Abel Martin-Garrido,Joerg Heineke
Abel Martin-Garrido
Restoring balance with recombinant interleukin-37: hope for halting chronic inflammation in calcific aortic valve disease [0.03%]
重组白细胞介素37恢复平衡：控制钙化性主动脉瓣疾病慢性炎症的希望
Nalin H Dayawansa,Sara Baratchi,Karlheinz Peter
Nalin H Dayawansa
The Mediterranean diet displays an immunomodulatory effect that correlates with beneficial changes in carotid atherosclerosis [0.03%]
地中海饮食显示出与有益的变化在颈动脉粥样硬化相关的免疫调节作用
Ana María Ruiz-León,Miguel Camafort,Aleix Sala-Vila et al.
Ana María Ruiz-León et al.
Bone morphogenetic protein 10 is increased in precapillary pulmonary hypertension patients [0.03%]
前毛细血管性肺动脉高压患者骨形态发生蛋白10增加
Aida Llucià-Valldeperas,Jessie van Wezenbeek,Joanne A Groeneveldt et al.
Aida Llucià-Valldeperas et al.
Aims: Precapillary pulmonary hypertension (precPH) results in increased right atrial (RA) stretch and pressure. The right atrium is the major source of bone morphogenetic protein 10 (BMP10) in adults, primarily produced b...
Endothelial c-REL orchestrates atherosclerosis at regions of disturbed flow through crosstalk with TXNIP-p38 and non-canonical NF-κB pathways [0.03%]
内皮c-REL通过与TXNIP-p38和非典型NF-κB通路的串扰在湍流区域协调动脉粥样硬化
Blanca Tardajos Ayllon,Neil Bowden,Celine Souilhol et al.
Blanca Tardajos Ayllon et al.
Aims: Atherosclerosis initiation at sites of disturbed blood flow involves heightened inflammation coupled to excessive endothelial cell (EC) proliferation. Here, we unveil the pivotal role of c-REL, a member of the NF-κ...
METTL3-catalyzed m6A methylation facilitates the contribution of vascular smooth muscle cells to atherosclerosis [0.03%]
METTL3介导的m6A甲基化促进血管平滑肌细胞在动脉粥样硬化中发挥作用
Zhigang Dong,Yourong Jin,Yicong Shen et al.
Zhigang Dong et al.
Aims: Vascular smooth muscle cells (VSMCs) are involved in the etiology of atherosclerosis, but whether methyltransferase-like 3 (METTL3)-catalyzed N6-methyladenosine (m6A) modulates the contribution of VSMCs to atheroscl...
TAOK1 suppression improves doxorubicin-induced cardiomyopathy by preventing cardiomyocyte death and dysfunction [0.03%]
TAOK1抑制通过防止心肌细胞死亡和功能障碍来改善多柔比星诱导的心肌病
Takaomi Suga,Tomoya Kitani,Masaya Kogure et al.
Takaomi Suga et al.
Aims: Doxorubicin (DOX) is one of the most effective chemotherapeutic agents for various types of cancers. However, DOX often causes cardiotoxicity, which is referred to as DOX-induced cardiomyopathy (DIC). Despite extens...
Cardiomyocyte SORBS2 expression increases in heart failure and regulates integrin interactions and extracellular matrix composition [0.03%]
心力衰竭时心肌细胞SORBS2的表达增加并调节整联蛋白相互作用和细胞外基质组成
Louk T Timmer,Elvira den Hertog,Danielle Versteeg et al.
Louk T Timmer et al.
Aims: In this study, we aimed to uncover genes associated with stressed cardiomyocytes by combining single-cell transcriptomic datasets from failing cardiac tissue from both humans and mice. ...
Stretch regulation of β2-Adrenoceptor signalling in cardiomyocytes requires caveolae [0.03%]
心肌细胞β2-肾上腺素受体信号转导的伸展调节需要微凹结构存在
Jiarong Fu,Catherine Mansfield,Ivan Diakonov et al.
Jiarong Fu et al.
Aims: Caveolin-3 is essential for the formation of caveolae in cardiomyocytes. Caveolar microdomains have been shown to regulate the distribution of signalling proteins such as beta-adrenoceptors (βAR) and may act as mem...
Valtteri Muroke,Jean-Claude Tardif
Valtteri Muroke