A disease model predicting placebo response and remission status of patients with ulcerative colitis using modified Mayo score [0.03%]
基于改良梅奥评分的溃疡性结肠炎患者假手术效应和缓解状态的疾病模型预测
Anita Moein,Jurgen Langenhorst,Elodie L Plan et al.
Anita Moein et al.
The Mayo Clinical Score is used in clinical trials to describe the clinical status of patients with ulcerative colitis (UC). It comprises four subscores: rectal bleeding (RB), stool frequency (SF), physician's global assessment, and endosco...
Model-informed precision dosing of vancomycin for rapid achievement of target area under the concentration-time curve: A simulation study [0.03%]
基于模型的精准万古霉素给药以快速达到目标下浓度曲线下面积：一项模拟研究
Kazutaka Oda,Tomoyuki Yamada,Kazuaki Matsumoto et al.
Kazutaka Oda et al.
In this study, we aimed to evaluate limited sampling strategies for achieving the therapeutic ranges of the area under the concentration-time curve (AUC) of vancomycin on the first and second day (AUC0-24 , AUC24-48 , respectively) of thera...
Prevalence and prescribing patterns of oral corticosteroids in the United States, Taiwan, and Denmark, 2009-2018 [0.03%]
2009～2018年美国、台湾和丹麦口服糖皮质激素的流行病学与处方特征
Beth I Wallace,Hui-Ju Tsai,Paul Lin et al.
Beth I Wallace et al.
Oral corticosteroids (OCS) are commonly prescribed for acute, self-limited conditions, despite studies demonstrating toxicity. Studies evaluating longitudinal OCS prescribing in the general population are scarce and do not compare use acros...
Application of a physiologically based pharmacokinetic model to predict isoniazid disposition during pregnancy [0.03%]
生理药动学模型在预测孕妇异烟肼代谢中的应用研究
Ogochukwu U Amaeze,Nina Isoherranen
Ogochukwu U Amaeze
Pregnancy can increase the risk of latent tuberculosis infection (LTBI) progression to tuberculosis (TB) disease. Isoniazid (INH) is the preferred preventative treatment for LTBI in pregnancy. INH is mainly cleared by N-acetyltransferase 2 ...
Association between serum albumin to serum creatinine ratio and mortality risk in patients with heart failure [0.03%]
血清白蛋白与肌酐比值与心力衰竭患者死亡风险之间的关系
Shiyang Li,Xiaoshuang Xie,Xiaobin Zeng et al.
Shiyang Li et al.
The aim of this study was to investigate the association between serum albumin to serum creatinine ratio (sACR) and the prognosis of heart failure (HF). In this single-center prospective cohort study, a total of 2625 patients with HF were e...
Effect of itraconazole and fluconazole on the pharmacokinetics of valemetostat: An open-label, phase I study in healthy subjects [0.03%]
伊曲康唑和氟康唑对瓦利莫妥珠单抗药代动力学的影响：健康受试者中的开放标签1期研究
Masaya Tachibana,Shunji Matsuki,Yutaro Maekawa et al.
Masaya Tachibana et al.
Valemetostat tosylate (valemetostat) is an oral, potent, dual inhibitor of enhancer of zeste homolog (EZH) 2 and EZH1 under investigation for the treatment of cancer, including non-Hodgkin's lymphomas and solid tumors. Itraconazole and fluc...
Various effects of repeated rifampin dosing on coproporphyrin levels in humans [0.03%]
反复给予利福平对人血粪卟啉的影响
Jonny Kinzi,Markus Grube,Karin Brecht et al.
Jonny Kinzi et al.
In recent years, the identification of endogenous substrates as biomarkers became an uprising topic. Particularly coproporphyrins (CPs), byproducts of heme biosynthesis, are intensely investigated as biomarkers for predicting interactions w...
A pilot study to identify pharmacogenomic and clinical risk factors associated with opioid related falls and adverse effects in older adults [0.03%]
一项试点研究：识别与老年人涉阿片类药物跌倒和不良反应相关的药理基因组学和临床风险因素
Sophia Sheikh,Rosemarie Fernandez,Carmen Smotherman et al.
Sophia Sheikh et al.
Given the high prevalence of pain in older adults and current trends in opioid prescribing, inclusion of genetic information in risk prediction tools may improve opioid risk assessment. Our objectives were to (1) determine the feasibility o...
Observational Study
Clinical and translational science. 2023 Nov;16(11):2331-2344. DOI:10.1111/cts.13634 2023
Reconsideration of the current models of estimated kidney function-based drug dose adjustment in older adults: The role of biological age [0.03%]
基于肾功能估算的药物剂量调整的再思考：生物学年龄的作用
Radin Alikhani,Manjunath P Pai
Radin Alikhani
Human lifespan has increased from a median of 46.5 years in 1950 to 71.7 years in 2022. As people age, one of the inevitable consequences is a decline in kidney function and glomerular filtration rate (GFR) which can have direct or indirect...
Opportunities and challenges of 5G network technology toward precision medicine [0.03%]
面向精准医疗的5G网络技术机遇与挑战
Chia Chao Kang,Tze Yan Lee,Wai Feng Lim et al.
Chia Chao Kang et al.
Moving away from traditional "one-size-fits-all" treatment to precision-based medicine has tremendously improved disease prognosis, accuracy of diagnosis, disease progression prediction, and targeted-treatment. The current cutting-edge of 5...