Tumor suppressive activities of the cohesin SA1/STAG2 and effects of PARP impairment during Drosophila brain development [0.03%]
SA1/STAG2共hesion的肿瘤抑制活性以及PARP在果蝇大脑发育过程中的影响作用
Simona Totaro,Antonella Lettieri,Silvia Castiglioni et al.
Simona Totaro et al.
The cohesin complex performs essential cellular functions including regulation of chromatin organization and DNA repair. Somatic pathogenetic variants in cohesin genes, such as STAG2, have been associated with cancer, but their contribution...
Disease Models & Mechanisms: a short history of supporting early-career researchers [0.03%]
疾病模型及机制：支持早期职业研究人员的简短历史
Rachel Hackett
Rachel Hackett
The scope of Disease Models & Mechanisms (DMM) encompasses different communities - clinicians, basic researchers, translational scientists, patients and their advocates and families, as well as many different disease areas and model systems...
Tamoxifen treatment fails to improve muscle dysfunction in a model of recessive RYR1-linked centronuclear myopathy [0.03%]
他莫昔芬治疗未能改善遗传性RYR1连接中心核肌病模型中的肌肉功能障碍
Charlotte Gineste,David Reiss,Jocelyn Laporte
Charlotte Gineste
Centronuclear myopathies (CNMs) are rare congenital muscle disorders with no effective treatment. Previous studies showed that tamoxifen improved muscle function in mice modeling CNMs caused by variants in MTM1, BIN1 and DNM2. Here, we inve...
O Claire Moulton,Saanjbati Adhikari,Rachel Hackett et al.
O Claire Moulton et al.
Serge Mostowy,Katherine R Duncan
Serge Mostowy
Stem cells and ageing in the blood: an interview with Margaret (Peggy) Goodell [0.03%]
干细胞与血液衰老：Margaret(Peggy)Goodell博士访谈记
Margaret Peggy Goodell
Margaret Peggy Goodell
Margaret (Peggy) Goodell has significantly advanced our understanding of haematopoietic stem cells - the stem cells that develop into different types of specialised blood cells. She is Professor and Chair of the Department of Molecular and ...
Compound design of a patient-derived 3D cell culture system modelling early peritoneal endometriosis [0.03%]
基于患者衍生的三维细胞培养系统的早期盆腔内异症构建及设计
Muhammad D R Rahmana,Christopher J Hill,Bettina Wilm et al.
Muhammad D R Rahmana et al.
Peritoneal endometriosis causes pelvic pain and infertility, but the underlying mechanisms related to these symptoms are not fully understood. Endometriosis diagnosis is typically delayed; thus, patient samples are unsuitable to study early...
A novel Lafora disease astrocytic cellular model to study polyglucosan accumulation and inflammation [0.03%]
一种新颖的拉福尔病星形胶质细胞模型用于研究多糖链累积和炎症反应
M Moreno-Estellés,A Campos-Rodríguez,R Viana et al.
M Moreno-Estellés et al.
Lafora disease (LD) is a devastating form of progressive myoclonus epilepsy characterized by the accumulation of insoluble forms of glycogen (polyglucosans, PGBs) in the brain and peripheral tissues. It has been proposed that the accumulati...
Rebekah Niewoehner,David Paulding,Jesus M Leal et al.
Rebekah Niewoehner et al.
Primary cilia play a pivotal role in cellular signaling and development. Human primary microcephaly is strongly associated with pathogenic variants in primary cilia genes. Here, we examine the role of Ttc21b, a component of the intraflagell...
Osteocyte lacunar:vascular microarchitecture is spatially heterogenous and VEGF dependent in male murine bone [0.03%]
雄性小鼠骨组织中骨细胞腔隙：血管微型结构的分布是空间异质性的且依赖于VEGF
Jacob Trend,Jacob Keen,Aikta Sharma et al.
Jacob Trend et al.
Cortical bone is highly porous comprising of interconnecting network of vascular canals and osteocyte lacunae. Our understanding of the mechanisms coupling vascular: lacunar spatial organisation in cortical bone is poorly understood. Defini...