Impact of Drug-Drug Interactions on Clinical Outcomes in Metastatic Melanoma Patients Treated With Combined BRAF/MEK Inhibitors: A Real-World Study [0.03%]
联合BRAF/MEK抑制剂治疗转移性黑色素瘤患者中药物相互作用对临床结局的影响：一项真实世界研究
Silvia Mezi,Andrea Botticelli,Giulia Pomati et al.
Silvia Mezi et al.
The unique pharmacokinetics of BRAF and MEK inhibitors make patients vulnerable to drug-drug interactions (DDIs), which may compromise treatment efficacy in metastatic melanoma. This study evaluates the impact of DDIs on clinical outcomes i...
Observational Study
Pigment cell & melanoma research. 2025 Jul;38(4):e70026. DOI:10.1111/pcmr.70026 2025
Alteration of Hair Melanin in Patients With Mowat-Wilson Syndrome: The Role of the ZEB2 Gene in Regulating Melanogenesis Through SLC45A2 [0.03%]
Mowat-Wilson综合征患者的头发黑素改变：ZEB2基因通过SLC45A2调节黑色素生成的作用
Mayuko Yamamoto,Hiroyuki Morisaka,Yuka Shibata et al.
Mayuko Yamamoto et al.
Mowat-Wilson syndrome (MOWS) is a congenital disease characterized by intellectual disability, delayed motor development, characteristic facial features, epilepsy, and a wide spectrum of neurocristopathies. MOWS is caused by de novo heteroz...
Comprehensive Profiling of Acral Lentiginous Melanoma Reveals Downregulated Immune Activation Compared to Cutaneous Melanoma [0.03%]
全面分析肢端雀斑样黑色素瘤发现其免疫激活下调相比于皮肤黑色素瘤
Stephanie J Wang,Joanne Xiu,Katherine M Butcher et al.
Stephanie J Wang et al.
Acral lentiginous melanoma (ALM) is a rare and insufficiently understood subtype of melanoma lacking in effective treatment options. Recent work has demonstrated that the response of ALM to immune checkpoint blockade is inferior to that of ...
Comparative Study
Pigment cell & melanoma research. 2025 May;38(3):e70027. DOI:10.1111/pcmr.70027 2025
The Function of Melanin-Based Colour Polymorphism in Cattle, Sheep and Goats [0.03%]
基于黑色素的色彩多态性在牛、羊和山羊中的功能
Venkatesh K M,Alexandre Roulin
Venkatesh K M
Natural selection has rarely promoted the evolution of colour polymorphism in wild mammals. However, it is more common in domestic mammals due to artificial selection. For this reason, domestication could provide valuable insights into the ...
Philip S Goff,Peter Budd,Darren W Logan et al.
Philip S Goff et al.
We have identified a chemically induced mouse mutation which increases the eumelanic hair pigmentation. We identify a coding mutation, A3533G, resulting in an amino acid substitution Y1133C, in the Gnas gene encoding the Gαs subunit of the...
C J Cunanan,A Amirfallah,A B Sanders et al.
C J Cunanan et al.
Uveal melanoma (UM) is an aggressive intraocular malignancy. Despite effective control of primary tumors, ~50% of UM patients develop metastases, with the liver being the predominant secondary site. BAP1 deficiency, present in ~80% of metas...
Quality Analysis of Measurement Properties of Patient-Reported Outcome Measures for Vitiligo and of the Studies Assessing Them: A Systematic Review [0.03%]
白癜疯患者报告结果测量工具的测量属性及其评估研究的质量分析系统评价
Jolien Duponselle,Sandrine Herbelet,Liesbeth Delbaere et al.
Jolien Duponselle et al.
Evaluating measurement properties (MPs) of Patient Reported Outcome Measures (PROMs) in vitiligo is essential for evidence-based recommendations and identifying research gaps. This study assesses the quality of PROMs used in vitiligo. A sys...
Nelson Lobos-Guede,Dan Hartmann,Valentina Darlic et al.
Nelson Lobos-Guede et al.
Melanomas can appear de novo or in association with a pre-existing nevus. The association of melanomas with pre-existing nevi and its role as a melanoma precursor is a controversial issue. Dermoscopy can increase melanoma's diagnostic accur...
Neurological Mechanisms Exploration and Therapeutic Targets in Segmental Vitiligo Accompanied by White Hair [0.03%]
节段型白癜伴白发的神经机制探索及治疗靶点研究
Shiqi Fu,Bo Xie,Xiuzu Song
Shiqi Fu
Vitiligo is the most common skin depigmentation disease, affecting 0.1%-2% of people in the world. 3.5%-20.5% of segmental patients account for the total number of vitiligo patients. It has been clinically observed that segmental vitiligo p...
PURPL Represses Radiation-Induced Apoptosis to Promote Radioresistance in Cutaneous Melanoma by Direct Interfering With BID Cleavage [0.03%]
PURPL通过直接干扰BID切割来抑制放射诱导的细胞凋亡从而促进皮肤黑色素瘤放疗抵抗作用
Xue Li,Shuo Han,Xiaoting Liang et al.
Xue Li et al.
The rise of radioresistance in treating cutaneous melanoma challenges the efficacy of radiotherapy. Transcriptomic sequencing highlights PURPL as one of the top upregulated long noncoding RNAs in response to ionizing radiation (IR) treatmen...