Antisense-mediated regulation of exon usage in the elastic spring region of Titin modulates sarcomere function [0.03%]
反义介导的巨蛋白弹性弹簧区外显子使用情况的调节可改变肌节功能
Selvi Celik,Ludvig Hyrefelt,Tomasz Czuba et al.
Selvi Celik et al.
Background: Alternative splicing of Titin (TTN) I-band exons produce protein isoforms with variable size and elasticity, but the mechanisms whereby TTN splice factors regulate exon usage and thereby determining cardiomyoc...
Vasoconstriction-inhibiting factor: an endogenous inhibitor of vascular calcification as a calcimimetic of calcium-sensing receptor [0.03%]
血管收缩抑制因子：作为钙感应受体的拟钙剂内源性血管钙化抑制因子
Sofía de la Puente-Secades,Dustin Mikolajetz,Nathalie Gayrard et al.
Sofía de la Puente-Secades et al.
Aims: Patients with chronic kidney disease (CKD) show a high risk of cardiovascular diseases, predominantly caused by accelerated vascular calcification. Vascular calcification is a highly regulated process with no curren...
Targeted delivery of TAPI-1 via biomimetic nanoparticles ameliorates post-infarct left ventricle function and remodeling [0.03%]
通过生物仿真纳米粒子对TAPI-1进行靶向递送改善心肌梗死后的左心室功能和重构
Qing Chen,Yang Yu,Lei Tong et al.
Qing Chen et al.
Aims: The potential of nanoparticles as effective drug delivery tools for treating failing hearts in heart failure remains a challenge. Leveraging the rapid infiltration of neutrophils into infarcted hearts after myocardi...
Targeting the PDK/PDH axis modulates neutrophil and smooth muscle cell pathological responses and prevents abdominal aortic aneurysm formation [0.03%]
靶向PDK / PDH轴可调节中性粒细胞和平滑肌细胞的病理反应并防止腹主动脉瘤的形成
S Griepke,A Grentzmann,G L Tripodi et al.
S Griepke et al.
Aims: Abdominal aortic aneurysm (AAA) is a life-threatening condition where inflammation plays a key role. Currently, AAA treatment relies exclusively on surgical interventions, and no guideline drug therapy to prevent an...
Joanna Stuck,Islam Osman
Joanna Stuck
A novel long-acting relaxin-2 fusion, AZD3427, improves cardiac performance in non-human primates with cardiac dysfunction [0.03%]
新型长效的relaxin-2融合蛋白AZD3427改善心功能不全的非人灵长类动物的心脏表现
Monika Papworth,Spoorthy Kulkarni,Madeleine Antonsson et al.
Monika Papworth et al.
Aim: Relaxin-2, a well-known human hormone primarily associated with pregnancy, has shown promising cardiovascular benefits in both preclinical models and clinical trials. However, its therapeutic potential has been limit...
Tirzepatide alleviates doxorubicin-induced cardiotoxicity via inhibiting HRD1-mediated Nrf2 ubiquitination [0.03%]
Tirzepatide通过抑制HRD1介导的Nrf2泛素化来缓解多柔比星诱导的心脏毒性
Dan Yang,Yang-Hao Chen,Yan-Kun Chen et al.
Dan Yang et al.
Background: Doxorubicin (DOX), an effective and commonly used chemotherapeutic agent, often triggers dosage-dependent and potentially lethal cardiotoxicity, which heavily limits its clinical application in cancer survivor...
Evidence for intermittent coupling of intramyocardial small, engineered heart tissues acutely implanted into rabbit myocardium [0.03%]
兔心肌急性植入的小的工程化心肌组织之间的间歇性耦合的证据
E Huethorst,M J Bishop,F L Burton et al.
E Huethorst et al.
Aims: Electrical integration of human iPSC-derived cardiomyocyte (hiPSC-CM)-based tissue with the host myocardium is a requirement of successful regeneration therapy. This study was designed to identify electrical couplin...
Anti-senescence therapies: a new concept to address cardiovascular disease [0.03%]
抗衰老疗法：应对心血管疾病的全新理念
Stevan D Stojanović,Thomas Thum,Johann Bauersachs
Stevan D Stojanović
Accumulation of senescent cells is an increasingly recognized factor in the development and progression of cardiovascular disease. Senescent cells of different types display a pro-inflammatory and matrix remodeling molecular program, known ...
Rui Adão,Costantino Iadecola
Rui Adão