Pigmentation and Retinal Pigment Epithelium Thickness: A Study of the Phenotypic and Genotypic Relationships Between Ocular and Extraocular Pigmented Tissues [0.03%]
色素与视网膜色素上皮厚度：眼部和眼外色素组织表型和基因型关系的研究
Thomas H Julian,Tomas Fitzgerald;UK Biobank Eye and Vision Consortium;Ewan Birney,Panagiotis I Sergouniotis
Thomas H Julian
The retinal pigment epithelium (RPE) is a specialised monolayer of pigmented epithelial cells in the outer retina. The extent to which RPE pigmentation is related to that of other tissues remains unclear. We utilised RPE thickness measured ...
Kazunori Yokoi,Yosuke Ishitsuka,Kanae Kusao et al.
Kazunori Yokoi et al.
Vitiligo is a common depigmentation disorder characterized by patchy white macules. It has been reported that vitiligo lesions, particularly in exposed areas, such as the face and hands, cause severe psychological distress. Although the cla...
PRMT6 Inhibits Malignant Progression of Melanoma by Antagonizing Trimethylation of Histone H3K4 to Downregulate ALDH1A1 Levels [0.03%]
脯氨酰-tRNA合成酶互作蛋白6通过拮抗组蛋白H3K4甲基化抑制醛脱氢酶1A1表达并阻抑黑色素瘤恶性进展
Man Cai,Liangyu Wang,Miao Sun et al.
Man Cai et al.
Protein arginine methyltransferase 6 (PRMT6), a member of the PRMT family capable of self-arginine methylation, is down-regulated in melanoma, but the specific mechanism is still unclear. Our work demonstrated that PRMT6 overexpression sign...
YAP Upregulation Contributes to Acquired Resistance to BET Inhibitors in Uveal Melanoma [0.03%]
YAP上调对眼黑色素瘤获得性抵抗BET抑制剂的影响
Yan-Ling Zhou,Xiao-Lian Liu,Si-Si Huang et al.
Yan-Ling Zhou et al.
BET inhibitors have the potential to treat malignant tumors via the epigenetic modification mechanism. Although BET inhibitors show promise as anticancer agents for uveal melanoma (UM), the emergence of acquired resistance significantly lim...
Prospective Isolation According to Melanin Pigment Content of Melanoma Cells With Heterogeneous Potentials for Disease Propagation [0.03%]
根据黑色素 pigment含量对未来黑色素瘤细胞进行异质疾病传播潜能的分离隔离研究
Clare Fedele,Gamze Kuser-Abali,Ralph Rossi et al.
Clare Fedele et al.
Intra-tumoral heterogeneity poses a major challenge to treating and managing cancer patients. A characteristic feature of melanoma is its composition of cancer cells with typically heterogeneous content of melanin pigment, the production of...
Immunotherapy Rechallenge Is Effective for Most Patients With Late Progression After Initial Ipilimumab + Nivolumab Response [0.03%]
大多数使用伊匹单抗+纳武利尤单抗初始治疗后晚期复发的患者再次接受免疫治疗有效
Ethan Trim,Anita Giobbie-Hurder,Tamara A Sussman et al.
Ethan Trim et al.
Clinical benefit achieved with ipilimumab + nivolumab combination therapy is typically long lasting. However, late progression, after therapy completion, does occur in a subset of patients. At the time of late progression, immunotherapy opt...
Lanxin Li,Jixuan Huang,Yonglong Chen et al.
Lanxin Li et al.
The melanocortin 1 receptor (MC1R) is well-established as a pivotal regulator of pigmentation in various species. Despite a wealth of research focused on mammals and fish, the role of Mc1r in amphibians has remained largely unexplored. This...
SASH1 Mutations and Hereditary Disorders of Pigmentation: Review of Literature [0.03%]
SASH1基因突变与色素遗传病的研究进展回顾
Anuradha Bishnoi,Aarushi Arunima,Keshavamurthy Vinay et al.
Anuradha Bishnoi et al.
Dyschromatosis universalis hereditaria (DUH) is a rare genodermatosis characterized by asymptomatic hyper- and hypopigmented macules appearing in infancy and persisting for life. Although mutations in ABCB6 account for many DUH cases, recen...
Wei Liu,Wanlu Ma,Xiao Xue et al.
Wei Liu et al.
Vitiligo is an acquired depigmentation disorder characterized by the loss of melanocytes. The specific etiology of vitiligo is not fully understood, but it is thought to result from a complex interplay of factors, including autoimmune respo...
Microfluidic Characterization and Analysis of Circulating Tumor Cells From Patients With Metastatic Melanoma [0.03%]
来自晚期黑色素瘤患者循环肿瘤细胞的微流体分析与鉴定
Matthew C Mannino,Shuang G Zhao,Benjamin K Gibbs et al.
Matthew C Mannino et al.
Circulating tumor cells (CTCs) can provide non-invasive insight into how a cancer patient responds to therapy. Their role in disease monitoring of advanced melanoma patients treated with immune checkpoint inhibitors (ICI) is unknown. CTC pr...