Germline MC1R Variant Status and Efficacy of Immune Checkpoint Inhibitors in Patients With Advanced Melanoma [0.03%]
黑色素瘤患者生殖细胞MC1R基因变异状态与免疫检查点抑制剂疗效的相关性研究
Muyi Yang,Suzanne Egyhazi Brage,Jan Lapins et al.
Muyi Yang et al.
The melanocortin-1-receptor (MC1R) has a key role in melanocyte pigmentation regulation. Certain MC1R germline genetic variants (R alleles) result in deficient melanin production and are associated with red hair, freckling, UV sensitivity, ...
LRP2 Expression in Melanoma Is Associated With a Transitory Cell State, Increased T Cell Infiltration, and Is Upregulated by IFNy Signaling [0.03%]
LRP2在黑色素瘤中的表达与转瞬即逝的细胞状态、增加的T细胞浸润以及由IFNy信号调节的上调有关
Martin Q Rasmussen,Marie L Bønnelykke-Behrndtz,Camilla Merrild et al.
Martin Q Rasmussen et al.
Low density lipoprotein receptor-related protein 2 (LRP2) is a 600 kilodalton multi-ligand endocytic membrane receptor expressed in several cell types during fetal development, including neuroepithelial cells, and in select absorptive epith...
Rapid Diagnosis and Subtyping of Hermansky-Pudlak Syndrome With Flow Cytometry Analysis [0.03%]
采用流式细胞术分析技术快速诊断和分类白化-出血综合征
Yingzi Zhang,Teng Liu,Qingsong Yang et al.
Yingzi Zhang et al.
The diagnostic approaches for Hermansky-Pudlak Syndrome (HPS) include genetic sequencing, immunoblotting, electron microscopy (EM), and flow cytometry with mepacrine staining. However, these methods are often impractical for routine clinica...
Treatment of Acquired Dermal Macular Hyperpigmentation With Oral Isotretinoin: A Multi-Institutional Retrospective Study of 121 Cases [0.03%]
口服异维A酸治疗获得性皮肤色素沉着病的疗效与安全性：多中心回顾性研究
Zhongyi Xu,Yuecen Ding,Chengfeng Zhang et al.
Zhongyi Xu et al.
The term acquired dermal macular hyperpigmentation (ADMH) was introduced to unify Riehl's melanosis (RM), lichen planus pigmentosus (LPP), and related entities. These are cosmetically distressing pigmentary disorders that pose therapeutic c...
Multicenter Study
Pigment cell & melanoma research. 2025 Sep;38(5):e70052. DOI:10.1111/pcmr.70052 2025
Many Faces of Melanoma: A Comparison Between Cutaneous, Mucosal, Acral, Nail, and Ocular Malignancy [0.03%]
melanoma的多种面——皮肤、粘膜、肢端、甲板和眼恶性黑色素瘤的对比分析
Julia Nowowiejska,Agata Joanna Ordon,Piotr Purpurowicz et al.
Julia Nowowiejska et al.
A melanoma is a malignant neoplasm that originates from melanocytes. Melanocytes are found in various body sites-they are most commonly found in the skin (including acral sites and nail units), ocular structures, and mucosal membranes. This...
Development and Validation of Vitiligo-Specific-Belief About Therapy Questionnaire (BTQ-Vitiligo) [0.03%]
白癜疯特异性治疗信念问卷(BTQ-白癜风)的编制和验证
Sree Yazhini Ramar,Sivaranjini Ramassamy,Malathi Munisamy et al.
Sree Yazhini Ramar et al.
There is a need to capture therapy-related beliefs held by patients with conditions like vitiligo that have complex treatment regimens. Concerns about adverse effects and uncertainty about response to the prescribed treatment can impact adh...
Prognostic and Predictive Value of ctDNA for Metastatic Uveal Melanoma: A Systematic Review and Meta-Analysis [0.03%]
ctDNA对转移性脉络膜黑色素瘤的预后和预测价值：系统评价和meta分析
Mariana Macambira Noronha,Luís Felipe Leite da Silva,Luiz Felipe Costa Almeida et al.
Mariana Macambira Noronha et al.
Metastatic uveal melanoma (mUM) is a rare disease associated with poor prognosis and limited therapeutic options. Recent studies showed that detecting ctDNA is feasible and can aid treatment decisions for patients with mUM. We systematicall...
Clinical Prognostic Factors Predicting Outcomes in Vitiligo: A Scoping Review [0.03%]
银屑病临床预后因素的综述研究
Lipsa Kumari,Nikhil Mehta,Shivam Pandey et al.
Lipsa Kumari et al.
The progression of non-segmental vitiligo is highly unpredictable, exhibiting various phenotypes that can range from rapid progression to stability. Due to limited literature, we conducted a scoping review to identify factors influencing th...
Association of Pretreatment Tumour Microenvironment and Treatment Outcome in Patients With Locally Advanced Melanoma Treated With Isolated Limb Perfusion [0.03%]
局部晚期黑色素瘤患者孤立肢体灌注治疗的预处理肿瘤微环境与治疗结局之间的关系
Sanni K A Tulokas,Susanna Juteau,Siru P Mäkelä et al.
Sanni K A Tulokas et al.
As effective melanoma treatments have become available, utilizing isolated limb perfusion (ILP) to treat unresectable melanoma limited to the limb has decreased. However, some patients still receive long-term benefits from ILP. We aimed to ...