Dysregulated Klotho and FGF23 signaling aggravates vascular remodeling in age-related pulmonary hypertension [0.03%]
克氏因子和FGF23信号通路失调加重年龄相关性肺动脉高压的血管重塑
Paul-Lennard Perret,Jonathan H Kim,Annika Winkler et al.
Paul-Lennard Perret et al.
Aims: Pulmonary arterial hypertension (PAH) is a chronic condition of elevated pulmonary arterial pressure caused by vascular remodeling due to increased proliferation of pulmonary arterial smooth muscle cells (PASMC). In...
Mayinuer Yusufu,Algis J Vingrys,Bin Wang et al.
Mayinuer Yusufu et al.
Aims: To investigate the use of retinomics as a composite biomarker for incident heart diseases, leveraging the multidimensional relationships between vascular parameters from colour fundus photography (CFP) and neural pa...
In vivo assessment of the recovery of myocardial pyruvate dehydrogenase activity following a ketogenic diet [0.03%]
生酮饮食对心肌丙酮酸脱氢酶活性恢复的体内评估
Jun Chen,Zohreh Erfani,Abdallah Elnwasany et al.
Jun Chen et al.
Aims: A ketogenic diet (KD) can suppress cardiac carbohydrate utilization, which may adversely impact heart function. However, the reversibility of KD-induced metabolic changes is poorly understood. This study aims to cha...
A randomized, double-blind, crossover study of acute low-level night-time road traffic noise: effects on vascular function, sleep, and proteomic signatures in healthy adults [0.03%]
急性低水平夜间道路交通噪声的随机双盲交叉研究：对健康成年人血管功能、睡眠和蛋白质组特征的影响
Omar Hahad,Patrick Foos,Jonas Hübner et al.
Omar Hahad et al.
Aims: Road traffic noise is the dominant source of environmental noise in Europe and a recognized cardiovascular risk factor, yet direct mechanistic evidence from human studies remains limited. This study investigated the...
Fleur V Y Tjong,Isabelle C Van Gelder
Fleur V Y Tjong
Anticoagulants beyond coagulation: a narrative review of cardiovascular effects [0.03%]
抗凝药物的非凝血作用：心血管影响叙述性综述
Annisa Aarts,Hugo Ten Cate,Arina J Ten Cate-Hoek
Annisa Aarts
Anticoagulants are widely used to prevent and treat thrombotic disorders, and continuous advances have refined their efficacy and safety. Beyond their established anticoagulant function, growing evidence indicates that some agents exert add...
Sodium-myo-inositol cotransporter-1: a missing metabolic-calcium link in pathological cardiac hypertrophy [0.03%]
病理心脏肥厚中缺失的代谢-钙离子联系：钠-肌醇共转运体-1
Hidekazu Kondo,Naohiko Takahashi
Hidekazu Kondo
Sodium-myo-inositol cotransporter-1, SMIT1, promotes cardiac hypertrophy and fibrosis induced by pressure overload in mice [0.03%]
钠-肌醇协同转运蛋白-1通过促进压力超负荷诱导的小鼠心室肥厚和纤维化发挥作用
Alice Marino,Julien Cumps,Laura Guilbert et al.
Alice Marino et al.
Aims: Recent clinical studies have reported that myo-inositol is consistently elevated in plasma of patients with heart failure (HF), yet its role in cardiac dysfunction remains poorly understood. Myo-inositol is specific...
SEMA7A-mediated regulation of smooth muscle cell plasticity in AAA: a potential intersection with metabolic reprogramming in the aortic wall [0.03%]
SEMA7A介导的马凡综合征患者腹主动脉瘤平滑肌细胞可塑性调控：与主动脉壁代谢重编程的潜在交汇点
Daniel F J Ketelhuth
Daniel F J Ketelhuth