BMP-dependent mobilization of fatty acid metabolism promotes Caenorhabditis elegans survival on a bacterial pathogen [0.03%]
依赖BMP调动脂肪酸代谢促进芽孢杆菌病原体上的秀丽隐杆线虫存活
Katerina K Yamamoto,Margaret Wan,Rijul S Penkar et al.
Katerina K Yamamoto et al.
The Bone Morphogenetic Proteins (BMPs) are secreted peptide ligands of the Transforming Growth Factor beta (TGF-β) family, initially identified for their roles in development and differentiation across animal species. They are now increasi...
The transcriptome and secreted factors of the intervertebral discs in STZ-HFD Type 2 diabetic male mice reveal extensive inflammation [0.03%]
链脲佐菌素高脂饮食型2型糖尿病小鼠椎间盘的转录组和分泌蛋白揭示了广泛的炎症反应
Christian E Gonzalez,Rachana S Vaidya,Sade W Clayton et al.
Christian E Gonzalez et al.
The chronic inflammation observed during type 2 diabetes (T2D) is associated with spinal pathologies, including intervertebral disc (IVD) degeneration and chronic spine pain. Despite the presence of confounding factors, such as obesity, stu...
14-3-3θ Phosphorylation at S232 reduces its interactome and regulates axonal trafficking [0.03%]
S232磷酸化通过减少14-3-3θ的互作蛋白来调节轴突转运功能
F Sanders Pair,Rudradip Pattanayak,James A Mobley et al.
F Sanders Pair et al.
14-3-3 proteins impact protein-protein interactions (PPIs) that regulate neuronal functions. The 14-3-3θ isoform is protective in Parkinson's disease (PD) and Dementia with Lewy Bodies (DLB) models. Human PD and DLB brains show increased 1...
Kandas Traore,Damien Seyer,Agnes Mihajlovski et al.
Kandas Traore et al.
Antimicrobial resistance represents one of the most serious threats to both public health and economic sustainability. One of the promising approaches to address this problem is phage therapy - treatment of pathogenic bacterial infections u...
Noncoding and coding mechanisms of aging heart failure with preserved ejection fraction with thyroid dysfunction [0.03%]
甲状腺功能不全的心力衰竭患者（射血分数保留）的非编码和编码衰老机制
Sankalpa Chakraborty,Olivia Sloan,Bryce Dickerson et al.
Sankalpa Chakraborty et al.
Heart Failure with preserved Ejection Fraction (HFpEF) is a lethal, heterogeneous, geriatric syndrome. Long noncoding RNAs (lncRNAs) constitute the majority of the functional mammalian transcriptome and are key regulators in complex pathoph...
Robin A Karge,Florian P Fischer,Hannah Schüth et al.
Robin A Karge et al.
Genetic defects in AP2M1, which encodes the μ-subunit of the adaptor protein complex 2 (AP-2) essential for clathrin-mediated endocytosis (CME), cause a rare form of developmental and epileptic encephalopathy (DEE). In this study, we model...
Validation of a rheumatoid arthritis mouse model that uses NOD-scid IL2Rγnull mice reconstituted with patient PBMCs [0.03%]
验证使用NOD-scid IL2Rγ小鼠重建患者PBMCs的类风湿关节炎小鼠模型
Paula Schuster-Winkelmann,Veronika Weß,Marietta Schindler et al.
Paula Schuster-Winkelmann et al.
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by inflammation and joint destruction. Replicating human manifestations of RA in animal models remains challenging, however, due to heterogeneity of the disease. In thi...
FAK modulates glioblastoma stem cell energetics via regulation of glycolysis and glutamine oxidation [0.03%]
FAK通过调节糖酵解和谷氨酰胺氧化调控胶质母细胞瘤干细胞代谢
Roza H A Masalmeh,John C Dawson,Virginia Alvarez Garcia et al.
Roza H A Masalmeh et al.
Glycolysis and the TCA cycle are reprogrammed in cancer cells to meet bioenergetic and biosynthetic demands, including by engagement with the extracellular matrix (ECM). However, the mechanisms by which the ECM engagement reprograms core en...
Unravelling γδ T-cell dysregulation in the gut and its implications for immune-mediated diseases [0.03%]
肠道γδ T细胞功能失调与自身免疫性疾病的关系解析研究
Dilys Santillo,Evangelos Bellos,Vanessa Sancho-Shimizu
Dilys Santillo
Multisystem inflammatory syndrome in children (MIS-C) is a rare condition associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and characterised by systemic inflammation and T-cell dysfunction. A subset of ...
Expanding and refining the mammalian phenotype ontology to enhance disease model discovery [0.03%]
扩展和精炼哺乳动物表型本体以增强疾病模型发现
Susan M Bello,Anna V Anagnostopoulos,Leigh C Carmody et al.
Susan M Bello et al.
The mouse is a premier model system for investigating gene function and modeling human disease. For almost 40 years, Mouse Genome Informatics has worked to capture and integrate the data generated from mouse studies. A critical component of...