.03%]
二十碳五烯酸的脂蛋白生物学作用再思考——不仅仅降低三酰甘油水平
Amedeo Tirandi,Anina Künzli,Giovanni G Camici
Amedeo Tirandi
Gerd Heusch,Petra Kleinbongard
Gerd Heusch
Oxidized LDL-induced FOXS1 mediates cholesterol transport dysfunction and inflammasome activation to drive aortic valve calcification [0.03%]
氧化型低密度脂蛋白诱导的FOXS1介导胆固醇转运功能障碍和炎症小体激活以促进主动脉瓣钙化
Chen Jiang,Dingyi Yao,Qiang Shen et al.
Chen Jiang et al.
Aims: Calcific aortic valve disease (CAVD) is becoming more prevalent with the population ageing; however, there is currently no medical therapy available. During early lipid deposition, low-density lipoprotein (LDL) medi...
Invasive validation of novel 1D models for computation of coronary fractional flow reserve [0.03%]
新型一维冠状动脉血流储备分数计算模型的有创验证研究
Daniel J Taylor,Harry Saxton,Xu Xu et al.
Daniel J Taylor et al.
Introduction: Computed virtual fractional flow reserve (vFFR), derived from invasive angiography, non-invasively quantifies coronary epicardial lesion physiology. Developments of 1D vFFR models have introduced methods of ...
oxLDL-induced aortic valve inflammation and calcification - opportunities for clinical translation [0.03%]
氧化型低密度脂蛋白诱发的主动脉瓣炎症和钙化及临床转化机遇
Yu-Jen Wang,Michael A Matter,Christian M Matter
Yu-Jen Wang
Marco Micillo,Giuseppe Lembo
Marco Micillo
Impaired coronary flow reserve by hyperviscosity in a mouse model of non-light chain multiple myeloma - a mechanism of coronary flow impairment at the capillary level [0.03%]
在非轻链型多发性骨髓瘤小鼠模型中，由于血黏度增高导致冠状动脉流储备能力下降——毛细血管水平上冠脉灌注受损的机制
Aleksandra Paterek,Filip Rolski,Mateusz Surzykiewicz et al.
Aleksandra Paterek et al.
Aims: Multiple myeloma (MM) is associated with cardiovascular risk, although the exact underlying mechanisms are unknown. Here we tested the hypothesis that MM impairs coronary flow reserve due to increased blood viscosit...