Angiotensin 1-7 and a TERT activator individually restore vasodilatory capacity within the microcirculation previous SARS-CoV-2 infection [0.03%]
血管紧张素1-7和TERT激活剂分别恢复SARS-CoV-2感染后的微循环血管舒张能力
Yoshinori Nishijima,Shelby N Hader,Erin C Birch et al.
Yoshinori Nishijima et al.
Joshua A Keefe,Jian Wang,Jiangping Song et al.
Joshua A Keefe et al.
Cardiac arrhythmias are a significant cause of morbidity and mortality worldwide. Emerging evidence has demonstrated that resident and infiltrating cardiac immune cells play direct, mechanistic roles in arrhythmia onset and progression. In ...
Glucose-dependent insulinotropic polypeptide/glucagon-like peptide 1 receptor agonist tirzepatide promotes branched chain amino acid catabolism to prevent myocardial infarction in non-diabetic mice [0.03%]
葡萄糖依赖性胰岛素多肽/胰高血糖素样肽1受体激动剂 Tirzepatide通过促进支链氨基酸分解代谢来预防非糖尿病小鼠心肌梗死
Mengya Chen,Nan Zhao,Wenke Shi et al.
Mengya Chen et al.
Aims: A novel dual glucose-dependent insulinotropic polypeptide and glucagon-like peptide 1 receptor agonist, tirzepatide (LY3298176, TZP), has been developed to treat Type 2 diabetes mellitus (T2DM). In ischaemic heart d...
Interleukin-37 attenuates aortic valve lesions by inhibiting m6A-mediated IRAK-M degradation [0.03%]
通过抑制m6A介导的IRAK-M降解，白细胞介素37可减轻主动脉瓣病变
Gaopeng Xian,Rong Huang,Dongtu Hu et al.
Gaopeng Xian et al.
Aims: Calcific aortic valve disease (CAVD) has become an increasingly important global medical problem without effective pharmacological intervention. Accumulating evidence indicates that aortic valve calcification is dri...
Single cell RNA sequencing of hematopoietic cells in fresh and frozen human atheroma tissue [0.03%]
新鲜和冻存的人动脉粥样硬化组织中的单细胞RNA测序及造血细胞分析
Herra Ahmad,J K Gopakumar,Daniel C Nachun et al.
Herra Ahmad et al.
Aims: Single-cell RNA sequencing (scRNA-seq) is a powerful method for exploring the cellular heterogeneity within human atheroma but typically requires fresh tissue to preserve cell membrane integrity, limiting the feasib...
CircRNAs increase during vascular cell differentiation and are biomarkers for vascular disease [0.03%]
环状circRNA在血管细胞分化过程中表达量增加并可作为血管疾病的生物标志物
Bernd H Northoff,Andreas Herbst,Catharina Wenk et al.
Bernd H Northoff et al.
Aims: The role of circular RNAs (circRNAs) and their regulation in health and disease are poorly understood. Here, we systematically investigated the temporally resolved transcriptomic expression of circRNAs during differ...
Incretin-based weight loss therapies and heart failure with preserved ejection fraction: guideline impactful results, but mechanisms unclear [0.03%]
基于肠降糖素的减肥疗法与射血分数保留的心力衰竭：具有指南影响力的成果，但机制尚不清楚
Katarzyna Stefanska,Naveed Sattar
Katarzyna Stefanska
Downregulation of HDAC2 attenuates ventricular arrhythmias in a mouse model of cardiac hypertrophy through upregulation of KCHIP2 expression [0.03%]
组蛋白去乙酰化酶2下调通过上调KCHIP2表达抑制心肌肥厚小鼠室性心律失常
Wenjuan Liu,Jianping Liu,Gang Wang et al.
Wenjuan Liu et al.
Aims: Decrease in repolarizing K+ currents, particularly the fast component of transient outward K+ current (Ito,f), prolongs action potential duration (APD) and predisposes the heart to ventricular arrhythmia during card...