Esther B E Becker,Simone Mayer,Lena M Kutscher
Esther B E Becker
Cerebellar organoids present promising tools for the modelling of human cerebellar development and diseases. As this young field grows, robust standards and transparent reporting practices are needed to ensure the reproducibility and utilit...
Inhibition of Cxcr4 chemokine receptor signaling improves habituation learning in a zebrafish model of Neurofibromatosis [0.03%]
Cxcr4化学因子受体信号转导的抑制可改善结节性硬化症斑马鱼模型中的习惯学习能力
Andrew H Miller,Yeng Yang,Natalie Schmidt et al.
Andrew H Miller et al.
Neurofibromatosis type 1 (NF1) is a neurogenetic disorder caused by loss of function mutations in the gene neurofibromin 1 (NF1). NF1 encodes neurofibromin, a multifunctional tumor suppressing protein that regulates Ras, cAMP, and dopamine ...
Enhanced lysosomal exocytosis and altered growth factor signaling are associated with cartilage pathology in a zebrafish model of MPSIVA [0.03%]
MPSIVA斑马鱼模型中增强的溶酶体胞吐作用和生长因子信号转导改变与软骨病理相关
Jen-Jie Lee,Po-Nien Lu,Lynn Dukes-Rimsky et al.
Jen-Jie Lee et al.
Optimal lysosomal function is essential for early tissue development. This is evidenced by the large number of inherited disorders, collectively called the lysosomal storage disorders (LSDs), caused by lysosomal dysfunction. While it is cle...
microRNA-21 promotes dysregulated lipid metabolism and hepatocellular carcinoma [0.03%]
微小核糖核酸-21促进脂质代谢失调和肝细胞癌发生发展
Chad VanSant-Webb,Jessye C Castro,Audrey Y Su et al.
Chad VanSant-Webb et al.
The prevalence of hepatocellular carcinoma (HCC) is rising in parallel with increasing obesity and metabolic dysfunction-associated steatohepatitis (MASH). MicroRNAs are key post-transcriptional regulators of gene expression and are attract...
A segment anything model-based tool for semi-automated behavioural analysis of Drosophila and other model organisms [0.03%]
一种基于模型的半自动行为分析工具，用于果蝇和其他模式生物
Sarah Mele,Joshua Millward,Long Nguyen et al.
Sarah Mele et al.
Quantitative behavioural analysis is a powerful approach for linking genotype to phenotype, but many existing tools require specialised hardware, extensive preprocessing, or coding expertise. We present SAMBA (Segment Anything Model for Beh...
Immunopathological outcomes are isolate-dependent in chronic Mycobacterium avium complex pulmonary disease [0.03%]
慢性马尔尼菲青霉菌肺病的免疫病理结果取决于分离系
T D Shaw,H Lam,T S Dutt et al.
T D Shaw et al.
Novel treatment strategies are urgently needed to combat Mycobacterium avium complex pulmonary disease (MAC-PD). Animal models are important for screening therapeutic strategies, but their ability to reproduce human-like immunopathology, an...
Generation and characterization of a Cre-Inducible MAP3K1 Gain-of-Function Model [0.03%]
可控MAP3K1基因活化的转基因小鼠模型及其表型分析
Bo Xiao,Maureen Mongan,Chia I Ko et al.
Bo Xiao et al.
MAP3K1 is a multifunctional signaling kinase implicated in diverse biological processes. Although its Gain-of-Function (GoF) mutations contribute to multiple human diseases, including 46,XY disorders of sex development (DSDs), mechanistic s...
Small molecule screen identifies elafibranor to link mechanical cues and IRF6-dependent epithelial differentiation [0.03%]
小分子筛选鉴定出elafibranor连接力学刺激与IRF6依赖的上皮细胞分化
Helen L Molteni,Brandi Golden,Emily P Y Yu et al.
Helen L Molteni et al.
The periderm is a transient epithelial layer with crucial roles in maintaining barrier integrity and preventing abnormal adhesions during midface development. Interferon regulatory factor 6 (IRF6) is a key genetic driver of periderm functio...
Transcriptomic landscape identifies C-C motif receptor 2 as a core pro-fibrotic factor in uremic cardiomyopathy [0.03%]
转录组学特征确定C-C基序受体2是尿毒症心肌病的核心促纤维化因子
Jing-Fu Bao,Bao-Cheng Guo,Jia-Ju Mo et al.
Jing-Fu Bao et al.
Uremic cardiomyopathy (UC) represents a leading cause of mortality in patients with chronic kidney disease (CKD), characterized by left ventricular hypertrophy (LVH) and fibrosis. The underlying mechanisms of UC pathogenesis remain incomple...
A new dystrophin deficient rat model mirroring exon skipping in patients with DMD exon 45 deletions [0.03%]
一个全新的dmd exon45缺失患者的外显子跳过现象的营养不良蛋白缺乏大鼠模型
Tao Wang,Cynthia Daoud,Auriane Dubois et al.
Tao Wang et al.
Pathogenic variants in the dystrophin (DMD) gene cause muscle-wasting disorders ranging from the milder Becker muscular dystrophy (BMD) to the more severe Duchenne muscular dystrophy (DMD). Exon 45 deletion is the most frequent single-exon ...