UniSePT: an engineered broadly applicable Unique Secretory signal PepTide for high-yield biotherapeutic production in mammalian cell-based expression systems [0.03%]
UniSePT：一种工程化的、广泛适用的用于基于哺乳动物细胞表达系统的生物治疗药物高产产生的独特分泌信号肽
Goutam Ulgekar,Satarupa Dutta,Ealisha Jain et al.
Goutam Ulgekar et al.
Background: The yield of therapeutic proteins in mammalian cell-based production systems is often limited by inefficient secretion and reduced bioactivity caused by incompatible secretory signal peptides (SPs). Therefore,...
Engineering a conditionally active cetuximab prodrug via affibody-based paratope masking [0.03%]
基于Affibody的表位屏蔽条件激活的西妥昔单抗前药的设计与构建
Anna Mestre Borras,Hanna Mehari,Athanasios Bitzios et al.
Anna Mestre Borras et al.
The application of monoclonal antibodies as targeted drugs has revolutionized cancer therapy, yet their efficacy is sometimes limited by toxicities arising from target expression in healthy tissues. Various strategies have emerged to overco...
Clitocine suppresses TNBC progression by boosting CCRL2 to block survival signals and neutrophil-driven inflammation [0.03%]
氯替新通过促进CCRL2阻断生存信号和中性粒细胞驱动的炎症来抑制三阴性乳腺癌进展
Qi Chen,Yanyun Ruan,Shuanshuan Liu et al.
Qi Chen et al.
Background: This study investigates the anti-tumor mechanisms of clitocine, a natural compound, in triple-negative breast cancer (TNBC), with a focus on its role in modulating the immune microenvironment via C-C motif che...
Engineering a PD-L1-sensing synthetic receptor for programmable macrophage response [0.03%]
工程化PD-L1感应合成受体以调控巨噬细胞的程序性免疫反应
Ilaria De Martino,Luigi Russo,Matteo Marchetti et al.
Ilaria De Martino et al.
Cellular decision-making relies on the integration of multiple extracellular cues into coordinated functional responses. Synthetic biology provides tools to rewire this process by engineering receptors that convert defined inputs into progr...
Stem cell research and regenerative medicine: meeting report from the Royan International Stem Cell Congress 2025 [0.03%]
干细胞研究和再生医学：2025年Royan国际干细胞大会报告摘要
Niloofar Bajool,Mehdi Abdolazimi,Mohsen Razzaznian et al.
Niloofar Bajool et al.
The 21st Royan International Stem Cell Congress (3-5 September 2025, Tehran, Iran) convened the global stem cell community to assess the accelerating translation of regenerative medicine from bench to bedside. Over three days, 10 thematic s...
Microengineered bone models: advances and applications of bone-on-a-chip technology [0.03%]
微工程骨模型：骨芯片技术的进展与应用
Hossein Rayat Pisheh,Ahmad Vaez
Hossein Rayat Pisheh
Bone-on-a-Chip (BoC) platforms are emerging microphysiological systems designed to recapitulate the complex cellular, structural, and mechanical microenvironments of human bone. These microfluidic-based models provide enhanced physiological...
Tunable PEGylation platform for efficient siRNA delivery using mesoporous silica nanoparticles [0.03%]
一种用于使用介孔硅纳米颗粒有效递送siRNA的PEG化平台
Taeho Kim,Dongseong Seo,Jonghyun Park et al.
Taeho Kim et al.
Poly(ethylene glycol) (PEG) coatings are widely used to improve nanoparticle stability and biocompatibility, yet conventional PEGylation methods rely on multi-step conjugation that limits reproducibility and restricts control over charge-sh...
Comparative analysis of heterologous lactate dehydrogenase expression in Ogataea polymorpha for enhanced L-Lactic acid production [0.03%]
异源乳酸脱氢酶在 Ogataea polymorpha 中的表达分析及对 D-乳酸高效合成的影响研究
Aksyniia Tsaruk,Justyna Ruchala,Roksolana Vasylyshyn et al.
Aksyniia Tsaruk et al.
Lactic acid (LA) is a key platform chemical with broad industrial applications, including biodegradable plastics and pharmaceuticals. While microbial fermentation enables the sustainable production of optically pure L-lactic acid, challenge...
Fabrication and characterization of novel bigel systems based on natural gums: rheological, textural, and thermal properties [0.03%]
基于天然树胶的大分子凝胶体系的制备及性质研究
Zohreh Baratian Ghorghi,Mohammad Ali Hesarinejad,Ali Faezian et al.
Zohreh Baratian Ghorghi et al.
The fabrication of novel bigel formulations utilizing natural gums presents an attractive and valuable approach for the development of healthy and functional food products. The goal of the current investigation was to establish new bigel sy...
Host cell protein impurities in therapeutic proteins: overview of advances in detection, nonconventional removal technologies and immunogenicity assessment [0.03%]
治疗性蛋白质中的宿主细胞蛋白杂质：检测、非传统去除技术及免疫原性评估的进展概述
Sakhr Alhuthali,Syazana Mohamad Pauzi,Cleo Kontoravdi
Sakhr Alhuthali
Therapeutic proteins, particularly monoclonal antibodies, represent a cutting-edge technology for combating chronic illnesses. These biomolecules are produced in cell-based expression systems that generate thousands of impurities, which mus...