Synonymous but Significant: New Findings of Pathological Variants in Hermansky-Pudlak Syndrome [0.03%]
同义但重要：Hermansky-Pudlak综合征病理变异的新发现
Junnosuke Kawaguchi,Ken Okamura,Toru Saito et al.
Junnosuke Kawaguchi et al.
Hermansky-Pudlak syndrome (HPS) is a rare autosomal recessive disorder characterized by oculocutaneous albinism and systemic complications, including bleeding tendencies. While 11 genes associated with HPS have been identified, cases of HPS...
Effectiveness and Safety of Oral Compound Glycyrrhizin Followed by Phototherapy for the Treatment of Progressive Vitiligo in Children [0.03%]
口服甘草酸复合物联合光疗治疗儿童进展期白癜风的疗效及安全性研究
Li Zhang,Jian Zhang,Suqing Liu et al.
Li Zhang et al.
Childhood vitiligo, distinct from its adult counterpart, presents unique treatment challenges. Glycyrrhizin inhibits the release of high-mobility group box 1 (HMGB1) protein from keratinocytes, preventing melanocyte apoptosis and autophagy....
Randomized Controlled Trial
Pigment cell & melanoma research. 2025 Mar;38(2):e13226. DOI:10.1111/pcmr.13226 2025
A Unique Signature for Cancer-Associated Fibroblasts in Melanoma Metastases [0.03%]
黑色素瘤转移灶中癌相关成纤维细胞的特有标志signature
Saskia Tauch,Joschka Hey,Bettina Kast et al.
Saskia Tauch et al.
Cancer-associated fibroblasts (CAFs) represent a central cell population of the tumor microenvironment (TME). Recently, single-cell RNA-sequencing (scRNA-seq) analyses of primary tumors of different cancer entities yielded different classif...
Melanin and Neurotransmitter Signalling Genes Are Differentially Co-Expressed in Growing Feathers of White and Rufous Barn Owls [0.03%]
白林雕和红林雕羽毛生长过程中黑色素和神经递质信号基因的差异共表达
Anne-Lyse Ducrest,Luis M San-Jose,Samuel Neuenschwander et al.
Anne-Lyse Ducrest et al.
Regulation of melanin-based pigmentation is complex, involving multiple genes. Because different genes can contribute to the same pigmentation phenotype, the genes identified in model organisms may not necessarily apply to wild species. In ...
Sensory Symptoms as an Early Manifestation of Active Vitiligo: A Case-Control Clinical and Molecular Study [0.03%]
感觉症状作为活性白癜风早期表现的病例对照临床和分子研究
Hagar El Sayed,Hala El Wakeel,Zeinab Nour et al.
Hagar El Sayed et al.
Vitiligo pathogenesis is complex. There is some evidence in support of the neurohormonal pathways involved. Although considered a nonpruritic condition, some patients may experience itching, which can occur ahead of the appearance of the pa...
Tokimasa Hida
Tokimasa Hida
The Melanocyte and Nerve Fiber Cross-Talk, Facilitated Also by Semaphorin-4A, Enhances UV-B-Induced Melanogenesis [0.03%]
色素细胞和神经纤维的交叉谈话通过分节素-4A促进紫外线B诱导的黑色素生成增强作用
Onur Egriboz,Markus Fehrholz,Moe Tsutsumi et al.
Onur Egriboz et al.
Epidermal melanocytes form synaptic-like contacts with cutaneous nerve fibers, but the functional outcome of these connections remains elusive. In this pilot study we used our fully humanized re-innervated skin organ culture model to invest...
Interplay of Light, Melatonin, and Circadian Genes in Skin Pigmentation Regulation [0.03%]
光、褪黑素和昼夜基因在皮肤色素沉着调节中的相互作用
Gabriel E Bertolesi,Nilakshi Debnath,Neda Heshami et al.
Gabriel E Bertolesi et al.
Circadian regulation of skin pigmentation is essential for thermoregulation, ultraviolet (UV) protection, and synchronization of skin cell renewal. This regulation involves both cell-autonomous photic responses and non-cell-autonomous hormo...
Beta-Blockers and Cutaneous Melanoma Outcomes: A Systematic Review and Random-Effects Meta-Analysis [0.03%]
β受体阻滞剂与皮肤黑色素瘤预后的系统评价和随机效应meta分析
Nicholas M Muller,Samuel X Tan,Nisal Vipulaguna et al.
Nicholas M Muller et al.
Beta-blockers have generated an exciting discourse for their potential as a cheap, safe, and effective adjunctive therapy for cutaneous melanoma patients, but the field remains murky. This systematic review investigates the association betw...