High-molecular-weight kininogen is a critical component of host defense against Escherichia coli sepsis [0.03%]
高分子量激肽原是宿主防御大肠杆菌败血症的关键成分
Aizhen Yang,Yue Lu,Xiaofeng Yan et al.
Aizhen Yang et al.
High-molecular-weight kininogen (HK) is known to bind lipopolysaccharides (LPS) with high affinity and serves as a crucial LPS carrier in circulation, supporting endotoxemia. However, its role in host defense against Gram-negative bacterial...
Histopathologic effect and immunomodulatory of Indigofera oblongifolia with silver nanoparticles against splenic injury by Plasmodium chabaudi infection in mice [0.03%]
银纳米颗粒和宽叶木蓝对鼠alaria chabaudi感染所致脾损伤的组织病理学影响及免疫调节作用
Mutee Murshed,Jameel Al-Tamimi,Hind Alzaylaee et al.
Mutee Murshed et al.
Malaria, a globally prevalent disease caused by Plasmodium species, significantly impacts the immune system, particularly affecting splenic function. This study investigates the therapeutic potential of Indigofera oblongifolia leaf extracts...
Primer investigation of RIG-I-like receptors expression in virus infection with the acute character [0.03%]
RLR在急性病毒感染中表达的初步研究
Filip Lewandowski,Rafał Hrynkiewicz,Karolina Wiśniewska et al.
Filip Lewandowski et al.
This study investigates the expression of RIG-I-like receptors (RLRs) - RIG-I, MDA5, and LGP2 - in Lagovirus europaeus/GI.2 infections causing Rabbit Hemorrhagic Disease. Despite over 30 years of study, the acute pathogenesis remains incomp...
Bridging two worlds: Host Microbiota crosstalk in health and dysregulation [0.03%]
沟通两个世界：宿主微生态在健康与失调中的相互作用
Mahjabin Sanam,Chowdhury Fatema Tuz Zohra Hossain,Tahmida Binte Hyder et al.
Mahjabin Sanam et al.
The gut microbiota plays a crucial role in various physiological functions, such as the production of microbial compounds and maintaining homeostatic equilibrium by complex host-microbial interactions. However, any shift in the constitution...
Acute-phase response- and inflammation-, but not extracellular matrix-related proteins in the amniotic fluid are associated with spontaneous preterm delivery in asymptomatic women with midtrimester short cervix [0.03%]
急性期反应和炎症而非细胞外基质相关蛋白与无症状中期宫颈短的孕妇自发性早产的关系研究
Kyo Hoon Park,Bo Young Choi,Kyong-No Lee et al.
Kyo Hoon Park et al.
Background: To determine whether (i) altered levels of acute-phase response (APR)-, inflammation-, and extracellular matrix (ECM)-related proteins in the amniotic fluid (AF) were associated with spontaneous preterm delivery (SPTD) in asympt...
Bronchial pyroptosis promotes Th17 inflammation in steroid-insensitive asthma mouse [0.03%]
气道焦亡促进糖皮质激素抵抗性哮喘小鼠Th17炎症反应
Yun Lin,Jianhua Yin,Xia Yang et al.
Yun Lin et al.
Bronchial cell pyroptosis and IL-17 respectively contribute- to the pathogenesis of steroid-insensitive asthma. In this study, we aim to explore the relationship between bronchial cell pyroptosis and Th17 in airway inflammation of steroid-i...
Pre-stimulation of precision-cut bovine udder slices with zymosan before LPS exposure indicates aspects of trained immunity especially in the absence of FCS [0.03%]
zymosan预激活的牛乳房精密切片在没有FCS的情况下接触LPS后，表明了训练免疫的某些方面
Viviane Filor,Joanna Myslinska,Amitis Saliani et al.
Viviane Filor et al.
Mastitis in cattle poses a significant health challenge and results in substantial economic losses for the dairy industry. This study aimed to extend the existing precision-cut bovine udder slices (PCBUS) model as an in vitro model to explo...
Working in negative space: Type I interferon mediated immuno-modulation through transcriptional suppression in disease and homeostasis [0.03%]
工作在负空间：I型干扰素介导的疾病和稳态下的转录抑制性免疫调节
Ella L Brunsting,Darren J Perkins
Ella L Brunsting
The type I interferon family of cytokines are rapidly produced following innate pattern recognition receptor engagement and establish a critical early state of host defense. Type I interferons act in antiviral immunity as transcriptional ac...
Jingyi Wang,Teng Deng,Ruisi Chen et al.
Jingyi Wang et al.
Neutrophils play a pivotal role in the host immune system, serving as the frontline defense against microbial infections. They eradicate pathogens through diverse mechanisms, encompassing degranulation, phagocytosis, and the release of reac...