Lisha Mou,Ying Lu,Zijing Wu et al.
Lisha Mou et al.
IntroductionLupus nephritis (LN) is characterized by significant heterogeneity and a complex pathophysiology, which traditional methods struggle to fully resolve. Advanced multi-omics approaches are essential to disentangle its cellular and...
Joseph Mucumbitsi,Jean Claude Hakizimana,Marie Gorette Kampire et al.
Joseph Mucumbitsi et al.
BackgroundTrained immunity, a form of long-term functional reprogramming of innate immune cells through epigenetic and metabolic changes, traditionally confers protection against infections. However, inappropriate activation by endogenous s...
Endothelial progenitor cell numbers vary in newborns and adults; anti-gm-CSFα (CD116) antibody as a novel marker for EPC enumeration [0.03%]
新生儿和成人内皮祖细胞数量差异；抗GM-CSFα（CD116）抗体作为EPC计数的新标志物
Sevil Simsek,Cagatay Karaca,Nezihe Koker et al.
Sevil Simsek et al.
ObjectiveEndothelial progenitor cells (EPCs) originate from hematopoietic stem cells and can be quantified in peripheral blood using flow cytometry. The anti-GM-CSFα antibody (CD116) may serve as a specific marker for EPC enumeration. This...
Immune cells play a mediating role in the relationship between the gut microbiota and dementia: A Mendelian randomization study [0.03%]
免疫细胞在肠道微生物与痴呆关系中起介导作用：一项孟德尔随机化研究
Jianzhun Chen,Liuhui Zhu,Jie Liu et al.
Jianzhun Chen et al.
IntroductionThe gut microbiota modulates dementia pathogenesis through immune interactions. Using Mendelian randomization, we investigate immune mediated mechanisms linking microbial dysbiosis to four dementia subtypes (Alzheimer's disease,...
Periodontitis promotes gingival accumulation of cells with MDSC phenotype [0.03%]
牙周炎促进具有MDSC表型的细胞在龈沟液中的聚集
Fernando García-Arévalo,Gabriela Leija-Montoya,Dulce Martha Fuchen-Ramos et al.
Fernando García-Arévalo et al.
BackgroundPeriodontitis is one of the most common inflammatory diseases in humans, mostly caused by bacterial infection and with diverse populations of immune cells involved. Myeloid-derived suppressor cells (MDSCs), a heterogeneous group o...
High-molecular-weight kininogen is a critical component of host defense against Escherichia coli sepsis [0.03%]
高分子量激肽原是宿主防御大肠杆菌败血症的关键成分
Aizhen Yang,Yue Lu,Xiaofeng Yan et al.
Aizhen Yang et al.
High-molecular-weight kininogen (HK) is known to bind lipopolysaccharides (LPS) with high affinity and serves as a crucial LPS carrier in circulation, supporting endotoxemia. However, its role in host defense against Gram-negative bacterial...
Histopathologic effect and immunomodulatory of Indigofera oblongifolia with silver nanoparticles against splenic injury by Plasmodium chabaudi infection in mice [0.03%]
银纳米颗粒和宽叶木蓝对鼠alaria chabaudi感染所致脾损伤的组织病理学影响及免疫调节作用
Mutee Murshed,Jameel Al-Tamimi,Hind Alzaylaee et al.
Mutee Murshed et al.
Malaria, a globally prevalent disease caused by Plasmodium species, significantly impacts the immune system, particularly affecting splenic function. This study investigates the therapeutic potential of Indigofera oblongifolia leaf extracts...
Primer investigation of RIG-I-like receptors expression in virus infection with the acute character [0.03%]
RLR在急性病毒感染中表达的初步研究
Filip Lewandowski,Rafał Hrynkiewicz,Karolina Wiśniewska et al.
Filip Lewandowski et al.
This study investigates the expression of RIG-I-like receptors (RLRs) - RIG-I, MDA5, and LGP2 - in Lagovirus europaeus/GI.2 infections causing Rabbit Hemorrhagic Disease. Despite over 30 years of study, the acute pathogenesis remains incomp...