Excimer 308-Nm Light in the Combination Treatment of Vitiligo: A Systematic Review and Network Meta-Analysis [0.03%]
эксимер308-nm光联合治疗白癜风：系统评价与网络Meta分析
Zhengyang Liu,Wey Han Ng,Samuel Morriss et al.
Zhengyang Liu et al.
Excimer 308-nm light is often used for vitiligo treatment in combination with adjuvants. We aimed to evaluate the efficacy of these combination therapies. We searched MEDLINE, Embase and the Cochrane Library from inception to November 2024....
First Report of Oculocutaneous Albinism Type I Among Baka Pygmies From Cameroon [0.03%]
喀麦隆巴卡俾格米人中第一例眼皮肤白化病1型报告
Alain Froment,Paul Verdu,Claudio Plaisant et al.
Alain Froment et al.
Oculocutaneous albinism type 1 (OCA1) caused by pathogenic variants of the TYR gene is an autosomal recessive disorder of pigmentation characterized by reduced biosynthesis of melanin pigment in skin, hair, and eyes. We had the opportunity ...
Chicken Shank Color Determined by Inhibition of Dermal Melanin (ID) is Mediated by a Structural Variation Regulating CDKN2A Expression [0.03%]
鸡爪皮色由抑制真皮黑色素(ID)介导的CDKN2A表达调控结构变异决定
Jingyi Li,Lei Wang,Sendong Yang et al.
Jingyi Li et al.
Shank color in chickens is a classic quantitative trait governed by four genetic loci. Among these, the Inhibition of dermal melanin (ID) locus, which suppresses dermal melanogenesis in the shank, is the sole sex-linked mutation and its mol...
Comparative Efficacy of Cryosurgery Versus Alternative Techniques for Intraoral Depigmentation: A Systematic Review and Meta-Analysis [0.03%]
用于口腔内脱色的冷冻手术与替代技术的比较疗效：系统评价和meta分析
Shiva Shirazian,Mehdi Vatanpour,Maryam Tahmasebinasab
Shiva Shirazian
Various factors influence the color of the gingiva, and physiological gingiva pigmentation can affect self-image without causing systemic issues. This study aimed to systematically review all articles that compare the effectiveness of cryos...
Melanomas and Mesenchymal Tumors Arising in Giant Congenital Melanocytic Nevi: Clinico-Pathological and Molecular Characterization of a Case Series [0.03%]
巨大先天性黑素细胞痣源发恶性黑色素瘤和肉瘤的临床病理及分子特征分析
Sabrina Rossi,Sabina Barresi,Isabella Giovannoni et al.
Sabrina Rossi et al.
Giant congenital melanocytic nevi (GCMN) are benign mosaic disorders that may give rise to various tumor types through incompletely understood mechanisms. We characterized a series of two melanomas and four mesenchymal tumors (two embryonal...
Genetic Features of Albinism: A Comprehensive Analysis in the Russian Population [0.03%]
俄罗斯人群中的白化病的遗传特征综合分析研究
Sofya Ionova,Andrey Marakhonov,Vitaliy Kadyshev et al.
Sofya Ionova et al.
We present a comprehensive molecular and epidemiological analysis of albinism in a Russian cohort, comprising 177 probands with isolated (OCA1, OCA2, OCA3, OCA4, and OA) and syndromic (HPS-associated) forms of the disease. The comparative a...
Updated Analysis of Albinism in Japan: 290 Families With Novel Pathological Variants [0.03%]
日本白化病的更新分析：290个家系中的新型致病变异
Ken Okamura,Toru Saito,Naoki Oiso et al.
Ken Okamura et al.
We present an updated analysis of albinism in Japan, encompassing both oculocutaneous albinism (OCA) and ocular albinism (OA), based on 290 families, which expands our previous study by 100 additional families. The overall frequency distrib...
SASH1 Modulates Melanin Synthesis and Melanoma Cell Metastasis via Suppression of the TGF-β Signaling Pathway [0.03%]
SASH1通过抑制TGF-β信号通路调节黑色素合成和黑色素瘤细胞转移
Hongzhou Cui,Jianhua Hao,Qiong Wang et al.
Hongzhou Cui et al.
Dyschromatosis universalis hereditaria (DUH) is characterized by autosomal dominant inheritance and widespread involvement of hyperpigmentation and depigmentation. In our previous study, we identified mutations in the SH3 domain-containing ...
PD-1/PD-L1 Checkpoint Dysfunction in Vitiligo: Novel Pathogenic Insights and Therapeutic Innovation [0.03%]
白癜风中PD-1 / PD-L1检查点功能障碍：新的病理学见解和治疗创新
Heba Ahmed,Hanan R Nada,Ahmed Mourad et al.
Heba Ahmed et al.
Vitiligo, a chronic autoimmune disorder characterized by progressive melanocyte destruction, remains challenging to treat due to an incomplete understanding of underlying immune mechanisms. Recent clinical observations from cancer immunothe...
Combination of the Novel RAF Dimer Inhibitor Brimarafenib With the MEK Inhibitor Mirdametinib Is Effective Against NRAS Mutant Melanoma [0.03%]
新型RAF二聚体抑制剂Brimarafenib与MEK抑制剂Mirdametinib联合用药对NRAS突变黑色素瘤有效
Flavia L Tellenbach,Luzia Seiler,Mark Johnson et al.
Flavia L Tellenbach et al.
Metastatic melanoma, the most aggressive form of skin cancer, accounts for the majority of skin cancer-related deaths. While targeted kinase inhibitors have improved outcomes for patients with BRAF-mutated melanomas, their efficacy is often...