The border zone after myocardial infarction: clarification of terminology and proposal for a new definition [0.03%]
心肌梗死后边界区：术语的澄清及新定义的建议
Emil K S Espe,William E Louch,Godfrey L Smith et al.
Emil K S Espe et al.
Solbinsiran, a durable GalNAc-conjugated siRNA targeting ANGPTL3 in adults with mixed dyslipidaemia (PROLONG-ANG3): lessons from a randomized, placebo-controlled, phase 2 trial [0.03%]
一项关于成人混合型血脂异常的随机、双盲、安慰剂对照II期试验：溶生物素化靶向血管生成素样蛋白3的GalNA凝集素缀合小干扰RNA(Solbinsiran)(PROLONG-ANG3)：针对ANPTL3成年患者的长效siRNA疗法的一项随机、安慰剂对照2期临床试验中的经验教训
Dídac Llop,Kausik K Ray
Dídac Llop
Shared splicing dysregulation in heart failure associated with dilated and ischemic cardiomyopathy and spatial specificity across cardiac regions [0.03%]
与扩张性和缺血性心肌病相关的心力衰竭中共同的剪接失调及心脏各区域的空间特异性
Marta Furtado,Pedro Barbosa,Ana Wemans et al.
Marta Furtado et al.
Aims: Alternative splicing plays a critical role in cardiac development and function and becomes dysregulated in heart failure. Although splicing defects have been described in both dilated (DCM) and ischemic (ICM) cardio...
METTL14 inhibits atherogenesis by epigenetically activating PPAR-α/γ transcription and fatty acid oxidation in VSMCs [0.03%]
METTL14通过表观遗传活化血管平滑肌细胞中的PPAR-α/γ转录和脂肪酸氧化抑制动脉粥样硬化发生
Lei Cui,Cheng Kiu Ho,Panhong Liang et al.
Lei Cui et al.
Aims: N6-methyladenosine (m6A) RNA modification can govern cell fate by co- or post-transcriptionally regulating gene expression. VSMCs can undergo phenotypic switching, contributing to other cells within atherosclerotic ...
SGLT2 inhibitors but not other antidiabetic drugs improve frailty in older adults with diabetes and HFpEF [0.03%]
钠-葡萄糖共转运蛋白2抑制剂而非其他抗糖尿病药物可改善糖尿病和射血分数保留型心力衰竭老年人的虚弱状况
Pasquale Mone,Marco Ferrone,Francesco Spione et al.
Pasquale Mone et al.
The impact of environmental pollution and climate change on hypertension: a position paper by the European Society of Hypertension (ESH) Working Group on Environment in Hypertension [0.03%]
环境因素与高血压欧洲高血压学会(ESH)工作组立场文件
Marek Rajzer,Wiktoria Wojciechowska,Andrzej Januszewicz et al.
Marek Rajzer et al.
Environmental pollution - including air, noise, and light - and progressive climate change are major contributors to global health burdens, responsible for over 9 million premature deaths annuallysa. Among environmental exposures, air and n...
Suppressor of variegation 3-9 homolog 1 deficiency attenuates cardiac fibrosis and rescues heart failure through TACC2 [0.03%]
Suppressor of variegation 3-9同源物1缺乏通过TACC2减轻心脏纤维化并救治心力衰竭
Chenghao Zhu,Yujia Xue,Wenxuan Hong et al.
Chenghao Zhu et al.
Aims: Aberrant and excessive cardiac fibrosis contributes to heart failure. Resident cardiac fibroblasts are the primary source of myofibroblasts that produce extracellular matrix proteins to mediate cardiac fibrosis. Pre...
Nuclear export by COPS5/CSN5/JAB1 mediates vascular smooth muscle cell dedifferentiation in neointimal hyperplasia [0.03%]
COPS5/CSN5/JAB1介导的核输出促进血管平滑肌细胞去分化和新生内膜形成
Samiksha Giri,Chao Suo,Ruggero Pardi et al.
Samiksha Giri et al.
Aims: Vascular smooth muscle cell (VSMC) phenotypic remodeling is pivotal to neointimal hyperplasia (NH), a common pathological response to vascular injury. COPS5/CSN5/JAB1 harbors the deneddylase of the COP9 signalosome ...
The PIEZO1 paradox: an ion channel at the crossroads of mechanics and metabolism in pulmonary disease [0.03%]
PIEZO1通道蛋白悖论：力学和代谢在肺部疾病中的交汇点
Ingrid Fleming
Ingrid Fleming
Lgi3-4 proteins modulate the KV1.5 channelosome and are potential therapeutic targets for atrial fibrillation [0.03%]
Lgi3-4蛋白通过调节KV1.5通道体并具有治疗房颤的潜力
Paula G Socuéllamos,Álvaro Macías,Ángela de Benito-Bueno et al.
Paula G Socuéllamos et al.
Aims: We investigated the role of Lgi3-4 proteins in cardiac electrophysiology, with a specific focus on IKur, and their potential contribution to the pathophysiology of atrial fibrillation (AF). ...