Association Between Melanoma Metastasis and Metabolic Syndrome: A Cross-Sectional Study in a Chinese Population [0.03%]
中国人群黑色素瘤转移与代谢综合征的关联：一项横断面研究
Shanshan Sha,Shuomin Sun,Liyun Dong et al.
Shanshan Sha et al.
Metabolic syndrome (MetS) remains a significant global public health concern. However, the relationship between MetS, its individual components and melanoma metastasis remains unexplored. We analysed the clinical data of 258 Chinese melanom...
Curation of OCA2 Variants of Uncertain Significance From Chinese Oculocutaneous Albinism Patients Based on Multiplex Assays [0.03%]
基于多重检测的中国眼皮肤白化病患者OCA2变异位点的筛选及功能研究
Qingsong Yang,Yizhen Wang,Zengge Wang et al.
Qingsong Yang et al.
Oculocutaneous albinism type 2 (OCA-2, OMIM: 203200) is associated with variants in the OCA2 gene. In this study, we aimed to re-classify variants of uncertain significance (VUS) in OCA2 by evaluating subcellular localization and channel ac...
Stanislau Makaranka,Zon Oo,Jonathan Pollock
Stanislau Makaranka
Current NICE guidelines state that in high-risk melanoma patients, imaging should not be offered before SLNB unless lymph node or distant metastases are suspected. Our experience has been that in patients with pT3b, pT4a and pT4b melanomas,...
Mouse Tail-Skin Dissociation and Preparation of Live Single-Cell Suspension for Downstream Analysis of Melanocytes [0.03%]
小鼠尾部皮肤分离及黑素细胞下游分析的单细胞悬液制备
Vipin Shankar Chelakkot,Kiara Thomas,Leen Hussein et al.
Vipin Shankar Chelakkot et al.
Isolating high-quality viable single cells from mouse tail skin, a well-established model for studying skin cells and melanoma pathogenesis, is challenging due to the presence of dense connective tissue and hair follicles. Single-cell RNA s...
A Ball Python Colour Morph Implicates MC1R in Melanophore-Xanthophore Distribution and Pattern Formation [0.03%]
一个新的boa constrictor品种的颜色变异暗示了MC1R在色素细胞分布和颜色形成中的作用
Alan Garcia-Elfring,Heather L Roffey,Jaren M Abergas et al.
Alan Garcia-Elfring et al.
Reptiles showcase an extensive array of skin colours and patterns, yet little is known about the genetics of reptile colouration. Here, we investigate the genetic basis of the Clown colour morph found in captive-bred ball pythons (Python re...
Novel Variants in Medium and Low Penetrance Predisposing Genes in a Hungarian Malignant Melanoma Cohort With Increased Risk [0.03%]
在匈牙利恶性黑色素瘤高风险队列中增加风险的中度和低度 penetrance 倾向基因的新变异体
Barbara Anna Bokor,Aliasgari Abdolreza,Flóra Kaptás et al.
Barbara Anna Bokor et al.
Both germline and somatic variants contribute to the genetic background and pathogenesis of melanoma. Germline variants include the presence of rare pathogenic or likely pathogenic variants of high, medium, and low penetrance melanoma-predi...
Exploring the Common Mutational Landscape in Cutaneous Melanoma and Pancreatic Cancer [0.03%]
探索皮肤黑色素瘤和胰腺癌中共有的基因突变图谱
Elisabetta Broseghini,Federico Venturi,Giulia Veronesi et al.
Elisabetta Broseghini et al.
Cutaneous melanoma (CM) and pancreatic cancer are aggressive tumors whose incidences are rapidly increasing in the last years. This review aims to provide a complete and update description about mutational landscape in CM and pancreatic can...
Eleanor Johns,Yilun Ma,Pakavarin Louphrasitthiphol et al.
Eleanor Johns et al.
Lipid droplets are fat storage organelles composed of a protein envelope and lipid-rich core. Regulation of this protein envelope underlies differential lipid droplet formation and function. In melanoma, lipid droplet formation has been lin...
UVA Irradiation Promotes Melanoma Cell Proliferation Mediated by OPN3 Independently of ROS Production [0.03%]
紫外线辐射通过独立于ROS产生的OPN3促进黑色素瘤细胞增殖
Yulei Zhang,Wen Zeng,Wei Zhang et al.
Yulei Zhang et al.
UVA radiation, a primary risk factor in melanoma progression, partly acts through the mediation of reactive oxygen species (ROS). The role of ROS in driving cutaneous melanoma toward an invasive phenotype and whether it occurs through opsin...
Bay 11-7082, an NF-κB Inhibitor, Prevents Post-Inflammatory Hyperpigmentation Through Inhibition of Inflammation and Melanogenesis [0.03%]
抑炎和减黑作用的NF-κB抑制剂贝酸酯可预防炎症后色素沉着过度现象
Juwon Moon,Ik Jun Moon,Hoyong Hyun et al.
Juwon Moon et al.
Post-inflammatory hyperpigmentation (PIH) is a very common disorder of cutaneous hyperpigmentation, which poses a persistent management challenge in the fields of dermatology and esthetics. This study was designed to explore the anti-melano...