Pathological evaluation of rats carrying in-frame mutations in the dystrophin gene: a new model of Becker muscular dystrophy [0.03%]
携带肌营养不良基因内框突变的实验大鼠的病理评估：一种新的贝克氏肌肉萎缩症模型
Naomi Teramoto,Hidetoshi Sugihara,Keitaro Yamanouchi et al.
Naomi Teramoto et al.
Dystrophin, encoded by the DMD gene on the X chromosome, stabilizes the sarcolemma by linking the actin cytoskeleton with the dystrophin-glycoprotein complex (DGC). In-frame mutations in DMD cause a milder form of X-linked muscular dystroph...
Sex-dependent effect of APOE on Alzheimer's disease and other age-related neurodegenerative disorders [0.03%]
APOE对阿尔茨海默病和其他年龄相关神经退行性障碍的性别依赖效应
Julia Gamache,Young Yun,Ornit Chiba-Falek
Julia Gamache
The importance of apolipoprotein E (APOE) in late-onset Alzheimer's disease (LOAD) has been firmly established, but the mechanisms through which it exerts its pathogenic effects remain elusive. In addition, the sex-dependent effects of APOE...
Anni K Saralahti,Meri I E Uusi-Mäkelä,Mirja T Niskanen et al.
Anni K Saralahti et al.
Tuberculosis is a chronic infection by Mycobacterium tuberculosis that results in over 1.5 million deaths worldwide each year. Currently, there is only one vaccine against tuberculosis, the Bacillus Calmette-Guérin (BCG) vaccine. Despite w...
Cercosporamide inhibits bone morphogenetic protein receptor type I kinase activity in zebrafish [0.03%]
环孢菌素抑制斑马鱼骨形态发生蛋白受体I激酶的活性
Jelmer Hoeksma,Gerard C M van der Zon,Peter Ten Dijke et al.
Jelmer Hoeksma et al.
Zebrafish models are well-established tools for investigating the underlying mechanisms of diseases. Here, we identified cercosporamide, a metabolite from the fungus Ascochyta aquiliqiae, as a potent bone morphogenetic protein receptor (BMP...
Cercosporamide inhibits bone morphogenetic protein receptor type I kinase activity in zebrafish [0.03%]
cercosporamide可通过抑制斑马鱼骨形态生成蛋白受体Ⅰ激酶活性发挥抗关节炎作用
Jelmer Hoeksma,Gerard C M van der Zon,Peter Ten Dijke et al.
Jelmer Hoeksma et al.
Zebrafish models are well-established tools for investigating the underlying mechanisms of diseases. Here, we identified cercosporamide, a metabolite from the fungus Ascochyta aquiliqiae, as a potent bone morphogenetic protein receptor (BMP...
Jeffrey W Santoso,Megan L McCain
Jeffrey W Santoso
Organs-on-chips are broadly defined as microfabricated surfaces or devices designed to engineer cells into microscale tissues with native-like features and then extract physiologically relevant readouts at scale. Because they are generally ...
DMM Outstanding Paper Prize 2019 winner: Alessandro Bailetti [0.03%]
2019年DMM优秀论文奖得主：Alessandro Bailetti
Rachel Hackett
Rachel Hackett
Disease Models & Mechanisms (DMM) is delighted to announce (with apologies for the delay) that the winner of the DMM Prize 2019 is Alessandro Bailetti, for his paper entitled 'Enhancer of Polycomb and the Tip60 complex repress hematological...
Longitudinal neuroanatomical and behavioral analyses show phenotypic drift and variability in the Ts65Dn mouse model of Down syndrome [0.03%]
纵向神经解剖和行为分析显示唐氏综合症小鼠模型Ts65Dn的表型偏移和可变性
Patricia R Shaw,Jenny A Klein,Nadine M Aziz et al.
Patricia R Shaw et al.
Mouse models of Down syndrome (DS) have been invaluable tools for advancing knowledge of the underlying mechanisms of intellectual disability in people with DS. The Ts(1716)65Dn (Ts65Dn) mouse is one of the most commonly used models as it r...
Longitudinal neuroanatomical and behavioral analyses show phenotypic drift and variability in the Ts65Dn mouse model of Down syndrome [0.03%]
纵向神经解剖和行为分析显示唐氏综合征模型Ts65Dn小鼠表现出表型漂移和变异
Patricia R Shaw,Jenny A Klein,Nadine M Aziz et al.
Patricia R Shaw et al.
Mouse models of Down syndrome (DS) have been invaluable tools for advancing knowledge of the underlying mechanisms of intellectual disability in people with DS. The Ts(1716)65Dn (Ts65Dn) mouse is one of the most commonly used models as it r...
Temporal patterning in neural progenitors: from Drosophila development to childhood cancers [0.03%]
神经前体中的时间模式：从果蝇发育到儿童癌症中的应用
Cédric Maurange
Cédric Maurange
The developing central nervous system (CNS) is particularly prone to malignant transformation, but the underlying mechanisms remain unresolved. However, periods of tumor susceptibility appear to correlate with windows of increased prolifera...