Lluís Montoliu,Karen Grønskov,Ai-Hua Wei et al.
Lluís Montoliu et al.
Albinism is a rare genetic condition globally characterized by a number of specific deficits in the visual system, resulting in poor vision, in association with a variable hypopigmentation phenotype. This lack or reduction in pigment might ...
Clonal growth of human melanocytes using cell-free extracellular matrix [0.03%]
无细胞基质培养黑色素细胞的克隆生长能力研究
Rong Zhang,Sanjay Premi,Sarah S Kilic et al.
Rong Zhang et al.
Identification of glycogen synthase kinase 3α as a therapeutic target in melanoma [0.03%]
识别糖原合成酶激酶3α作为治疗黑色素瘤的靶点
SubbaRao V Madhunapantula,Arati Sharma,Raghavendra Gowda et al.
SubbaRao V Madhunapantula et al.
Deregulated expression or activity of kinases can lead to melanomas, but often the particular kinase isoform causing the effect is not well established, making identification and validation of different isoforms regulating disease developme...
Essential role of the molecular chaperone gp96 in regulating melanogenesis [0.03%]
分子伴侣gp96在黑色素生成调控中的重要作用
Yongliang Zhang,Kristi L Helke,Sergio G Coelho et al.
Yongliang Zhang et al.
Through a process known as melanogenesis, melanocyte produces melanin in specialized organelles termed melanosomes, which regulates pigmentation of the skin, eyes, and hair. Gp96 is a constitutively expressed heat shock protein in the endop...
A melanoma immune response signature including Human Leukocyte Antigen-E [0.03%]
包括人类白细胞抗原-E的黑色素瘤免疫反应特征签名
Elisa Tremante,Agnese Ginebri,Elisa Lo Monaco et al.
Elisa Tremante et al.
Paired cultures of early-passage melanoma cells and melanocytes were established from metastatic lesions and the uninvolved skin of five patients. In this stringent autologous setting, cDNA profiling was used to analyze a subset of 1477 gen...
Clinical Trial
Pigment cell & melanoma research. 2014 Jan;27(1):103-12. DOI:10.1111/pcmr.12164 2014
Alessandro Mongera,Christopher M Dooley
Alessandro Mongera
James A Lister
James A Lister
Hadas Prag Naveh,Uma N M Rao,Lisa H Butterfield
Hadas Prag Naveh
Melanoma is an 'immunogenic tumor', often highly infiltrated with lymphocytes, which are capable of inducing regression of the primary tumor. The commonly observed phenomenon of regression suggests substantial cross-talk between immune cell...