Oral Melanoma in Older Adults: Epidemiology, Molecular Landscape, and Treatment Strategies [0.03%]
老年人口腔黑色素瘤的流行病学、分子特征和治疗策略
José Alcides Almeida de Arruda,Victor Zanetti Drumond,Jefferson R Tenório et al.
José Alcides Almeida de Arruda et al.
Oral melanoma is an aggressive neoplasm arising from melanocytes in the mucosal epithelium, accounting for 0.2%-0.8% of all melanomas. Unlike cutaneous melanoma, it is not associated with UV exposure, and its pathogenesis involves complex g...
Melanoma and Matrimony: Retrospective Study of Demographics, Marital Status, and Clinical Features of Patients With Acral Melanoma at a Single Academic Center [0.03%]
肢端黑色素瘤患者的回顾性研究——人口统计学、婚姻状况及临床特征分析
Samantha Jo Albucker,Amar D Desai,Julianne M Falotico et al.
Samantha Jo Albucker et al.
Acral melanoma (AM) is localized to the hands and feet including the palms, soles, fingers, toes, and nails, and is associated with a high degree of morbidity and mortality. It has a greater proportional incidence in non-White patients and ...
The Role of Two Tyrosinase-Like Glycoenzymes in Defining the Final Hue of Parrot Plumage [0.03%]
两种酪氨酸类似糖酶在定义鹦鹉羽毛最终色调中的作用
Shatadru Ghosh Roy,Jindřich Brejcha,Peter Mojzeš et al.
Shatadru Ghosh Roy et al.
Recent advances in avian melanogenesis have pinpointed multiple genetic loci associated with color polymorphisms, predominantly in the plumage of chickens, quails, and pigeons. However, the genetic basis of melaninization in parrot plumage ...
Unusual Autosomal Dominant Inheritance of Oculocutaneous Albinism Type 4 (OCA-4): Clinical and Functional Features From A Chinese Family [0.03%]
中国一个家庭的第4型眼皮肤白化病(OCA4)罕见常染色体显性遗传方式及其临床和功能特征分析
Yingzi Zhang,Teng Liu,Qingsong Yang et al.
Yingzi Zhang et al.
Oculocutaneous albinism (OCA) is a complex genetic disorder characterized by reduced or absent pigmentation in the skin, hair, and eyes. Among the eight known subtypes, OCA-4 is caused by a mutation in SLC45A2, which plays a crucial role in...
Dominant Negative Mitf Allele Impacts Melanophore and Xanthophore Development and Reveals Collaborative Interactions With Tfec in Zebrafish Chromatophore Lineages [0.03%]
优势阴性Mitf等位基因影响黑素细胞和黄体细胞的发育，并揭示了斑马鱼色素细胞谱系中与Tfec的合作相互作用
Katia G Korzeniwsky,Pietro L H de Mello,Yipeng Liang et al.
Katia G Korzeniwsky et al.
Ectothermic vertebrates exhibit a diverse array of pigment cell types-chromatophores-that provide valuable opportunities to uncover mechanisms of fate specification and how they evolve. Like melanocytes of mammals, the melanophores of teleo...
Ravi Kumar Rajan
Ravi Kumar Rajan
Over the years, the cosmetic industry has shifted its focus from synthtic to natural compounds. This change is driven not only by the safety profile of natural ingredients but also by increased consumer awareness about the products they use...
Michail Angelos Papaoikonomou,Leonidas Pavlidis,Zoi Apalla et al.
Michail Angelos Papaoikonomou et al.
This review explores the current literature on conjunctival melanoma, a rare and complex periocular neoplasm, emphasizing the absence of a standardized treatment protocol and the associated management challenges. It examines the clinical, g...
Genetic Landscape of Mucosal Melanoma: Identifying Pathogenic Germline Variants [0.03%]
黏膜黑色素瘤的遗传特征：识别致病性的种系变异
Isabella Ribaudo,Michelle Arbesman,Ying Ni et al.
Isabella Ribaudo et al.
Mucosal melanomas (MM) are rare but aggressive malignancies, comprising only 1.3% of all melanoma diagnoses, with a poor 5-year survival rate below 20%. MM lacks identifiable risk factors, presents with distinct mutational profiles, and is ...
The Skin Microbiome: A New Key Player in Melanoma, From Onset to Metastatic Stage [0.03%]
皮肤微生物群：一个新的关键参与者在黑色素瘤从发生到转移阶段中的作用
Jean-Matthieu L&#x;Orphelin,Anne Dompmartin,Brigitte Dréno
Jean-Matthieu L&#x;Orphelin
The skin microbiome plays a crucial role in maintaining skin health, defending the body against harmful pathogens, and interacting with melanoma. The composition of the skin microbiome can be affected by factors like age, gender, ethnicity,...
Cancer-Associated Fibroblast Signature Can Predict Prognosis and Therapeutic Responses in Skin Cutaneous Melanoma [0.03%]
与癌症相关的成纤维细胞标志物可以预测皮肤恶性黑色素瘤的预后和治疗反应
Yue Zheng,Weihuan Shao,Tongxin Ge et al.
Yue Zheng et al.
Skin cutaneous melanoma (SKCM) is a lethal skin cancer with a poor prognosis and limited response to immunotherapy. Cancer-associated fibroblasts (CAFs) are key contributors to tumor progression, therapy resistance, and immunosuppression. I...