The signaling adaptor insulin receptor substrate 2 (IRS2) limits lethal host responses induced by influenza infection [0.03%]
信号转导适配子胰岛素受体底物2通过限制流感病毒感染诱导的致命性宿主反应发挥保护作用
Daniel Prantner,Xiulan Qi,Luz M Villaneuva et al.
Daniel Prantner et al.
Influenza is a highly contagious virus with most individuals showing recovery within a week after symptom onset. However, children, the elderly, and those with chronic health conditions are at high risk of developing serious complications. ...
Innate immune recognition of Bartonella bacilliformis: TLR2/TLR4 expression and cytokine modulation [0.03%]
巴通体感染的固有免疫识别： toll样受体2和4的表达及细胞因子水平的调节
Angie K Castillo,Javier Enciso-Benavides,Ana Mayanga-Herrera et al.
Angie K Castillo et al.
BackgroundConsider this Carrion's disease (CD) is a biphasic illness-comprising acute and chronic phases-endemic to Peru and caused by Bartonella bacilliformis, a bacterium transmitted by sandflies. Despite its clinical relevance, the mecha...
Trained immunity agonists given to neonatal mice fail to protect against leptospiral infection in adulthood and may cause adverse effects [0.03%]
新生小鼠接受的训练免疫激动剂无法在成年后抵御钩端螺旋体感染且可能会产生副作用
Mégane Fernandez,Frédérique Vernel-Pauillac,Tiffany Pezier et al.
Mégane Fernandez et al.
Background and ObjectivesTrained immunity (TI) refers to a non-specific, long-lasting protective immune response that occurs following initial stimulation of the immune system and thought to be largely mediated by functional reprogramming o...
Tn-Glycoconjugates engage MGL2 to potentiate TLR9-mediated dendritic cell maturation and Th1-skewed immune responses [0.03%]
Tn-糖缀合物通过激活DCs中MGL2促进TLR9介导的免疫反应偏向于Th1型响应
Carolina Chiale,Sylvie Bay,Christelle Ganneau et al.
Carolina Chiale et al.
Dendritic cells (DCs) orchestrate antitumor immunity by integrating signals from the tumor microenvironment to prime effective T cell responses. Many tumors display altered glycosylation patterns, including tumor-associated carbohydrate ant...
Advancing lupus nephritis research through multi-omics and predictive modeling [0.03%]
通过多组学和预测建模推进狼疮性肾炎的研究
Lisha Mou,Ying Lu,Zijing Wu et al.
Lisha Mou et al.
IntroductionLupus nephritis (LN) is characterized by significant heterogeneity and a complex pathophysiology, which traditional methods struggle to fully resolve. Advanced multi-omics approaches are essential to disentangle its cellular and...
The role of trained immunity in chronic non-communicable inflammatory diseases [0.03%]
训练免疫在慢性非传染性炎症性疾病中的作用
Joseph Mucumbitsi,Jean Claude Hakizimana,Marie Gorette Kampire et al.
Joseph Mucumbitsi et al.
BackgroundTrained immunity, a form of long-term functional reprogramming of innate immune cells through epigenetic and metabolic changes, traditionally confers protection against infections. However, inappropriate activation by endogenous s...
Endothelial progenitor cell numbers vary in newborns and adults; anti-gm-CSFα (CD116) antibody as a novel marker for EPC enumeration [0.03%]
新生儿和成人内皮祖细胞数量差异；抗GM-CSFα（CD116）抗体作为EPC计数的新标志物
Sevil Simsek,Cagatay Karaca,Nezihe Koker et al.
Sevil Simsek et al.
ObjectiveEndothelial progenitor cells (EPCs) originate from hematopoietic stem cells and can be quantified in peripheral blood using flow cytometry. The anti-GM-CSFα antibody (CD116) may serve as a specific marker for EPC enumeration. This...
Immune cells play a mediating role in the relationship between the gut microbiota and dementia: A Mendelian randomization study [0.03%]
免疫细胞在肠道微生物与痴呆关系中起介导作用：一项孟德尔随机化研究
Jianzhun Chen,Liuhui Zhu,Jie Liu et al.
Jianzhun Chen et al.
IntroductionThe gut microbiota modulates dementia pathogenesis through immune interactions. Using Mendelian randomization, we investigate immune mediated mechanisms linking microbial dysbiosis to four dementia subtypes (Alzheimer's disease,...