Brainstem C1 neurons mediate heart failure decompensation and mortality during acute salt loading [0.03%]
急性高盐负荷心衰加重和死亡的脑干C1神经元介导机制
Karla G Schwarz,Katherin V Pereyra,Esteban Díaz-Jara et al.
Karla G Schwarz et al.
Aims: Heart failure (HF) is an emerging epidemic worldwide. Despite advances in treatment, the morbidity and mortality rate of HF remain high, and the global prevalence continues to rise. Common clinical features of HF in...
Chemokine receptor-directed imaging, prognostication, and treatment of abdominal aortic aneurysm: can we do it all with CXCR4? [0.03%]
趋化因子受体导向的腹主动脉瘤影像学检查、预后及治疗：CXCR4能胜任吗？
Martin Andreas,Irene M Lang
Martin Andreas
Arne Thiele,Hendrik Bartolomaeus,Harithaa Anandakumar et al.
Arne Thiele et al.
Cardioprotection exerted by intravenous statin at index myocardial infarction event attenuates cardiac damage upon recurrent infarction [0.03%]
他汀类药物在首次心肌梗死时静脉给药对再次发生心梗导致的心脏损伤具有保护作用
Gemma Vilahur,Soumaya Ben-Aicha,Manuel Gutiérrez et al.
Gemma Vilahur et al.
Aims: Recurrent acute myocardial infarction (RE-AMI) is a frequent complication after STEMI, and its association with stent thrombosis can be life-threatening. Intravenous atorvastatin (IV-atorva) administration during AM...
Taming the flame: SerpinB1 suppression of pyroptosis in pathological cardiac hypertrophy [0.03%]
降火焰：丝裂酶抑制蛋白B1在病理性心脏肥厚中抑制焦亡作用
Beatrijs Bartelds,Daphne Merkus
Beatrijs Bartelds
SGLT2 expression in human vasculature and heart correlates with low-grade inflammation and causes eNOS-NO/ROS imbalance [0.03%]
人血管和心脏中SGLT2的表达与低度炎症相关并导致eNOS-NO/ROS失衡
Ali Mroueh,Paola Algara-Suarez,Walaa Fakih et al.
Ali Mroueh et al.
Aims: Sodium-glucose co-transporter 2 inhibitors (SGLT2i) show a cardioprotective effect in heart failure and myocardial infarction, pathologies often associated with low-grade inflammation. This cross-sectional study aim...
Iron, lipid peroxidation and ferroptosis play pathogenic roles in atherosclerosis [0.03%]
铁、脂质过氧化和铁死亡在动脉粥样硬化中起致病作用
Swetha Jinson,Ziyang Zhang,Graeme I Lancaster et al.
Swetha Jinson et al.
Oxidation of lipids, excessive cell death and iron deposition are prominent features of human atherosclerotic plaques. While extensive research has established the detrimental roles of lipid oxidation and apoptosis in atherosclerosis develo...
Meis transcription factors regulate cardiac conduction system development and adult function [0.03%]
meis转录因子调控心脏传导系统发育及成人功能
Noelia Muñoz-Martín,Ana Simon-Chica,Covadonga Díaz-Díaz et al.
Noelia Muñoz-Martín et al.
Aims: The Cardiac Conduction System (CCS) is progressively specified during development by interactions among a discrete number of Transcriptions Factors that ensure its proper patterning and the emergence of its function...
SerpinB1 targeting safeguards against pathological cardiac hypertrophy and remodelling by suppressing cardiomyocyte pyroptosis and inflammation initiation [0.03%]
靶向 SerpinB1 抑制心肌细胞焦亡和炎症发生 确保心脏免受病理性肥大及重塑的伤害
Cong Lan,Gangyao Fang,Xiuchuan Li et al.
Cong Lan et al.
Aims: While the pivotal role of inflammation in pathological cardiac hypertrophy and remodelling is widely acknowledged, the mechanisms triggering inflammation initiation remain largely obscure. This study aims to elucida...